| Project/Area Number |
22590766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOKAWA Hiroaki 東北大学, 大学院・医学系研究科, 教授 (00235681)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 循環器 / 内科 / 臨床 / 循器・高血圧 |
|---|
| Research Abstract |
The purpose of this study was to determine the prognostic impact of nutritional status in patients with diastolic heart failure (DHF) using our prospective observational study named the CHART-2 (Chronic Heart failure Analysis and Registry in the Tohoku district-2). At the enrollment, their nutritional status was assessed by the CONUT score, a widely used nutritional status score representing the combined impact of serum albumin, total cholesterol level, and total lymphocyte count. After adjustment by sex, age, history of CAD, Cre, LVEF, anemia, and history of cancer, CONUTS〓5 was an independent prognostic marker in the patients with DHF. Undernutrition is an important predictor for cardiac death and a novel therapeutic target in patients with DHF.
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