| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
c-mycis known as the most famous oncogene and encodes c-MYC oncoprotein. c-MYC contributes to cell proliferation, ribosomal biosynthesis, glycolysis and apoptosis. It has been reported that regulation of c-MYC degradation is mediated by ubiquitin-proteasome pathway. However wefound that antizyme 2 protein which regulates cellular polyamine level accelerates degradation of c-MYC by the proteasome ubiquitin-independently. In this study, weshowed that novel ubiquitin independent c-MYC degradation pathway exist in the cells.
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