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Development of systems with endoscopic ultrasonography for diagnosis and treatment of bilio-pancreatic diseases

Research Project

Project/Area Number 22590764
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKinki University

Principal Investigator

KITANO Masayuki  近畿大学, 医学部, 准教授 (50314571)

Co-Investigator(Kenkyū-buntansha) KUDO Masatoshi  近畿大学, 医学部, 教授 (10298953)
NISHIO Kazuto  近畿大学, 医学部, 教授 (10208134)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords超音波内視鏡学 / 膵臓病学 / 検査診断システム / 消化器内視鏡学 / 超音波内視鏡 / 内視鏡 / 造影ハーモニック法 / 超音波内視鏡下穿刺術 / 超音波内視鏡ガイド下穿刺術
Research Abstract

The usefulness of contrast-enhanced harmonic endoscopic ultrasonography for characterization of solid tumors in the pancreas, characterization of intra-abdominal lesions of undetermined origin and estimation of malignant potential of gastrointestinal stromal tumors was evaluated. In comparison with the other imaging methods, this novel technique improved the diagnostic ability for these diseases. Endoscopic ultrasonography guided broad plexus neurolysis achieved better pain relief than endoscopic ultrasonography guided celiac plexus neurolysis. Development of endoscopic ultrasonography guided drainage allowed salvage drainage treatment for obstruction of bilio-pancreatic system after unsuccessful transpapillary or surgical drainage.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (56 results)

All 2013 2012 2011 2010

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (30 results) (of which Invited: 3 results) Book (4 results)

  • [Journal Article] Characterization of small solid tumors in the pancreas: the value of contrast-enhanced harmonic endoscopic ultrasonography2012

    • Author(s)
      Kitano M, Kudo M, Yamao K, Takagi T, Sakamoto H, Komaki T, Kamata K, Imai H, Chiba Y, Okada M, Murakami T, Takeyama Y
    • Journal Title

      American Journal of Gastroenterology

      Volume: 107 Issue: 2 Pages: 303-310

    • DOI

      10.1038/ajg.2011.354

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer2012

    • Author(s)
      Sakamoto H, Kimura H, Sekijima M, Matsumoto K, Arao T, Chikugo T, Yamada Y, Kitano M, Ito A, Takeyama Y, Kudo M, Nishio K
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 42 Issue: 2 Pages: 105-112

    • DOI

      10.1093/jjco/hyr178

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound: contrast enhancement2012

    • Author(s)
      Kitano M, Sakamoto H, Kudo M
    • Journal Title

      Gastrointestinal Endoscopy Clinics of North America

      Volume: 22 Issue: 2 Pages: 349-358

    • DOI

      10.1016/j.giec.2012.04.013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcatheter endoscopy for pancreaticobiliary duct diseases (with videos)2012

    • Author(s)
      Sakamoto H, Kitano M, Kamata K, Miyata T, Kadosaka K, Imai H, Takeyama Y, Kudo M
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 76 Issue: 4 Pages: 892-899

    • DOI

      10.1016/j.gie.2012.06.012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of malignant potential of GI stromal tumors by contrast-enhanced harmonic EUS (with videos)2011

    • Author(s)
      Sakamoto H, Kitano M, Matsui S, Kamata K, Komaki T, Imai H, Dote K, Kudo M
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 73 Issue: 2 Pages: 227-37

    • DOI

      10.1016/j.gie.2010.10.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasonography and contrast-enhanced endoscopic ultrasonography2011

    • Author(s)
      Kitano M, Kudo M, Sakamoto H, Komaki T
    • Journal Title

      Pancreatology

      Volume: 11 Suppl 2 Issue: 2 Pages: 28-33

    • DOI

      10.1159/000323493

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasonography-guided biliary drainage: evaluation of a choledochoduodenostomy technique2011

