Investigation of ambulatory arterial stiffness index as a risk factor of cardiovascular disease

• Project/Area Number: 22590767
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KIKUYA Masahiro 東北大学, 東北メディカル・メガバンク機構, 准教授 (80361111)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 動脈硬化 / ABPM / 心血管病 / AASI / 血圧測定 / HASI

Research Abstract

Ambulatory arterial stiffness index (AASI) is an index of arterial stiffness and can be computed from ambulatory blood pressure (ABP) recordings. We found that (1) decrease in number of readings in ABP does not affect predictive accuracy of AASI for cardiovascular mortality, until the median number of readings per ABP recording is less than 35, (2) AASI computed by home blood pressure predicted cerebral infarction, (3) and had weak association with intima-media thickness of carotid artery.

Research Products

• [Journal Article] (Total 16, 2nd) Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: the Ohasama study (2012)
  • Author(s): Hashimoto T, Kikuya M, Ohkubo T, Satoh M, Imai Y et al
  • Journal Title: Am J Hypertens Volume: 25(8) Issue: 8 Pages: 883-91
  • DOI: 10.1038/ajh.2012.62
  • Peer Reviewed
• [Journal Article] (Total 17, 2nd) Plasma renin activity and thealdosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study (2012)
  • Author(s): Terata S, Kikuya M, Satoh M, Ohkubo T, Imai Y et al
  • Journal Title: J Hypertens Volume: 30(8) Pages: 1632-8
  • Peer Reviewed
• [Journal Article] (Total 17, 2nd) Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study (2012)
  • Author(s): Kanno A, Kikuya M, Ohkubo T, HashimotoT, Imai Y et al
  • Journal Title: Nephrol Dial Transplant Volume: 27(8) Issue: 8 Pages: 3218-23
  • DOI: 10.1093/ndt/gfs054
  • Peer Reviewed
• [Journal Article] Aldosterone-to-Renin Ratio as a Predictor of Stroke Under Conditions of High Sodium Intake : The Ohasama Study (2012)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hara A, Utsugi MT, Hashimoto T, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: (In press) Issue: 7 Pages: 777-83
  • DOI: 10.1038/ajh.2012.33
  • Peer Reviewed
• [Journal Article] (Total 10, 3rd);J-HOME-AI Study group. The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker (2012)
  • Author(s): Metoki H, Ohkubo T, Kikuya M, AsayamaK, Inoue R et al
  • Journal Title: J Hypertens Volume: 30(7) Issue: 7 Pages: 1478-86
  • DOI: 10.1097/hjh.0b013e328353f1fe
  • Peer Reviewed
• [Journal Article] Role of angiotensinogen and relative aldosterone excess in salt-sensitive hypertension (2012)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Imai Y.
  • Journal Title: Hypertension Volume: 59(6) Issue: 6
  • DOI: 10.1161/hypertensionaha.112.195230
  • Peer Reviewed
• [Journal Article] Predictive Value for Mortality of the Double Product at Rest Obtained by Home Blood Pressure Measurement : The Ohasama Study (2012)
  • Author(s): Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Kanno A, Obara T, Hirose T, Hara A, Hoshi H, Totsune K, Satoh H, Kondo Y, Imai Y.
  • Journal Title: Am J Hypertens Volume: 25 Issue: 5 Pages: 568-575
  • DOI: 10.1038/ajh.2012.3
  • Peer Reviewed
• [Journal Article] Role of relative aldosterone excess in salt-sensitive hypertension among African ancestry (2012)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Imai Y.
  • Journal Title: Am J Hypertens Volume: 25(4) Issue: 4 Pages: 398-9
  • DOI: 10.1038/ajh.2011.235
  • Peer Reviewed
• [Journal Article] (Total 11, 1st) Validation of the Parama-Tech PS-501 device for office blood pressuremeasurement according to the international protocol (2012)
  • Author(s): Kikuya M, Ohkubo T, Satoh M, Hashimoto T, Imai Y et al
  • Journal Title: Clin Exp Hypertens Volume: 34(1) Issue: 1 Pages: 71-3
  • DOI: 10.3109/10641963.2011.618198
  • Peer Reviewed
• [Journal Article] (Total 14, 1st) Prognostic significance of homearterial stiffness index derived from self-measurement of blood pressure: the ohasama study (2012)
  • Author(s): Kikuya M, Ohkubo T, Satoh M, Hashimoto T, Imai Y et al
  • Journal Title: Am J Hypertens Volume: 25(1) Issue: 8 Pages: 67-73
  • DOI: 10.1038/ajh.2011.67
  • Peer Reviewed
• [Journal Article] Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: the Ohasama study. (2012)
  • Author(s): Hashimoto T, Kikuya M, Ohkubo T, Satoh M, Imai Y et al. (Total 17, 2nd)
  • Journal Title: Am J Hypertens Volume: 25(8) Pages: 883-891
  • Peer Reviewed
• [Journal Article] Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study. (2012)
  • Author(s): Terata S, Kikuya M, Satoh M, Ohkubo T, Imai Y et al. (Total 17, 2nd)
  • Journal Title: J Hypertens Volume: 30(8) Pages: 1632-1638
  • Peer Reviewed
• [Journal Article] Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study. (2012)
  • Author(s): Kanno A, Kikuya M, Ohkubo T, Hashimoto T, Imai Y et al. (Total 17, 2nd)
  • Journal Title: Nephrol Dial Transplant Volume: 27(8) Pages: 3218-3223
