| Project/Area Number |
22590757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胆道学 / 膵臓学 / 嚢胞性線維症 / 単離膵管 / 抗エストロゲン剤 / ナトリウム―プロトン交換輸送体 / CFTR(cystic fibrosis transmembrane conductance regulator) / NHE(Na^+-H^+ exchange) / CFTR (cystic fibrosis transmembrane conductance regulator) / NHE (Na^+-H^+ exchange) |
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| Research Abstract |
Pancreatic juice is an alkaline fluid that contains HCO_3^- rich fluid and digestive enzymes. Na^+-H^+ exchangers (NHE) are localized in both basolateral and apical membranes of various epithelia. In the present study, to investigate the role of apical NHE in HCO_3^- secretion from pancreatic duct cells, we identified the membrane localization of apical Na^+-H^+ exchangers, measured the activity of apical Na^+-H^+ exchange, and demonstrated the mechanisms to play a role of HCO_3^- secretion by pancreatic ductal epithelium.
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