Role of bone marrow-derived cells during pancreatic tumorigenesis

• Project/Area Number: 22590754
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: 医療法人 徳洲会 札幌東徳州会病院付属臨床研究センター (2012); Asahikawa Medical College (2010-2011)
• Principal Investigator: MIZUKAMI Yusuke 医療法人 徳洲会 札幌東徳州会病院付属臨床研究センター, 再生医療研究部, 部門長 (30400089)
• Co-Investigator(Renkei-kenkyūsha): II Masaaki 大阪医科大学, 大阪医科大学, 講師 (10442922)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵癌 / 間質 / 骨髄 / 遺伝子改変マウス / 膵臓 / 遺伝子改変マウスモデル

Research Abstract

Tumor-derived factors affect the stroma of cancer tissue. One of the key components of this response is the mobilization of the progenitors from the bone marrow (BM), which contribute toward the development of desmoplastic stroma. These BM-derived cells are involved in normal physiological processes such as tissue repair and wound healing; however, in cancer bearing hosts, these cells actively contribute toward the chaotic microenvironment. Using genetically engineered mice models for pancreatic cancer, we found that BM-progenitors are passively activated by even early stage tumors. We have identified the signaling pathways by which BM-derived cells are recruited and activated to establish malignant stroma in later stages of tumor development.

Research Products

• [Journal Article] Autofluorescence imaging and the quantitative intensity of fluorescence for evaluating the dysplastic grade of colonic neoplasms (2012)
  • Author(s): Moriichi K, Fujiya M, Sato R, Watari J, et al
  • Journal Title: Int J Colorectal Dis Volume: 27 Issue: 3 Pages: 325-330
  • DOI: 10.1007/s00384-011-1311-8
  • Peer Reviewed
• [Journal Article] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection (2012)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
  • Journal Title: Int J Colorectal Diseases Volume: (in press) Issue: 8 Pages: 1039-46
  • DOI: 10.1007/s00384-012-1416-8
  • Peer Reviewed
• [Journal Article] Xavier RJ, ChungDC. Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines (2012)
  • Author(s): Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 302 (10) Issue: 10 Pages: G1223-G1230
  • DOI: 10.1152/ajpgi.00047.2011
  • Peer Reviewed
• [Journal Article] Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids (2012)
  • Author(s): Motomura W, Yoshizaki T, Takahashi N, Kumei S, Mizukami Y, Jang SJ, Kohgo Y
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 3 Pages: 163-169
  • DOI: 10.3164/jcbn.12-06
  • NAID: 130004466691
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Bone marrow-derived proangiogenic cells in pancreatic cancer (2012)
  • Author(s): Mizukami Y
  • Journal Title: J Gastroenterol Hepatol Volume: Suppl 2 Issue: s2 Pages: 23-6
  • DOI: 10.1111/j.1440-1746.2011.07012.x
  • Peer Reviewed
• [Journal Article] Abnormal tumor vasculatures and bone marrow-derived pro- angiogenic cells in cancer (2012)
  • Author(s): Mizukami Y, Sasajima J, Ashida T, Kohgo Y.
  • Journal Title: International Journal of Hematology Volume: 95 Issue: 2 Pages: 125-130
  • DOI: 10.1007/s12185-012-1017-x
  • NAID: 10030267084
  • Peer Reviewed
• [Journal Article] Autofluorescence imaging and the quantitative intensity of fluorescence for evaluating the dysplastic grade of colonic neoplasms (2012)
  • Author(s): Moriichi K, Fujiya M, Sato R, Nata T, Nomura Y, Ueno N, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Mizukami Y, Watari J, Saitoh Y, Kohgo Y
  • Journal Title: International Journal of Colorectal Disease Volume: 27 Pages: 325-30
  • Peer Reviewed
• [Journal Article] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection (2012)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
  • Journal Title: International Journal of Colorectal Disease Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] ONCOGENIC KRAS REGULATES BMP4 EXPRESSION IN COLON CANCER CELL LINES (2012)
  • Author(s): Duerr EM, Mizukami Y Moriichi K, Gala M, Jo WS, Kikuchi H,Xavier RJ, ChungDC
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: (Epub aheadof print)
  • Peer Reviewed
• [Journal Article] Abnormal tumor vasculatures and bone marrow-derived pro-angiogenic cells in cancer (2012)
  • Author(s): Mizukami Y Sasajima J, Ashida T, Kohgo Y
  • Journal Title: International Journal of Hematology Volume: 95 Pages: 125-30
  • NAID: 10030267084
  • Peer Reviewed
• [Journal Article] 『消化器癌治療における新しい分子標的』バイパスシグナルの多様性からみて分子標的治療をどのように進めるか (2012)
  • Author(s): 水上裕輔、河本徹、高後裕
  • Journal Title: 分子消化器病 Volume: 9 Pages: 12-18
• [Journal Article] Localization of the most severely dysplastic/ invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm (IPMN) of the pancreas (2011)
  • Author(s): Mizukami Y, Tokusashi Y, Koizumi K, Ishizaki A, Imai K, Yoshikawa D, Kino S, Sasajima J, Tanno S, Matsumoto K, Miyokawa N, Kono T, Kohgo Y, Furukawa H.