  • Peer Reviewed
• [Journal Article] Aldosterone-to-renin ratio as a predictor of stroke under conditions of high sodium intake: the Ohasama study. (2012)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Mori T, Imai Y et al. (Total 17, 2nd)
  • Journal Title: Am J Hypertens Volume: 25(7) Pages: 777-783
  • Peer Reviewed
• [Journal Article] Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study. (2012)
  • Author(s): Inoue R, Ohkubo T, Kikuya M, Metoki H, Imai Y et al. (Total 14, 3rd)
  • Journal Title: Am J Hypertens Volume: 25(5) Pages: 568-575
  • Peer Reviewed
• [Journal Article] Prognostic significance of home arterial stiffness index derived from self-measurement of blood pressure : the Ohasama Study (2012)
  • Author(s): Kikuya M, Totsune K, et al
  • Journal Title: Am J Hypertens Volume: 25 Issue: 1 Pages: 67-73
  • DOI: 10.1038/ajh.2011.167
  • Peer Reviewed
• [Journal Article] How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? The Ohasama study (2011)
  • Author(s): Kikuya M, Staessen JA, Ohkubo T, Thijs L, Asayama K, Satoh M, Hashimoto T, Hirose T, Metoki H, Obara T, Inoue R, Li Y, Dolan E, Hoshi H, Totsune K, Satoh H, Wang JG, O' Brien E, Imai Y.
  • Journal Title: Hypertens Re Volume: 34 Issue: 3 Pages: 314-318
  • DOI: 10.1038/hr.2010.240
  • NAID: 10031163174
  • Peer Reviewed
• [Journal Article] (Total 15, 2nd) Associated factors of home versusambulatory heart rate variability in the general population: the Ohasama study (2011)
  • Author(s): Gonokami K, Kikuya M, Ohkubo T, Satoh M, Imai Y et al
  • Journal Title: Clin Exp Hypertens Volume: 33(6) Issue: 6 Pages: 404-10
  • DOI: 10.3109/10641963.2010.549269
  • Peer Reviewed
• [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population : the Ohasama study (2011)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hashimoto T, Hara A, Utsugi MT, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: J Hypertens Volume: 29 Issue: 10 Pages: 1940-1947
  • DOI: 10.1097/hjh.0b013e32834ab46a
  • Peer Reviewed
• [Journal Article] How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? the Ohasama study (2011)
  • Author(s): Kikuya M
  • Journal Title: Hypertens Res Volume: VOL.34 Pages: 314-318
  • NAID: 10031163174
  • Peer Reviewed
• [Journal Article] Serum magnesium, ambulatory blood pressure, and carotid artery alteration : the Ohasama study (2010)
  • Author(s): Hashimoto T, Hara A, Ohkubo T, Kikuya M, Shintani Y, Metoki H, Inoue R, Asayama K, Kanno A, Nakashita M, Terata S, Obara T, Hirose T, Hoshi H, Totsune K, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: 23 Issue: 9 Pages: 1292-1298
  • DOI: 10.1038/ajh.2010.94
  • Peer Reviewed
• [Journal Article] Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease : the Ohasama study (2010)
  • Author(s): Kanno A, Metoki H, Kikuya M, Terawaki H, Hara A, Hashimoto T, Asayama K, Inoue R, Shishido Y, Nakayama M, Totsune K, Ohkubo T, Imai Y.
  • Journal Title: Hypertens Res Volume: 33 Issue: 11 Pages: 1192-1198
  • DOI: 10.1038/hr.2010.139
  • NAID: 10027476176
  • Peer Reviewed
• [Journal Article] (Total 11, 2nd) Validation of the FM-800 Ambulatory Blood Pressure Monitor According tothe Association for the Advancement of Medical Instrumentation Criteria and the International Protocol (2010)
  • Author(s): Nakamura K, Kikuya M, Hara A, Hirose T, Imai Y et al
  • Journal Title: Clin Exp Hypertens Volume: 32(8) Issue: 8 Pages: 523-7
  • DOI: 10.3109/10641963.2010.496513
  • Peer Reviewed
• [Journal Article] (Total 19, 3rd)Association between Kidney Dysfunction and Silent Cerebrovascular Lesions in the General Population: the Ohasama Study (2010)
  • Author(s): Otani H, Kikuya M, Hara A, Terata S, Imai Y et al
  • Journal Title: Cerebrovascular Diseases Volume: 30(1) Issue: 1 Pages: 43-50
  • DOI: 10.1159/000313612
  • Peer Reviewed
• [Journal Article] International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators. Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations (2010)
  • Author(s): Hansen TW, Thijs L, Li Y, Boggia J, Kikuya M, Bjorklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O' Brien E, Staessen JA
  • Journal Title: Hypertensio Volume: 55 Issue: 4 Pages: 1049-1057
  • DOI: 10.1161/hypertensionaha.109.137273
  • Peer Reviewed
• [Presentation] 家庭血圧によるHome Arterial Stiffness Index(HASI)と頸動脈病変との関連:大迫研究 (2011)
  • Author(s): 菊谷昌浩
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-22
• [Presentation] 家庭血圧によるHome Arterial Stiffness Index (HASI)と頸動脈病変との関連:大迫研究 (2011)
  • Author(s): 菊谷昌浩(Total 14, 1st)
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮(招待)
  • Year and Date: 2011-10-22
• [Presentation] 家庭血圧によるHome Arterial Stiffness Index(HASI)の脳卒中発症予測能 (2010)
  • Author(s): 菊谷昌浩
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] 家庭血圧によるHome Arterial Stiffness Index (HASI)の脳卒中発症予測能 (2010)
  • Author(s): 菊谷昌浩
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16