Role of prostanoids in the bone marrow derived endothelial cells
Project/Area Number |
22590765
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
OKADA Motoi 旭川医科大学, 医学部, 講師 (80431427)
|
Co-Investigator(Kenkyū-buntansha) |
KAWABE Junichi 旭川医科大学, 医学部, 特任准教授 (10400087)
|
Co-Investigator(Renkei-kenkyūsha) |
YUHKI Kouiti 旭川医科大学, 医学部, 准教授 (80302420)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 臨床心血管病態学 / プロスタノイド / 内皮前駆細胞 / プロスタグランジン / 動脈硬化 |
Research Abstract |
We clarified the role of vascular prostanoids, i.e. prostacyclin and thromboxane in the bone marrow-derived endothelial cells (EPC). EPC expressed their specific receptor, IP and TP respectively. We observed the functional changed of EPCs derived from IP- or TP-deleted mice using injured femoral artery vascular remodeling and peripheral ischemic models. Finally we found that PGI2 and TXA2 strictly regulated the function of EPCs and contribute to the pathogenesis of vascular diseases.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model2013
Author(s)
Aburakawa Y, Kawabe J, Okada M,Yamauchi A, Asanome A, Kabara M,Matsuki M, Takehara N, Nakagawa N,Okumura S, Minami Y, Mizukami Y, YuhkiK, Ushikubi F, Hasebe N
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Journal Title
Circ J
Volume: 77(4)
Pages: 1053-1062
NAID
Related Report
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[Journal Article] Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling2010
Author(s)
Kawabe J, Yuhki KI,Okada M, Kanno T, Yamauchi A, Tashiro N,Sasaki T, Okumura S, Nakagawa N,Aburakawa Y, Takehara N, Fujino T, HasebeN, Narumiya S, Ushikubi F
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Journal Title
Atheroscler.Thromb Vasc Biol
Volume: 30
Pages: 464-470
Related Report
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