  • Journal Title: Pancreas Volume: 40 Issue: 4 Pages: 588-594
  • DOI: 10.1097/mpa.0b013e31820d1a03
  • Peer Reviewed
• [Journal Article] Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function. (2011)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y.
  • Journal Title: Inflamm Bowel Dis Volume: 17 Issue: 11 Pages: 2235-2250
  • DOI: 10.1002/ibd.21597
  • Peer Reviewed
• [Journal Article] Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13). (2011)
  • Author(s): Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, Ito S, Okamura N, Ichiki K, Tanaka H, Shindo M, Hirai K, Mizukami Y, Otake T, Fujiya M, Sasaki K, Kohgo Y.
  • Journal Title: Int J Hematol Volume: 93 Issue: 3 Pages: 311-318
  • DOI: 10.1007/s12185-011-0786-y
  • NAID: 10029533807
  • Peer Reviewed
• [Journal Article] The diagnostic accuracy of high-resolution endoscopy, autofluorescence imaging and narrow-band imaging for differentially diagnosing colon adenoma (2011)
  • Author(s): Sato R, Fujiya M, Watari J, et al
  • Journal Title: Endoscopy Volume: 43 Issue: 10 Pages: 862-868
  • DOI: 10.1055/s-0030-1256510
  • NAID: 10031131117
  • Peer Reviewed
• [Journal Article] Localization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm (IPMN) of the pancreas (2011)
  • Author(s): Karasaki H, Mizukami Y, Tokusashi Y Koizumi K, Ishizaki A, Imai K, Yoshikawa D, Kino S, Sasajima J, Tanno S, Matsumoto K, Miyokawa N, Kono T, Kohgo Y, Furukawa H
  • Journal Title: Pancreas Volume: 40 Pages: 588-94
  • Peer Reviewed
• [Journal Article] Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function (2011)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Moriichi K, Tanabe H, Mizukami y Kobayashi N, Ito K,Kohgo Y
  • Journal Title: Inflamm Bowel Dis Volume: 17 Pages: 2235-50
  • Peer Reviewed
• [Journal Article] Loss of ABCB7 gene : pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13) (2011)
  • Author(s): Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, Ito S, Okamura N, Ichiki K, Tanaka H, Shindo M, Hirai K, Mizukami Y, Otake T, Fujiya M, Sasaki K, Kohgo Y
  • Journal Title: Int J Hematol Volume: 93 Pages: 311-8
  • NAID: 10029533807
  • Peer Reviewed
• [Journal Article] The diagnostic accuracy of high-resolution endoscopy, autofluorescence imaging and narrow-band imaging for differentially diagnosing colon adenoma (2011)
  • Author(s): Sato R, Fujiya M, Watari J, Ueno N, Moriichi K, Kashima S,Maeda S, Ando K, Kawabata H,Suglyama R, Nomura Y, Nata T, Itabashi K, Inaba Y, Okamoto K, Mizukami Y, Saitoh Y, Kohgo Y
  • Journal Title: Endoscopy Volume: 43 Pages: 862-8
  • NAID: 10031131117
  • Peer Reviewed
• [Journal Article] 消化器癌のCancer Stem Cell, Cancer Initiating Cell7)膵がん微小環境からがん幹細胞をみる (2011)
  • Author(s): 水上裕輔、笹島順平、高後裕
  • Journal Title: 分子消化器病 Volume: 8 Pages: 47-53
• [Journal Article] 早期膵癌の病態解明 早期膵癌解明に向けた遺伝子解析 4.膵癌の間質形成制御に関連する遺伝子解析の動向 (2011)
  • Author(s): 水上裕輔、杉山祥晃、高後裕
  • Journal Title: 肝胆膵 Volume: 62 Pages: 505-511
• [Journal Article] 新しい消化器疾患動物モデル(第2回)新たな膵発癌モデル (2011)
  • Author(s): 水上裕輔、河本徹、高後裕
  • Journal Title: 分子消化器病 Pages: 167-171
• [Journal Article] トップランナーに聞く-最先端の医療に挑む若手研究者への直撃インタビュー(1)難治性がんの撲滅を目指して (2011)
  • Author(s): 水上裕輔
  • Journal Title: 最新医学 Volume: 66 Pages: 120-122
  • NAID: 40017657770
• [Journal Article] Localization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm(IPMN)of the pancreas. (2011)
  • Author(s): Karasaki H, Mizukami Y, Tbkusashi Y, et al.
