| Project/Area Number |
22590747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Akira 東京医科大学, 医学部, 准教授 (10468639)
MATSUZAKI Yasushi 東京医科大学, 医学部, 教授 (50209532)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZAKI Teruo 東京医科大学, 医学部, 助教 (60532687)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | C 型肝炎ウイルス / コレステロール代謝 / 酸化ステロール / C型肝炎ウイルス / コレステロール / 胆汁酸 / 7dehydroxycholesterol / 慢性肝疾患 / 脂質代謝 |
|---|
| Research Abstract |
To identify key sites of HCV interference in the cholesterol metabolic pathways including absorption, biosynthesis, and catabolism, serum biomarkers of patients with HCV infection were determined. The results demonstrate that down-regulated post-squalene cholesterol biosynthesis and increased oxysterol production are characteristic features of patients with HCV infection.
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