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A study of inhibitory effect of drug-eluting stent on the cardiacfunctional recovery from stunned or hibernated myocardium

Research Project

Project/Area Number 22590773
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

OBATA Jun-ei  山梨大学, 医学部附属病院, 講師 (60362076)

Co-Investigator(Kenkyū-buntansha) KUGIYAMA Kiyotaka  山梨大学, 大学院・医学工学総合研究部, 教授 (00225129)
WATANABE Kazuhiro  山梨大学, 医学部附属病院, 助教 (50535549)
TAKISHIMA Isao  山梨大学, 医学部附属病院, 医員 (80535534)
YANO Toshiaki  山梨大学, 医学部附属病院, 医員 (60456449)
HIRANO Mitsumasa  山梨大学, 医学部附属病院, 助教 (10436884)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords薬剤溶出性ステント / 血管内皮機能障害 / 内皮機能障害
Research Abstract

This study aimed to examine the effect of the drug released intothe circulation from the drug-eluting stent on left ventricular functional recovery ofstunned or hibernated myocardium in multicenter collaborative investigations. As a result,(1) Study for the patients with ischemic heart disease who were treated with twooverlapping stents without a gap in the same coronary artery for a de novo lesion revealedthat the neointimal proliferation in the distal bare metal stent (BMS) was more inhibitedin patients with a sirolimus-eluting stent (SES) implanted at the proximal site comparedto those with a BMS. Sirolimus may diffuse to the vessel distal to the SES, which couldpossibly suppress the neointimal hyperplasia of the distal BMS. (2) High remnantlipoproteins levels are associated with the attenuated plaque of non-culprit vesseldetected by grayscale intravascular ultrasound in patients with acute coronary syndromes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results) Book (6 results) Remarks (1 results)

  • [Journal Article] In-stent restenosis is inhibited in abare metal stent implanted distal to asirolimus-eluting stent to treat a long denovo coronary lesion with small distalvessel diameter2013

    • Author(s)
      Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata KI, KugiyamaK.
    • Journal Title

      Catheter CardiovascInterv

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-Enhanced Ultrasound Imaging of Carotid Plaque Neovascularization Is Useful for Identifying High-Risk Patients With Coronary Artery Disease.2013

    • Author(s)
      Deyama J
    • Journal Title

      Circ J

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-Stent restenosis is inhibited in a bare metal stent implanted distal to a sirolimus-eluting stent to treat a long de novo coronary lesion with small distal vessel diameter.2013

    • Author(s)
      Obata JE
    • Journal Title

      Catheter Cardiovasc Interv

      Volume: Epub ahead of print Issue: 6

    • DOI

      10.1002/ccd.24841

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound assessment of brachial endothelial vasomotor function in addition to carotid plaque echolucency for predicting cardiovascular events in patients with coronary artery disease.2013

    • Author(s)
      Nakamura T
    • Journal Title

      Int J Cardiol

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of a collateral channel dilatorfor antegrade treatment of chronic totalocclusion of a coronary artery2012

    • Author(s)
      Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata K, Kugiyama K.
    • Journal Title

      J IntervCardiol

      Volume: Vol.25, No.6 Pages: 533-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of a collateral channel dilator for antegrade treatment of2012

    • Author(s)
      Obata J
    • Journal Title

      J Interv Cardiol.

      Volume: 97 Issue: 6 Pages: 533-539

    • DOI

      10.1111/j.1540-8183.2012.00758.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes.2012

    • Author(s)
      Hirano M
    • Journal Title

      Circ J

      Volume: 76(6) Pages: 1452-60

    • NAID

      10030316382

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy.2012

    • Author(s)
      Nakamura T
    • Journal Title

      J Cardiol

      Volume: 60(1) Issue: 1 Pages: 12-7

    • DOI

      10.1016/j.jjcc.2012.02.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term progression of maximumintima-media thickness of carotid plaque is associated with future coronary eventsin patients with coronary artery disease2011

    • Author(s)
      Hirano M, Nakamura T, Kitta Y,Takishima I, Deyama J, Kobayashi T,Fujioka D, Saito Y, Watanabe K, WatanabeY, Kawabata K, Obata JE, Kugiyama K
    • Journal Title

      Atherosclerosis

      Volume: Vol.215, No.2 Pages: 507-12

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelialvasomotor dysfunction in the brachialartery predicts the short-termdevelopment of early stage renaldysfunction in patients with coronaryartery disease2011

    • Author(s)
      Nakamura T, Obata JE, Hirano M, KittaY, Sano K, Kobayashi T, Fujioka D, SaitoY, Yano T, Kawabata K, Watanabe K, WatanabeY, Mishina H, Kugiyama K.
    • Journal Title

      Int J Cardiol

      Volume: Vol.148, No.2 Pages: 183-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial vasomotor dysfunction in the brachial artery predicts the short-term development of early stage renal dysfunction in patients with coronary artery disease2011

    • Author(s)
      Nakamura T, Obata JE, et al
    • Journal Title

      International journal of cardiology

      Volume: 148(2) Pages: 183-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease2011

    • Author(s)
      Hirano M, Obata JE, et al
    • Journal Title

      Atherosclerosis

      Volume: 215(2) Pages: 507-12

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive value of serial assessment of endothelial function in chronic heart failure2011

    • Author(s)
      Takishima I, Obata JE, et al
    • Journal Title

      International journal of cardiology

      Volume: (Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment ofcarotid plaque echolucency in addition toplaque size increases the predictive valueof carotid ultrasound for coronaryevents in patients with coronaryartery disease and mild carotidatherosclerosis2010