  • Journal Title: Pancreas Volume: Epub ahead of print(in press)
  • Peer Reviewed
• [Journal Article] Loss of ABCB7 gene : pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric(X)(q13). (2011)
  • Author(s): Sato K, Torimoto Y, Hosoki T, et al.
  • Journal Title: Int J Hematol Volume: 93 Pages: 311-318
  • Peer Reviewed
• [Journal Article] An unusual elevated lesion of the oesophagus. (2011)
  • Author(s): Sawada K, Ikuta K, Itabashi K, et al.
  • Journal Title: Gut Volume: 60 Pages: 441-441
  • Peer Reviewed
• [Journal Article] Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice. (2011)
  • Author(s): Inaba Y, Ashida T, Ito T, et al.
  • Journal Title: Inflammatory Bowel Disease Volume: 16 Pages: 1488-1495
  • Peer Reviewed
• [Journal Article] Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function. (2011)
  • Author(s): Ueno N, Fujiya M, Segawa S, et al
  • Journal Title: Imflammatory Bowel Disease Volume: Epub ahead of print(in press)
  • Peer Reviewed
• [Journal Article] Incidence of synchronous and metachronous pancreatic carcinoma in 168 patients with branch duct intraductal papillary mucinous neoplasm. (2011)
  • Author(s): Tanno S, Nakano Y, Sugiyama Y, et al.
  • Journal Title: Pancreatology Volume: 10 Pages: 173-178
  • Peer Reviewed
• [Journal Article] Pancreatic ductal adenocarcinomas in patients with branch duct intraductal papillary-mucinous neoplasms. (2011)
  • Author(s): Tanno S, Nakano Y, Koizumi K, et al.
  • Journal Title: pancreas Volume: 39 Pages: 36-40
  • Peer Reviewed
• [Journal Article] Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. (2010)
  • Author(s): Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y.
  • Journal Title: PLoS One Volume: 5 Issue: 1 Pages: e8824-e8824
  • DOI: 10.1371/journal.pone.0008824
  • NAID: 120004138817
  • Peer Reviewed
• [Journal Article] Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer. (2010)
  • Author(s): Sakamoto J, Fujiya M, Okamoto K, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Watari J, Ashida T, Kohgo Y.
  • Journal Title: Cancer Epidemiology Volume: 34 Issue: 2 Pages: 194-199
  • DOI: 10.1016/j.canep.2010.01.004
  • Peer Reviewed
• [Journal Article] Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice. (2010)
  • Author(s): Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
  • Journal Title: Inflammatory Bowel Disease Volume: 16 Issue: 9 Pages: 1488-1495
  • DOI: 10.1002/ibd.21253
  • Peer Reviewed
• [Journal Article] Incidence of synchronous and metachronous pancreatic carcinoma in 168 patients with branch duct intraductal papillary mucinous neoplasm. (2010)
  • Author(s): Tanno S, Nakano Y, Sugiyama Y, Nakamura K, Sasajima J, Koizumi K, Yamazaki M, Nishikawa T, Mizukami Y, Yanagawa N, Fujii T, Obara T, Okumura T, Kohgo Y.
  • Journal Title: Pancreatology Volume: 10 Issue: 2-3 Pages: 173-178
  • DOI: 10.1159/000231982
  • Peer Reviewed
• [Journal Article] Pancreatic ductal adenocarcinomas in patients with branch duct intraductal papillary-mucinous neoplasms (2010)
  • Author(s): Tanno S, Nakano Y, Koizumi K, Yamazaki M, Nakamura K, Sasajima J, Nishikawa T, Mizukami Y, Yanagawa N, Fujii T, Obara T, Okumura T, Kohgo Y.
  • Journal Title: Pancreas Volume: 39 Issue: 1 Pages: 36-40
  • DOI: 10.1097/mpa.0b013e3181b91cd0
  • Peer Reviewed
• [Journal Article] Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors (2010)
  • Author(s): Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe JI, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y.
