Anti-estrogen regulates proton ion: A study looking for a new therapy of cystic fibrosis.
| Project/Area Number |
22590757
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
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|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 胆道学 / 膵臓学 / 嚢胞性線維症 / 単離膵管 / 抗エストロゲン剤 / ナトリウム―プロトン交換輸送体 / CFTR(cystic fibrosis transmembrane conductance regulator) / NHE(Na^+-H^+ exchange) / CFTR (cystic fibrosis transmembrane conductance regulator) / NHE (Na^+-H^+ exchange) |
|---|
| Research Abstract |
Pancreatic juice is an alkaline fluid that contains HCO_3^- rich fluid and digestive enzymes. Na^+-H^+ exchangers (NHE) are localized in both basolateral and apical membranes of various epithelia. In the present study, to investigate the role of apical NHE in HCO_3^- secretion from pancreatic duct cells, we identified the membrane localization of apical Na^+-H^+ exchangers, measured the activity of apical Na^+-H^+ exchange, and demonstrated the mechanisms to play a role of HCO_3^- secretion by pancreatic ductal epithelium.
|
Report
(4 results)
Research Products
(25 results)
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[Journal Article] Structure and function of the pancreas in the polycystic kidney rat.2012
Author(s)
Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H
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Journal Title
Pancreas
Volume: 41
Pages: 1292-1298
Related Report
Peer Reviewed
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[Journal Article] Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis2010
Author(s)
Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H
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Journal Title
Gastroenterology
Volume: 138
Issue: 5
Pages: 1988-96
DOI
Related Report
Peer Reviewed
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