    • Author(s)
      Komaki T, Kitano M, Sakamoto H, Kudo M
    • Journal Title

      Pancreatology

      Volume: 11 Suppl 2 Issue: 2 Pages: 47-51

    • DOI

      10.1159/000323508

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound-guided neurolysis in pancreatic cancer2011

    • Author(s)
      Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kudo M
    • Journal Title

      Pancreatology

      Volume: 11 Suppl 2 Issue: 2 Pages: 52-58

    • DOI

      10.1159/000323513

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New techniques and future perspective of EUS for the differential diagnosis of pancreatic malignancies: contrast harmonic imaging2011

    • Author(s)
      Kitano M, Sakamoto H, Komaki T, Kudo M
    • Journal Title

      Digestive Endoscopy

      Volume: 23 Suppl 1 Issue: s1 Pages: 46-50

    • DOI

      10.1111/j.1443-1661.2011.01146.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of malignant potential of GIST by contrast-enhanced harmonic EUS (with video).2011

    • Author(s)
      Sakamoto H, Kitano M, Matsui S, Kamata K, Komaki T, Imai H, Dote K, Kudo M
    • Journal Title

      Gastrointest Endosc

      Volume: 73 Pages: 227-237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound (EUS)-guided transluminal endoscopic removal of gallstones.2011

    • Author(s)
      Kamata K, Kitano M, Kudo M, Imai H, Sakamoto H, Komaki T
    • Journal Title

      Endoscopy

      Volume: 42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic ductal drainage by endoscopic ultrasound-assisted rendezvous technique for pain caused by ductal stricture with chronic pancreatitis.2010

    • Author(s)
      Das K, Kitano M, Komaki T, Sakamoto H, Noda K, Suetomi Y, Kudo M
    • Journal Title

      Digestive Endoscopy

      Volume: 22 Issue: 3 Pages: 217-219

    • DOI

      10.1111/j.1443-1661.2010.00980.x

    • NAID

      10028187012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos)2010

    • Author(s)
      Xia Y, Kitano M, Kudo M, Imai H, Kamata K, Sakamoto H, Komaki T
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 72 Issue: 3 Pages: 637-642

    • DOI

      10.1016/j.gie.2010.04.013

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of pancreatic tumors by endoscopic ultrasonography2010

    • Author(s)
      Sakamoto H, Kitano M, Kamata K, El-Masry M, Kudo M
    • Journal Title

      World Journal of Radiology

      Volume: 28 Issue: 4 Pages: 122-134

    • DOI

      10.4329/wjr.v2.i4.122

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of subepithelial tumors in the upper gastrointestinal tract by endoscopic ultrasonography2010

    • Author(s)
      Sakamoto H, Kitano M, Kudo M
    • Journal Title

      World Journal of Radiology

      Volume: 28 Issue: 8 Pages: 289-297

    • DOI

      10.4329/wjr.v2.i8.289

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound (EUS)-guided transluminal endoscopic removal of gallstones2010

    • Author(s)
      Kamata K, Kitano M, Kudo M, Imai H, Sakamoto H, Komaki T
    • Journal Title

      Endoscopy

      Volume: 42 Suppl 2 Issue: S 02 Pages: E331-E332

    • DOI

      10.1055/s-0030-1255941

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] EUS-guided broad plexus neurolysis over the superior mesenteric artery using a 25-gauge needle2010

    • Author(s)
      Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, Takeyama Y, Kudo M
    • Journal Title

      American Journal of Gastroenterology

      Volume: 105 Issue: 12 Pages: 2599-2606

    • DOI

      10.1038/ajg.2010.339

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos).2010

    • Author(s)
      Xia Y, Kitano M, Kudo M, Imai H, Kamata K, Sakamoto H, Komaki T
    • Journal Title

      Gastrointest Endosc

      Volume: 72 Pages: 637-642

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EUS-guided broad plexus-neurolysis over the superior mesenteric artery using a 25 gauge needle.2010

    • Author(s)
      Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, Taketyama Y, Kudo M
    • Journal Title

