Challenging to the real-time in vivo diagnosis for inflammatory bowel disease by using super-magnifying endoscope.

• Project/Area Number: 22590763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: OGATA Haruhiko 慶應義塾大学, 医学部, 教授 (30177117)
• Co-Investigator(Kenkyū-buntansha): KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 超拡大内視鏡 / 炎症性腸疾患 / 迅速病理診断 / 潰瘍性大腸炎 / リアルタイム / 拡大内視鏡

Research Abstract

We have established an Super-magnifying endoscopy score (Endocytoscopy system score: ECSS) to determine the histopathological activity index of Ulcerative colitis. ECSS of intestinal mucosa of UC, i.e., the shape of and distance between crypts, and micro

Research Products

• [Journal Article] Applicability of second generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study. (2013)
  • Author(s): Hosoe N, Matsuoka K, Naganuma M, Ida Y, Ishibashi Y, Kimura K, Yoneno K, Usui S, Kashiwagi K, Hisamatsu T, Inoue N, Kanai T, Imaeda H, Ogata H, Hibi T.
  • Journal Title: Gastroenterol Hepatol. Volume: 28 Issue: 7 Pages: 1174-1179
  • DOI: 10.1111/jgh.12203
  • Peer Reviewed
• [Journal Article] Long-term prognosis of patients with ulcerative colitis treated with cytapheresis therapy. (2013)
  • Author(s): Takayama T, Kanai T, Matsuoka K, Okamoto S, Sujino T, Mikami Y, Hisamatsu T, Yajima T, Iwao Y, Ogata H, Hibi T
  • Journal Title: J Crohns Colitis Volume: 7(2)
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis. (2012)
  • Author(s): Ogata H, Kato J, Hirai F, Hida N, Matsui T, Matsumoto T, Koyanagi K, Hibi T
  • Journal Title: Inflamm Bowel Dis Volume: 18(5) Pages: 803-808
  • Peer Reviewed
• [Journal Article] The use of infliximab in the prevention of postsurgical recurrence in polysurgery Crohn's disease patients: a pilot open-labeled prospective study. (2012)
  • Author(s): Sakuraba A, Sato T, Matsukawa H, Okamoto S, Takaishi H, Ogata H, Iwao Y, Hibi T
  • Journal Title: Int J Colorectal Dis Volume: 27(7) Pages: 947-52
  • Peer Reviewed
• [Journal Article] Intermittent granulocyte and monocyte apheresis versus mercaptopurine for maintaining remission of ulcerative colitis: a pilot study. (2012)
  • Author(s): Sakuraba A
  • Journal Title: Ther Apher Dial. Volume: 16(3) Issue: 3 Pages: 213-218
  • DOI: 10.1111/j.1744-9987.2012.01064.x
  • Peer Reviewed
• [Journal Article] Long-term prognosis of patients with ulcerative colitis treated with cytapheresis therapy. (2012)
  • Author(s): Takayama T, Kanai T, Matsuoka K, Okamoto S, Sujino T, Mikami Y, Hisamatsu T, Yajima T, Iwao Y, Ogata H, Hibi T.
  • Journal Title: Journal of Crohns and Colitis Volume: 7 Issue: 2 Pages: e49-e54
  • DOI: 10.1016/j.crohns.2012.05.005
  • Peer Reviewed
• [Journal Article] T-helper 17 and Interleukin-17-Producing Lymphoid Tissue Inducer-Like T Cells Make Different Contributions to Colitis in Mice. (2012)
  • Author(s): Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
  • Journal Title: Gastroenterology Volume: 143 Issue: 5 Pages: 1288-1297
  • DOI: 10.1053/j.gastro.2012.07.108
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis. (2012)
  • Author(s): Ogata H
  • Journal Title: Inflamm Bowel Dis. Volume: May;18(5) Issue: 5 Pages: 803-808
  • DOI: 10.1002/ibd.21853
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis (2012)
  • Author(s): Ogata H, Kato J, Hirai F, Hida N, Matsui T, Matsumoto T, Koyanagi K, Hibi T
  • Journal Title: Inflamm Bowel Dis Volume: 18 Pages: 803-808
  • Peer Reviewed
• [Journal Article] Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease. (2011)
  • Author(s): Miyoshi J, Yajima T, Okamoto S, Matsuoka K, Inoue N, Hisamatsu T, Shimamura K, Nakazawa A, Kanai T, Ogata H, Iwao Y, Mukai M, Hibi T
  • Journal Title: J Gastroenterol Volume: 46(9) Pages: 1056-63
  • NAID: 10029706720
  • Peer Reviewed
• [Journal Article] Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis. (2011)
  • Author(s): Bessho R, Kanai T, Hosoe N, Kobayashi T, Takayama T, Inoue N, Mukai M, Ogata H, Hibi T.