  • Journal Title: Cancer Research Volume: 70 Issue: 15 Pages: 6283-6292
  • DOI: 10.1158/0008-5472.can-10-0412
  • Peer Reviewed
• [Journal Article] Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors. (2010)
  • Author(s): Sasajima J, Mizukami Y, Sugiyama Y, et al.
  • Journal Title: Cancer Research Volume: 70 Pages: 6283-6292
  • Peer Reviewed
• [Journal Article] Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. (2010)
  • Author(s): Nakamura K, Sasajima J, Mizukami Y, et al.
  • Journal Title: PLoS One Volume: 5
  • NAID: 120004138817
  • Peer Reviewed
• [Presentation] 膵発癌の後期段階でのHedgehog過剰発現におけるHedgehog interacting protein (Hip)の役割.WS-6エピジェネテイクスの臨床応用 (2011)
  • Author(s): 杉山祥晃、笹島順平、河本徹、小泉一也、水上裕輔、高後裕
  • Organizer: 日本消化器癌発生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2011-11-25
• [Presentation] Bone marrow-derived proangiogenic cells in pancreatic cancer. Session 1 : Stem cells in ALD, liver and pancreatic cancer (2011)
  • Author(s): Mizukami Y
  • Organizer: The 6th International Symposium on ALPD and Cirrhosis
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] Angiogenesis & Stemness in Pancreatic Cancer: Role of Bone Marrow-derived Cells. (2011)
  • Author(s): 水上裕輔
  • Organizer: 第63回日本細胞生物学会大会 MS5 血管の多様性～組織発生から疾患におけるダイナミクス
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-29
• [Presentation] Angiogenesis & Stemness in Pancreatic Cancer : Role of Bone Marrow-derived Cells.MS5血管の多様性～組織発生から疾患におけるダイナミクス (2011)
  • Author(s): 水上裕輔
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-06-29
• [Presentation] 長期経過観察中に多彩な画像変化を呈し診断に苦慮した脾上皮嚢胞の1例 (2011)
  • Author(s): 河本徹、小泉一也、堂腰達矢、杉山祥晃、笹島順平、水上裕輔、唐崎秀則、鈴木康秋、高後裕
  • Organizer: 第108回消化器病学会北海道地方会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-04
• [Presentation] 自己免疫性膵炎における慢性炎症の持続と治療法の問題点 (2011)
  • Author(s): 小泉一也、丹野誠志、西川智哉、河本徹、杉山祥晃、笹島順平、藤永明裕、後藤拓磨、柳川伸幸、中村和正、千葉篤、中野靖弘、藤井常志、水上裕輔、高後裕
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] The paracrine effect of hedgehog on bone marrow-derived stromal cells occurs at later stages of pancreatic tumorigenesis (2011)
  • Author(s): Sugiyama Y, Mizukami Y, Kawamoto T, Sasajima J, Koizumi K, Nomura Y, Moriichi K, Fujiya M, Bardeesy N, Chung DC, Kohgo Y.
  • Organizer: Digestive Disease Week 2010, Topic Forum; Biology of the Pancreas
  • Place of Presentation: Chicago, IL
  • Year and Date: 2011-05-11
• [Presentation] The paracrine effect of hedgehog on bone marrow-derived stromal cells occurs at later stages of pancreatic tumorigenesis. American Gastroent erology Association : Topic Forum. Biology of the pancreas (2011)
  • Author(s): Sugiyama Y, Mizukami Y, Kawamoto,T, Sasajima J, Koizumi K,Nomura Y, Moriichi K, Fujiya M, Bardeesy N, Chung DC, Kohgo Y
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: 米国・シカゴ
  • Year and Date: 2011-05-10
• [Presentation] 腫瘍血管「修復」による低酸素の解除 (2011)
  • Author(s): 水上裕輔
  • Organizer: 第8回がんとハイポキシア研究会 シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2011-01-29
• [Presentation] 血管「修復」による腫瘍低酸素の解除 (2011)
  • Author(s): 水上裕輔
  • Organizer: がんとハイポキシア研究会シンポジウム
  • Place of Presentation: 札幌 招待講演
  • Year and Date: 2011-01-29
• [Presentation] Transplantion of pro-angiogenic monocytes to pancreatic cancer-bearing mice attenuates resistance to chemotherapy/radiotherapy (2011)
  • Author(s): Mizukami Y, Kawamoto T, Sugiyama Y, Sasajima J, Koizumi, K, Moriichi K, Fujiya M, Bardeesy N, Chung DC, Kohgo K.
