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Role of prostanoids in the bone marrow derived endothelial cells

Research Project

Project/Area Number 22590765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

OKADA Motoi  旭川医科大学, 医学部, 講師 (80431427)

Co-Investigator(Kenkyū-buntansha) KAWABE Junichi  旭川医科大学, 医学部, 特任准教授 (10400087)
Co-Investigator(Renkei-kenkyūsha) YUHKI Kouiti  旭川医科大学, 医学部, 准教授 (80302420)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords臨床心血管病態学 / プロスタノイド / 内皮前駆細胞 / プロスタグランジン / 動脈硬化
Research Abstract

We clarified the role of vascular prostanoids, i.e. prostacyclin and thromboxane in the bone marrow-derived endothelial cells (EPC). EPC expressed their specific receptor, IP and TP respectively. We observed the functional changed of EPCs derived from IP- or TP-deleted mice using injured femoral artery vascular remodeling and peripheral ischemic models. Finally we found that PGI2 and TXA2 strictly regulated the function of EPCs and contribute to the pathogenesis of vascular diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2013 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model2013

    • Author(s)
      Aburakawa Y, Kawabe J, Okada M,Yamauchi A, Asanome A, Kabara M,Matsuki M, Takehara N, Nakagawa N,Okumura S, Minami Y, Mizukami Y, YuhkiK, Ushikubi F, Hasebe N
    • Journal Title

      Circ J

      Volume: 77(4) Pages: 1053-1062

    • NAID

      10031139011

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model2013

    • Author(s)
      油川陽子、川辺淳一、岡田基 その他
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 4 Pages: 1053-1062

    • DOI

      10.1253/circj.CJ-12-0897

    • NAID

      10031139011

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insightsfrom knockout mouse studies2011

    • Author(s)
      Yuhki K,Kojima F, Kashiwagi H, Kawabe J, Fujino T
    • Journal Title

      Narumiya S and Ushikubi F. PharmacoTherap

      Volume: 129 Pages: 195-205

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling2010

    • Author(s)
      Kawabe J, Yuhki KI,Okada M, Kanno T, Yamauchi A, Tashiro N,Sasaki T, Okumura S, Nakagawa N,Aburakawa Y, Takehara N, Fujino T, HasebeN, Narumiya S, Ushikubi F
    • Journal Title

      Atheroscler.Thromb Vasc Biol

      Volume: 30 Pages: 464-470

    • Related Report
      2012 Final Research Report
  • [Presentation] Administration of Beraprost inhibited metastasis in lung cancer2013

    • Author(s)
      Y Minami TSasaki, S Endo, K Shibukawa, JKawabe, M Kitada, Y Ohsaki
    • Organizer
      AACR(アメリカ癌学会)
    • Place of Presentation
      米国(SanFrancisco)
    • Related Report
      2012 Final Research Report
  • [Presentation] 内皮前駆細胞を介したプロスタサイクリンの下肢虚血改善作用-血管周細胞分化による血管新生効果-2010

    • Author(s)
      浅野目晃、川辺淳一、岡田基, 他
    • Organizer
      第18回日本血管生物医学会
    • Place of Presentation
      大阪、日本
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostacyclin signal in endothelial progenitor cells is crucital for tumor neoangiogenesis and its growthS Okumura2010

    • Author(s)
      J Kawabe, T Sasaki, YMinami, N Hasebe, Y Ohski
    • Organizer
      ISHR (国際心臓研究会)
    • Place of Presentation
      日本(京都)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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