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 1197-202
  • NAID: 10030294462
  • Peer Reviewed
• [Journal Article] Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells. (2011)
  • Author(s): Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T
  • Journal Title: Gastroenterology. Volume: 141(3) Pages: 1014-23
  • Peer Reviewed
• [Journal Article] A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography. (2011)
  • Author(s): Hosoe N, Imaeda H, Okamoto S, Bessho R, Ida Y, Kobayashi S, Kanai T, Hibi T, Ogata H.
  • Journal Title: Gastrointest Endosc Volume: 74(3) Pages: 690-691
  • Peer Reviewed
• [Journal Article] Evaluation of small-intestinal abnormalities in adult patients with Henoch-Schonlein purpura using video capsule. (2011)
  • Author(s): Ichikawa R, Hosoe N, Imaeda H, Takabayashi K, Bessho R, Ida Y, Naganuma M, Hisamatsu T, Inoue N, Kanai T, Iwao Y, Mukai M, Hibi T, Ogata H.
  • Journal Title: Endoscopy Volume: 43(2) Pages: 162-163
  • Peer Reviewed
• [Journal Article] CD4+CD25+ regulatory T cells suppress the development of colitis by blocking the differentiation from Th17 to alternative Th1 cells (2011)
  • Author(s): Sujino T, Kanai T, Mikami Y, Ono Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Dan R Littman, Hibi T
  • Journal Title: Gastroenterology Volume: 141 Pages: 1014-1023
  • Peer Reviewed
• [Journal Article] Evaluation of small-intestinal abnormalities in adult patients with Henoch-Schonlein purpura using video capsule (2011)
  • Author(s): Ichikawa R, Hosoe N, Imaeda H, Takabayashi K, Bessho R, Ida Y, Naganuma M, Hisamatsu T, Inoue N, Kanai T, Iwao Y, Mukai M, Hibi T, Ogata H
  • Journal Title: Endoscopy Volume: 43 Pages: 162-163
  • Peer Reviewed
• [Journal Article] Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis (2011)
  • Author(s): Bessho R, Kanai T, Hosoe N, Kobayashi T, Takayama T, Inoue N, Mukai M, Qgata H, Hibi T
  • Journal Title: J Gastroenterol Volume: 46 Pages: 1197-1202
  • NAID: 10030294462
  • Peer Reviewed
• [Journal Article] A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography (with videos) (2011)
  • Author(s): Hosoe N, Imaeda H, Okamoto S, Bessho R, Saito R, Ida Y, Kobayashi S, Kanai T, Hibi T, Ogata H
  • Journal Title: Gastrointest Endosc Volume: 74 Pages: 690-691
  • Peer Reviewed
• [Journal Article] Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells (2011)
  • Author(s): Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T
  • Journal Title: Gastroenterology Volume: 141 Pages: 1014-1023
  • Peer Reviewed
• [Journal Article] Successful treatment of a large hyperplastic polyp in the jejunum by using single-balloon enteroscopy. (2011)
  • Author(s): Nakamura S, Imaeda H, Sujino T, Hosoe N, Naganuma M, Ebinuma H, Okamoto S, Nishizawa T, Takahashi M, Iwao Y, Kameyama K, Mukai M, Ogata H, Hibi T.
  • Journal Title: Gastrointest Endosc. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Upregulated IL-7 receptor (alpha) expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. (2011)
  • Author(s): Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M
  • Journal Title: J Immunol Volume: 186 Pages: 2623-2632
  • Peer Reviewed
• [Journal Article] In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope. (2010)
  • Author(s): Hosoe N, Kobayashi T, Kanai T, Bessho R, Takayama T, Inoue N, Imaeda H, Iwao Y, Kobayashi S, Mukai M, Ogata H, Hibi T.
