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Anti-estrogen regulates proton ion: A study looking for a new therapy of cystic fibrosis.

Research Project

Project/Area Number 22590757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNagoya University

Principal Investigator

YAMAMOTO Akiko  名古屋大学, 総合保健体育科学センター, 准教授 (60402385)

Co-Investigator(Kenkyū-buntansha) ISHIGURO Hiroshi  名古屋大学, 総合保健体育科学センター, 教授 (90303651)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胆道学 / 膵臓学 / 嚢胞性線維症 / 単離膵管 / 抗エストロゲン剤 / ナトリウム―プロトン交換輸送体 / CFTR(cystic fibrosis transmembrane conductance regulator) / NHE(Na^+-H^+ exchange) / CFTR (cystic fibrosis transmembrane conductance regulator) / NHE (Na^+-H^+ exchange)
Research Abstract

Pancreatic juice is an alkaline fluid that contains HCO_3^- rich fluid and digestive enzymes. Na^+-H^+ exchangers (NHE) are localized in both basolateral and apical membranes of various epithelia. In the present study, to investigate the role of apical NHE in HCO_3^- secretion from pancreatic duct cells, we identified the membrane localization of apical Na^+-H^+ exchangers, measured the activity of apical Na^+-H^+ exchange, and demonstrated the mechanisms to play a role of HCO_3^- secretion by pancreatic ductal epithelium.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] Structure and function of the pancreas in the polycystic kidney rat.2012

    • Author(s)
      Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H
    • Journal Title

      Pancreas

      Volume: 41 Pages: 1292-1298

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.2012

    • Author(s)
      Song Y, Yamamoto A, Steward MC, Ko SB, Stewart AK , Soleimani M, Liu BC, Kondo T, Jin CX, Ishiguro H. Ishiguro H.
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 303

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium.2012

    • Author(s)
      Ishiguro H, Yamamoto A, Nakakuki M, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Mochimaru Y.
    • Journal Title

      Nagoya J Med Sci

      Volume: 74 Pages: 1-18

    • NAID

      120003837113

    • URL

      http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7412/01_Ishiguro.pdf

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.2012

    • Author(s)
      Y. Song
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 303 Issue: 8 Pages: C815-C824

    • DOI

      10.1152/ajpcell.00151.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【生活習慣と膵疾患】エタノールが膵導管細胞機能に及ぼす影響2012

    • Author(s)
      山本明子
    • Journal Title

      膵臓

      Volume: 27 Pages: 121-131

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【再発性膵炎の病態と治療】 導管細胞機能からみた膵炎再発の原因とその対策2012

    • Author(s)
      洪 繁
    • Journal Title

      胆と膵

      Volume: 33 Pages: 303-309

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium2012

    • Author(s)
      H. Ishiguro
    • Journal Title

      Nagoya J Med Sci

      Volume: 74 Pages: 1-18

    • NAID

      120003837113

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of pancreatic stone formation in chronic pancreatitis2012

    • Author(s)
      SB. Ko
    • Journal Title

      Front Physiol

      Volume: 415 Pages: 3-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases2011

    • Author(s)
      Jin CX, Hayakawa T, Ko SB, Ishiguro H, Kitagawa M.
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 15 Pages: 1507-1516

    • DOI

      10.2169/internalmedicine.50.5362

    • NAID

      130000969341

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SLC26 anion exchangers of guinea pig pancreatic duct : molecular cloning and functional characterization2011

    • Author(s)
      Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko SB, Ishiguro H, Alper SL
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 301 Issue: 2 Pages: 289-303

    • DOI

      10.1152/ajpcell.00089.2011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.2011

    • Author(s)
      Ko SB, Yamamoto A, Azuma S, Song H, Kamimura K, Nakakuki M, Gray MA, Becq F, Ishiguro H, Goto H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 904-9

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2011.06.093

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microperfusion and micropuncture analysis of ductal secretion2011

    • Author(s)
      Ishiguro H, Steward MC, Yamamoto A
    • Journal Title

      The Pancreapedia Exocrine Pancreas Knowledge Base 2011

    • DOI

      10.3998/panc.2011.16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cell2011

    • Author(s)
      SB.Ko, A.Yamamoto, S.Azuma, H.Song, K.Kamimura, M.Nakakuki, MA.Gray, H.Ishiguro, et.al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 904-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis2010

    • Author(s)
      Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H
    • Journal Title

      Gastroenterology

      Volume: 138 Issue: 5 Pages: 1988-96

    • DOI

      10.1053/j.gastro.2010.01.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【膵基礎研究の新しい潮流Bench to Bedをめざして】膵導管細胞機能とCFTRの役割2010

    • Author(s)
      石黒洋、洪繁、山本明子
    • Journal Title

      胆と膵

      Volume: 31 Pages: 527-533

    • Related Report
      2010 Annual Research Report
  • [Presentation] NH4+パルス負荷による膵導管細胞内pH変化のコンピューター・シュミレーション2013

    • Author(s)
      山口 誠
    • Organizer
      第90回日本日本生理学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遺伝性肝胆膵疾患の病態と治療 ワークショップ17「わが国の嚢胞線維症患者のCFTR遺伝子変異の特徴」2012

    • Author(s)
      中莖みゆき
    • Organizer
      第54回日本消化器病学
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Model for bicarbonate secretion2012

    • Author(s)
      Hiroshi Ishiguro
    • Organizer
      Basic Science Course "Epithelial ion transport in the GI tract", United European Gastroenterology Education
    • Place of Presentation
      Hungary
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 膵疾患の遺伝的背景を探る パネルディスカッション1 「性膵炎におけるCFTR遺伝子の関与」2011

    • Author(s)
      藤木理代、石黒洋、中莖みゆき、近藤志保、山本明子、洪繁、北川元二、成瀬達
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      青森
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵疾患の遺伝的背景を探る パネルディスカッション1 「わが国の嚢胞性線維症におけるCFTR遺伝子変異」2011

    • Author(s)
      中莖みゆき、山本明子、藤木理代、石黒洋、成瀬達
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      青森
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Pancreatic duct dysfunction and pancreatitis2011

    • Author(s)
      Ishiguro H
    • Organizer
      Gordon Research Conferences; Salivary Glands & Exocrine Biology
    • Place of Presentation
      Galveston
    • Year and Date
      2011-02-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵疾患の遺伝的背景を探る パネルディスカッション1 膵液のアルカリ化障害におけるNa+-H+交換輸送体の役割 パネルディスカッション「膵炎の基礎と臨床」2010

    • Author(s)
      山本明子、石黒洋
    • Organizer
      第52回日本消化器病学会大会 DDW-Japan
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵液のアルカリ化障害におけるNa+-H+交換輸送体の役割パネルディスカッション「膵炎の基礎と臨床」2010

    • Author(s)
      山本明子
    • Organizer
      第52回日本消化器病学会大会DDW-Japan 2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Symposium"Chronic Pancreatitis: Pathogenesis to Treatment"Molecular and cellular regulation of pancreatic duct function2010

    • Author(s)
      Ishiguro H, Ko SBH, Yamamoto A
    • Organizer
      Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-07-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Fluid secretion from the pancreatic duct in PCK rats2010

    • Author(s)
      Yi L, Ishiguro H, Yamamoto A, Nakauki M, Furuya S, Nagao S, Wei M, Kondo T, Naruse S
    • Organizer
      Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-07-13
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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