    • Author(s)
      Hirano M, Nakamura T, Kitta Y, Sano K,Kodama Y, Kobayashi T, Fujioka D, Saito Y,Yano T, Watanabe K, Watanabe Y, KawabataK, Obata JE, Kugiyama K.
    • Journal Title

      Atherosclerosis

      Volume: Vol.211, No.2 Pages: 451-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of carotid plaque echolucency in addition to plaque size increases the predictive value of carotid ultrasound for cornary events in patients with coronary artery disease and mild carotid atherosclerosis.2010

    • Author(s)
      Hirano M, et al.
    • Journal Title

      Atherosclerosis

      Volume: 211(2) Pages: 451-5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of bezafibrate and pravastatin in patients with coronary artery disease and high levels of remnant lipoprotein.2010

    • Author(s)
      Sano K, et al.
    • Journal Title

      Circ J

      Volume: 74(8) Pages: 644-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High plasma levels of macrophage migration inhibitory factor are associaced with adverse long-term outcome in patients with stable coronary artery disease and impaired glucose tolerance or type 2 diabetes mellitus2010

    • Author(s)
      Makino A, et al.
    • Journal Title

      Atherosclerosis

      Volume: 213(2) Pages: 573-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Coronary endothelial vasomotor function after drug-eluting stent implantation in infarct-related coronary artery2013

    • Author(s)
      Obata JE
    • Organizer
      第22回 日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In-stent Restenosis is Inhibited in a Bare-Metal-Stent Implanted Distal to a Sirolimus-eluting-Stent to Treat a Long de novo Coronary Lesion2013

    • Author(s)
      Obata JE
    • Organizer
      第22回 日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Drug-eluting stent andcoronary endothelial dysfunction2012

    • Author(s)
      Jyun-ei Obata
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Residual riskとしての高レムナントリポ蛋白血症の重要性2012

    • Author(s)
      尾畑 純栄
    • Organizer
      第21回 日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Usefulness of a collateral channel dilator for antegrade treatment of chronic total occlusion of a coronary artery2012

    • Author(s)
      Obata JE
    • Organizer
      Complex Catheter Therapeutics 2012
    • Place of Presentation
      神戸国際展示場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] LMT disease2012

    • Author(s)
      Obata JE
    • Organizer
      第3回 Sendai/New Tokyo Live
    • Place of Presentation
      ヒルトン東京ベイホテル(舞浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Remnant lipoproteinemia is a risk fornon-culprit attenuated coronary plaquesdetected by grayscale intravascularultrasound in patients with acute coronarysyndromes.2011

    • Author(s)
      Jyun-ei Obata, Yoshinobu Kitta, YukioSaito, Takamitsu Nakamura, Keita Sano,Daisuke Fujioka, Juntaro Deyama, ManabuUematsu, Ken-ichi Kawabata, NaohikoTsuyuguchi, Tetsuya Asakawa, AkinoriWatanabe, Ken Umetani, Takao Sawanobori,Tsukasa Ishihara, Kiyotaka Kugiyama
    • Organizer
      米国心臓病学会
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2011-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Remnant lipoproteinemia is a risk for non-culprit attenuated coronary plaques detected by grayscale intravascular ultrasound in patients with acute coronary syndromes2011

    • Author(s)
      Obata JE, et al
    • Organizer
      American heart association scientific sessions
    • Place of Presentation
      Orange County Convention Center, Orland
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Late catch-up recoveryfrom endothelial vasomotor dysfunction ininfarct-related coronary artery treatedwith sirolimus-eluting stent in patientswith acute myocardial infarction2010

    • Author(s)
      Jyun-ei Obata, Yoshinobu Kitta,Yasushi Kodama, Yukio Saitoh, Keita Sano,Mitsumasa Hirano, Tsuyoshi Kobayashi,Toshiaki Yano, Ken-ichi Kawabata,Kiyotaka Kugiyama.
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2012 Final Research Report
  • [Presentation] High serum levels of remnant lipoprotein are associated with plaque in stability of non-culprit vessel in patients with acute coronary syndrome.2010

    • Author(s)
      Obata JE, et al.
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2010 Annual Research Report
  • [Book] 日本放射線技術学会雑誌Vol.69 No.52013

    • Author(s)
      尾畑 純栄
    • Total Pages
      9
    • Publisher
      メディカルトリビューン
    • Related Report
      2012 Annual Research Report
  • [Book] 日本放射線技術学会雑誌Vol.69 No.62013

    • Author(s)
      尾畑 純栄
    • Total Pages
      9
    • Publisher
      メディカルトリビューン
    • Related Report
      2012 Annual Research Report
  • [Book] 内科学 狭心症2012

    • Author(s)
      尾畑純栄、久木山清貴
    • Publisher
      西村書店
    • Related Report
      2012 Final Research Report
  • [Book] 循環器疾患最新の治療 2012-2013 心筋梗塞の再発予防2012

    • Author(s)
      尾畑純栄、久木山清貴
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 内科学2012

    • Author(s)
      尾畑 純栄
    • Total Pages
      5
    • Publisher
      西村書店
    • Related Report
      2012 Annual Research Report
  • [Book] 循環器疾患最新の治療2012

    • Author(s)
      尾畑純栄, 他
    • Total Pages
      4
    • Publisher
      南江堂
    • Related Report
      2011 Annual Research Report
  • [Remarks] 山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_65/B40055EA2AF208A3.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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