| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Tumor-derived factors affect the stroma of cancer tissue. One of the key components of this response is the mobilization of the progenitors from the bone marrow (BM), which contribute toward the development of desmoplastic stroma. These BM-derived cells are involved in normal physiological processes such as tissue repair and wound healing; however, in cancer bearing hosts, these cells actively contribute toward the chaotic microenvironment. Using genetically engineered mice models for pancreatic cancer, we found that BM-progenitors are passively activated by even early stage tumors. We have identified the signaling pathways by which BM-derived cells are recruited and activated to establish malignant stroma in later stages of tumor development.
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