      Am J Gastroenterol

      Volume: 105 Pages: 2599-2606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic ductal drainage by endoscopic ultrasound-assisted rendezvous technique for pain caused by ductal stricture with chronic pancreatitis.2010

    • Author(s)
      Das K, Kitano M, Komaki T, Sakamoto H, Noda K, Suetomi Y, Kudo M
    • Journal Title

      Digest Endosc

      Volume: 22 Pages: 217-219

    • NAID

      10028187012

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of pancreatic tumors by endoscopic ultrasonography.2010

    • Author(s)
      Sakamoto H, Kitano M, kamata K, El-Masry M, Kudo M
    • Journal Title

      World J Radiol

      Volume: 2 Pages: 122-134

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of subepithelial tumors in the upper gastrointestinal tract by endoscopic ultrasonography.2010

    • Author(s)
      Sakamoto H, Kitano M, Kudo M
    • Journal Title

      World J Radiol

      Volume: 2 Pages: 289-297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Therapeutic EUS - expanding horizons (Invited lecture)2013

    • Author(s)
      Kitano M
    • Organizer
      14th Annual Conference of Society of Gastrointestinal Endoscopy in India
    • Place of Presentation
      Gurgaon, India
    • Related Report
      2012 Final Research Report
  • [Presentation] Therapeutic EUS - expanding horizons2013

    • Author(s)
      Kitano M
    • Organizer
      14th Annual Conference of Society of Gastrointestinal Endoscopy in India
    • Place of Presentation
      Gurgaon, India
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Contrast enhanced EUS & elastography (Invited lecture)2012

    • Author(s)
      Kitano M
    • Organizer
      The 6th Meeting of the Society of Gastrointestinal Intervention
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Better imaging, better diagnosis? (Invited lecture)2012

    • Author(s)
      Kitano M
    • Organizer
      18th International Symposium on Endoscopic Ultrasonography
    • Place of Presentation
      Saint Petersburg, Russia
    • Related Report
      2012 Final Research Report
  • [Presentation] Drastic improvement of patency of covered self-expandable metal stents for distal billiary obstruction caused by pancreatic carcinomas: a randomized multicenter study comparing covered and uncovered stents2012

    • Author(s)
      Kitano M
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS-guided drainage for biliary obstruction after unsuccessful ERCP2012

    • Author(s)
      Kitano M
    • Organizer
      第83回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS-guided drainage for biliary obstruction after unsuccessful ERCP2012

    • Author(s)
      Kitano M
    • Organizer
      第83回日本消化器内視鏡学会総会
    • Place of Presentation
      東京、グランドプリンスホテル新高輪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Drastic improvement of patency of covered self-expandable metal stents for distal billiary obstruction caused by pancreatic carcinomas: a randomized multicenter study comparing covered and uncovered stents.2012

    • Author(s)
      Kitano M
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego、USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Better imaging, better diagnosis?2012

    • Author(s)
      Kitano M
    • Organizer
      18th International Symposium on Endoscopic Ultrasonography
    • Place of Presentation
      Saint Petersburg, Russia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Contrast enhanced EUS & elastography2012

    • Author(s)
      Kitano M
    • Organizer
      The 6th Meeting of the Society of Gastrointestinal Intervention
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Contrast-enhanced harmonic EUS2011

    • Author(s)
      Kitano M
    • Organizer
      14th National Academic EUS Conference, 4th Shanghai International Pancreatology Forum
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recent advanced in diagnostic EUS2011

    • Author(s)
      Kitano M
    • Organizer
      Asian Pacific Digestive Week 2011
    • Place of Presentation
      Shingapore
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] EUS elatography, contrast-enhanced EUS2011

    • Author(s)
      Kitano M
    • Organizer
      4th Asian-Oceanic Pancreatic Association & KPBA
    • Place of Presentation
      Jeju, Krea
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 超音波内視鏡による診断と治療2011