  • Journal Title: Gastrointest Endosc. Volume: 72(3) Pages: 643-646
  • Peer Reviewed
• [Journal Article] Partial regression of duodenal lesions of intestinal follicular lymphoma after antibiotic treatment. (2010)
  • Author(s): Yaguchi T, Imaeda H, Kizaki M, Hosoe N, Suzuki H, Ogata H, Iwao Y, Kameyama K, Ikeda Y, Hibi T.
  • Journal Title: Dig Endosc. Volume: 22 Pages: 316-318
  • NAID: 10028187355
  • Peer Reviewed
• [Journal Article] Clinical results of observation of the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope. (2010)
  • Author(s): Imaeda H, Hosoe N, Nakamizo H, Kashiwagi K, Suzuki H, Saito Y, Suganuma K, Ida Y, Matsuzaki J, Iwasaki E, Iwao Y, Ogata H, Hibi T.
  • Journal Title: J Gastroenterol Hepatol. Volume: 25 Pages: 1850-1854
  • Peer Reviewed
• [Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis. (2010)
  • Author(s): Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T.
  • Journal Title: Eur J Immunol. Volume: 40 Pages: 2409-2422
  • Peer Reviewed
• [Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. (2010)
  • Author(s): Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
  • Journal Title: Gastroenterology Volume: 139 Pages: 882-892
  • Peer Reviewed
• [Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset. (2010)
  • Author(s): Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
  • Journal Title: J Immunol. Volume: 184 Pages: 2671-2676
  • Peer Reviewed
• [Journal Article] MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis. (2010)
  • Author(s): Ojiro K, Ebinuma H, Nakamoto N, Wakabayashi K, Mikami Y, Ono Y, Po-Sung C, Usui S, Umeda R, Takaishi H, Yamagishi Y, Saito H, Kanai T, Hibi T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 399 Pages: 744-749
  • Peer Reviewed
• [Presentation] Feasibility of Evaluating the Mucosal Inflammation in Ulcerative Colitis by Using a Second Generation Colon Capsule Endoscope. (2012)
  • Author(s): Hosoe N, Matsuoka K, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Usui S, Kashiwagi K, Hisamatsu T, Inoue N, Kanai T, Imaeda H, Hibi T, Ogata H
  • Organizer: Asian Pacific Digestive Week 2012
  • Place of Presentation: Bangkok
• [Presentation] Feasibility of Evaluating the Mucosal Inflammation in Ulcerative Colitis by Using a Second Generation Colon Capsule Endoscope (2012)
  • Author(s): Ogata H
  • Organizer: Asian pacific disease week
  • Place of Presentation: バンコク
• [Presentation] カプセル内視鏡による低用量アスピリン内服患者の小腸病変サーベイランス (2012)
  • Author(s): 緒方晴彦
  • Organizer: JDDW 2012
  • Place of Presentation: 神戸
• [Presentation] Real-time in vivo pathological diagnosis by using Endocytoscopy system. (2011)
  • Author(s): Ogata H.
