| Project/Area Number |
22590770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Kan 東京大学, 医学部附属病院, 助教 (60422292)
TSUKAMOTO Kazuhisa 福島県立医科大学, 医学部, 教授 (20251233)
SEKI George 東京大学, 医学部附属病院, 講師 (30206619)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 臨床心血管病態学 / アンジオテンシンII / 高血圧 / 脂質代謝 / 心血管障害 / 腎障害 / PPARγアゴニスト / 心機能 / 活性酸素 / リポトキシシティ / 心機能(収縮能/拡張能) / 線維化 / PPARγ / 体外灌流モデル / 再灌流障害 / ラットモデル |
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| Research Abstract |
Effects of pioglitazone, a PPAR-γ agonist, in angiotensin II-infused rat were examined. Angiotensin II increased the serum levels and cardiac concentration of triglycerides, both of which were inhibited by pioglitazone. Cardiac function that was assessed by ex vivo Langendorff cardiac perfusion system showed that pioglitazone improved both systolic and diastolic cardiac function after transient global ischemia and reperfusion. Pioglitazone ameliorates histologic and functional cardiac damage induced by angiotensin II.
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