Comprehensive study to elucidate molecular mechanisms behind intrahepatic cholestasis
| Project/Area Number |
22590746
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胆汁酸トランスポーター / 胆汁うっ滞 / 胆汁分泌 / ウルソデオキシコール酸 / 胆汁酸 / トランスポーター / 膜タンパク |
|---|
| Research Abstract |
Intrahepatic cholestasis is a difficult-to-treat disease. Although ursodeoxycholic acid has choleretic effect and is widely used to treat cholestasis, molecular mechanisms behind this effect remain unknown. In this study we demonstrated that ursodeoxycholic acid induces choleresis by stabilizing bile salt export pump in the apical membrane.
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Report
(4 results)
Research Products
(33 results)