  • Organizer: 2011 Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco, CA.
• [Presentation] Bone marrow-derived proangiogenic cells in pancreatic cancer. The 6th International Symposium on ALPD and Cirrhosis (2011)
  • Author(s): Mizukami Y.
  • Organizer: Session1:Stem cells in ALD, liver and pancreatic cancer.
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Transplantioh of pro-angiogenic monocytes to pancreatic cancer-bearing mice attenuates resistance to chemotherapy/radiotherapy. (2011)
  • Author(s): Mizukami Y, Kawamoto T, Sugiyama Y, et al.
  • Organizer: 2011 Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco, CA
• [Presentation] ANGIOGENESIS & STEMNESS IN PANCREATIC CANCER: THERAPEUTIC IMPLICATIONS (2010)
  • Author(s): Mizukami Y.
  • Organizer: The 1st JSGE International Topic Conference, Plenary Session III, Pancreas (1)
  • Place of Presentation: Kamakura
  • Year and Date: 2010-10-25
• [Presentation] ANGIOGENESIS & STEMNESS IN PANCREATIC CANCER THERAPEUTIC IMPLICATIONS. (2010)
  • Author(s): Mizukami Y
  • Organizer: The 1st JSGE International Topic Conference
  • Place of Presentation: Kamakura, Japan 招待講演
  • Year and Date: 2010-10-25
• [Presentation] 腫瘍血管リモデリングは腫瘍低酸素を解除し、がん幹細胞様形質を軽減する (2010)
  • Author(s): 水上裕輔、笹島順平、高後 裕
  • Organizer: JDDW2010 S10(日本消化器病学会)消化器癌における幹細胞研究の現状
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 腫瘍血管リモデリングは腫瘍低酸素を解除し、がん幹細胞様形質を軽減する (2010)
  • Author(s): 水上裕輔、笹島順平、高後裕
  • Organizer: JDDW2010日本消化器病学会シンボジウム1O
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 自己免疫性膵炎の長期経過とステロイド治療による影響 (2010)
  • Author(s): 小泉一也、水上裕輔、高後裕
  • Organizer: JDDW2010日本消化器病学会パネルディスカッション5
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] がんと骨髄～腫瘍血管新生をターゲットとしたトランスレーショナルリサーチ (2010)
  • Author(s): 水上裕輔
  • Organizer: 北海道癌談話会秋期シンポジウム
  • Place of Presentation: 札幌 招待講演
  • Year and Date: 2010-10-09
• [Presentation] ステロイド反応性からみた自己免疫性膵炎の診断 (2010)
  • Author(s): 小泉一也、河本徹、杉山祥晃, 他
  • Organizer: 北海道消化器病学会支部例会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-11
• [Presentation] Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduced hypoxia in tumors (2010)
  • Author(s): Mizukami Y, Sasajima J, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi, K, Sato K, Suzuki Y, Fujiya M, Sasaki K, Torimoto Y, Karasaki H, Kono T, Kohgo K.
  • Organizer: 9th International Conference of The Asian Clinical Oncology Society (ACOS), Mini Symposium 8; Recent advances in pancreatic cancer
  • Place of Presentation: Gifu
  • Year and Date: 2010-08-26
• [Presentation] Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduced hypoxia in tumors. (2010)
  • Author(s): Mizukami Y, Sasajima J, Sugiyama Y, et al.
  • Organizer: 9th International Conference of The Asian Clinical Oncology Society(ACOS), Mini Symposium 8
  • Place of Presentation: Gifu, Japan
  • Year and Date: 2010-08-26
• [Presentation] Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduced hypoxia in tumors (2010)
  • Author(s): Mizukami Y.
  • Organizer: 16th International Vascular Biology Meeting. Plenary session; Status quo in Tumor Angiogenesis
  • Place of Presentation: Los Angeles, CA
  • Year and Date: 2010-06-24
• [Presentation] Transplanting normal vascular proangiogenic cells to trmor-bearing mice triggers vascular remodeling and reduced hypoxia in tumors. (2010)
  • Author(s): Mizukami Y
  • Organizer: 16th International Vascular Biology Meeting Plenary session ; Status quo in Tumor Angiogenesis
  • Place of Presentation: Los Angeles, CA
  • Year and Date: 2010-06-24
• [Presentation] 膵癌間質におけるHedgehogのparacrine経路は自然発症膵発癌の後期段階で活性化する (2010)
  • Author(s): 水上裕輔、笹島順平、杉山祥晃、河本 徹、伊井正明、高後 裕
  • Organizer: 第19回日本がん転移学会学術集会
  • Place of Presentation: 金沢(ポスター発表)
  • Year and Date: 2010-06-19
• [Presentation] 分枝型IPMNにおける内視鏡検査の意義と壁在結節描出能の検討 (2010)
  • Author(s): 小泉一也、丹野誠志、芹川真哉, 他
  • Organizer: 日本内視鏡学会北海道支部例会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-05
• [Presentation] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. (2010)
  • Author(s): Okamoto K, Fujiya M, Nata T, et a1.