  • Organizer: The 81th Annual Meeting of The JSGE
  • Place of Presentation: Nagoya
  • Year and Date: 2011-08-18
• [Presentation] Real-time in vivo pathological diagnosis by using Endocytoscopy system (2011)
  • Author(s): Haruhiko Ogata
  • Organizer: The 81th Annual Meeting of The JSGE
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-08-18
• [Presentation] 日比紀文:カプセル内視鏡による成人発症Henoch-Schoenlein 紫斑病の小腸病変の検討 (2011)
  • Author(s): 細江直樹、緒方晴彦
  • Organizer: 第97回日本消化器病学会総会 パネルディスカッション
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Treatment of Ulcerative Colitis in Japan (2011)
  • Author(s): Haruhiko Ogata
  • Organizer: UC Expert Meeting in Tokyo
  • Place of Presentation: 東京
  • Year and Date: 2011-01-25
• [Presentation] In vivo visualization and evaluation of colorectal inflammation in ulceretivecolitis by a newly integrated endocytoscopy. (2011)
  • Author(s): Kimura K, Kanai T, Bessho R, Hosoe N, Kobayashi T, Takayama T, Inoue N, Mukai M, Ogata H, and Hibi T
  • Organizer: Digestive Disease Week2011
  • Place of Presentation: Chicago
• [Presentation] Analysis of Problems with Methodology for the Practical Use of Magnetically Guided Capsule Endoscopy. (2011)
  • Author(s): Hosoe N, Ogata H, Rey JF, Ohtsuka K, Ogata N, Ikeda K, Aihara H, Pangtay I, Hibi T, Kudo S, and Tajiri H
  • Organizer: Digestive Disease Week2011
  • Place of Presentation: Chicago
• [Presentation] Analysis of problems with methodology for the practical use of magnetically guided capsule endoscopy (2011)
  • Author(s): Hosoe N, Ogata H, Rey JF, Ohtsuka K, Ogata N, Ikeda K, Aihara H, Pangtay I, Hibi T, Kudo S, Tajiri H
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: Chicago USA
• [Presentation] Oral tacrolimus therapy is useful for patients with intractable ulcerative colitis : A result of post-marketing analysis (2011)
  • Author(s): Inoue N, Ichikawa R, Miyoshi J, Matsuoka K, Hisamatsu T, Okamoto S, Ogata H, Iwao Y, Kanai T, Hibi T
  • Organizer: 15th International Congress of Mucosal Immunology
  • Place of Presentation: Paris France
• [Presentation] In vivo visualization and evaluation of colorectal inflammation in ulcerative colitis by a newly integrated endocytoscopy (2010)
  • Author(s): Haruhiko Ogata
  • Organizer: 18^<th> United European Gastroenterology Week
  • Place of Presentation: Centre Conventions International Barcelona (Spain)
  • Year and Date: 2010-10-26
• [Presentation] Long-term prognosis of ulcerative colitis patients treated with cytoapheresis therapy (2010)
  • Author(s): Takayama T, Okamoto S, Naganuma M, Saito R, Sujino T, Mikami T, Inoue N, Hisamatsu T, Yajima T, Matsuoka K, Ogata H, Kanai T, Iwao Y and Hibi T
  • Organizer: 5th Japan-Korea IBD Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-02
• [Presentation] Proposal for the Asian Organization for the Study of IBD (2010)
  • Author(s): Haruhiko Ogata
  • Organizer: 5^<th> Japan-Korea IBD Symposium
  • Place of Presentation: Sheraton Grande Walkerhill Hotel (Korea)
  • Year and Date: 2010-10-02
• [Presentation] IBD診断・治療の新時代 (2010)
  • Author(s): 緒方晴彦
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-15
• [Presentation] In vivo visualization and evaluation of colorectal inflammation in ulcerative colitis by a newly integrated endocytoscopy-correlation analysis with conventional histology (2010)
  • Author(s): Haruhiko Ogata
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] Real-time in vivo diagnosis of trophozoites in patients with amoebic colitis using newly developed endocytoscope. (2010)
  • Author(s): Hosoe N, Kobayashi T, Kanai T, Bessho R, Takayama T, Inoue N, Imaeda H, Ogata H, and Hibi T
  • Organizer: 18th United European Gastroenterology Week
  • Place of Presentation: Barcelona
• [Book] Crohn's Disease and Ulcerative Colitis. (Chapter 24. Endoscopic Assessment of Disease Activity and Mucosal Healing in Inflammatory Bowel Disease.) (2012)
  • Author(s): Haruhiko Ogata and Toshifumi Hibi
  • Publisher: Speinger
• [Book] Crohn’s Disease and Ulcerative Colitis. (Chapter 24. Endoscopic Assessment of Disease Activity and Mucosal Healing in Inflammatory Bowel Disease.) (2012)
  • Author(s): Haruhiko Ogata
  • Total Pages: 10
  • Publisher: Speinger
• [Book] Crohn's Disease and Ulcerative Colitis. (Chapter 24. Endoscopic Assessment of Disease Activity and Mucosal Healing in Inflammatory Bowel Disease.) (2012)
  • Author(s): Haruhiko Ogata, Toshifumi Hibi
  • Publisher: Speinger