    • Author(s)
      北野雅之
    • Organizer
      日本消化器病学会近畿支部第37回教育講演会
    • Place of Presentation
      大阪(大阪国際交流センター)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] EUS-guided gallbladder drainage as an alternative treatment for malignant biliary obstruction after unsuccessful ERCP : Outcomes of long term follow-up2011

    • Author(s)
      Kitano M, et al
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contrast-enhanced harmonic EUS in diagnosing pancreatic neoplasms2011

    • Author(s)
      Kitano M, et al
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      青森(ホテル青森)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 造影ハーモニックEUSシステムの開発と臨床応用2011

    • Author(s)
      北野雅之, ほか
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      青森(青森市文化会館)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 造影ハーモニックEUS システムの開発と臨床応用2011

    • Author(s)
      北野雅之
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Contrast-enhance harmonic EUS in diagnosing pancreatic neoplasms2011

    • Author(s)
      Kitano M
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS-guided gallbladder drainage as an alternative treatment for malignant biliary obstruction after unsuccessful ERCP: Outcomes of long term follow-up2011

    • Author(s)
      Kitano M
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of small pancreatic neoplasms by contrast-enhanced harmonic EUS2010

    • Author(s)
      Kitano M
    • Organizer
      18th United European Gastroenterology Week
    • Place of Presentation
      Barcelona、Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS ガイド下治療のコツと工夫2010

    • Author(s)
      北野雅之
    • Organizer
      第80回日本消化器内視鏡学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Contrast-enhanced harmonic endosonography in diagnosing pancreatic diseases2010

    • Author(s)
      Kitano M
    • Organizer
      Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵疾患に対する超音波内視鏡ガイド下ドレナージ術2010

    • Author(s)
      北野雅之
    • Organizer
      日本超音波医学会 第83回学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Contrast-enhanced harmonic EUS for diagnosis of pancreatic tumors2010

    • Author(s)
      Kitano M
    • Organizer
      第79回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS-guided choledochoduodenostomy followed by endoscopic antegrade biliary stenting via the fistula for treatment of obstructive jaundice with duodenal stenosis2010

    • Author(s)
      Kitano M
    • Organizer
      Digestive Disease Week 2010
    • Place of Presentation
      New Orleans、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] EUS-guided gallbladder drainage for treatment of acute cholecystitis and obstructive jaundice2010

    • Author(s)
      Kitano M
    • Organizer
      Digestive Disease Week 2010
    • Place of Presentation
      New Orleans、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of small pancreatic neoplasms by contrast-enhanced harmonic EUS.2010

    • Author(s)
      Kitano M, Takagi T, Sakamoto H, Komaki T, Imai H, Kamata K, Yamao K, Kudo M
    • Organizer
      18th United European Gastroenterology Week (UEGW) 2010
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] Contrast agents and elastgraphy. New generation of EUS?2010

    • Author(s)
      Kitano M
    • Organizer
      Endoscopic Ultrasonography Live 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] State of the Art I ; Contrast harmonic imaging.2010

    • Author(s)
      Kitano M
    • Organizer
      17th International symposium on endoscopic ultrasonography (EUS) 2010
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Book] Interventional EUS の極意「EUS-GBD のコツ」. 胆膵内視鏡治療-手技の極意とトラブルシューティング(分担執筆)2012

    • Author(s)
      北野雅之
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 超音波内視鏡ガイド下穿刺術. 消化器内視鏡ハンドブック(分担執筆)2012

    • Author(s)
      北野雅之, 他
    • Publisher
      日本メディカルセンター
    • Related Report
      2012 Final Research Report
  • [Book] 拡張膵管に対する治療. EUS 下穿刺術-Interventional EUS の基礎と実践テクニック-(分担執筆)2011

    • Author(s)
      北野雅之
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 膵癌の診断と治療方針・疼痛対策. 今日の消化器疾患治療指針(分担執筆)2010

    • Author(s)
      北野雅之、工藤正俊
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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