  • Organizer: DDW2010, AGA Poster Session
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-05-05
• [Presentation] The Tumor Vasculature is a Paracrine Target of Hedgehog in Pancreatic Cancer (2010)
  • Author(s): Sugiyama Y, Mizukami Y, Sasajima J, Kawamto T, Koizumi K, Fujiya M, Tanno S, Karasaki H, Kono T, Bardessy N, Chung DC, and Kohgo Y.
  • Organizer: NOTCH AND SHH SIGNALING IN GASTROINTESTINAL HOMEOSTASIS
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-05-04
• [Presentation] Heat-Killed Body of Lactobacillus brevis Sbc8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis (2010)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y.
  • Organizer: AGA Poster Session
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-05-04
• [Presentation] The tumor vasculature is a paracrine target of Hedgehog in pancreatic cancer. (2010)
  • Author(s): Sugiyama Y, Mizukami Y, Sasajima J, et al.
  • Organizer: DDW 2010, AGA Plenary session
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-04
• [Presentation] Heat-Killed Body of Lactobacillus brevis Sbc8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis. (2010)
  • Author(s): Ueno N,Fujiya M, Segawa S, et al.
  • Organizer: DDW2010, AGA Poster Session
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-05-04
• [Presentation] The Tumor Vasculature is a Paacrine Target of Hedgehog in Pancreatic Cancer. (2010)
  • Author(s): Sugiyama Y, Mizukami Y, Sasajrima J, et al.
  • Organizer: DDW2010, AGA Distinguished Abstract Plenary, NOTCH AND SHH SIGNALING IN GASTROINTESTINAL HOMEOSTASIS
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-05-04
• [Presentation] 自己免疫性膵炎における膵外病変からみた疾患活動性に関する検討 (2010)
  • Author(s): 小泉一也、丹野誠志、藤井常志, 他
  • Organizer: 日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] Activation of Hedgehog pathway in tumor vasculature is a late event of pancreatic tumorigenesis (2010)
  • Author(s): Sasajima J, Mizukami Y, Nakamura K, Sugiyama Y, Kawamoto T, Koizumi K, Sato K, Tanno S, Karasaki H, Kono T, Ii M, Chung DC, Bardessy N, and Kohgo Y.
  • Organizer: AACR Annual Meeting 2010, Poster Session 19
  • Place of Presentation: Washington DC
  • Year and Date: 2010-04-20
• [Book] 血管生物医学事典 第1章14 膵の血管系 (2011)
  • Author(s): 唐崎秀則、水上裕輔
  • Publisher: 日本血管生物医学会編集・朝倉書店
• [Book] 血管生物医学事典 第3章14 腫瘍血管 (2011)
  • Author(s): 笹島順平、水上裕輔
  • Publisher: 日本血管生物医学会編集・朝倉書店
• [Book] 実験医学(増刊)28巻17号 (2010)
  • Author(s): 水上裕輔、高後裕
  • Publisher: 羊土社
• [Book] 細胞42巻2号 (2010)
  • Author(s): 水上裕輔、笹島順平、高後裕
  • Publisher: 腫瘍血管新生における骨髄細胞の役割
• [Book] 胆と膵31巻5号 (2010)
  • Author(s): 唐崎秀則、水上裕輔、徳差良彦, 他
  • Publisher: 分枝型IPMNの外科治療戦略ムチン発現形質と壁在結節の有無からみたIPMNの切除適応
• [Book] 細胞工学(別冊)#巻# (2010)
  • Author(s): 水上裕輔、高後裕
  • Publisher: がん転移の臨床と基礎医学膵臓がん:膵がん転移の臨床像
• [Remarks]
  • URL: http://www.higashi-tokushukai.or.jp/clinical_study/index.php
• [Remarks]
  • URL: http://www.asahikawa-med.ac.jp/dept/mc/imed3/