| Project/Area Number |
22590773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OBATA Jun-ei 山梨大学, 医学部附属病院, 講師 (60362076)
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| Co-Investigator(Kenkyū-buntansha) |
KUGIYAMA Kiyotaka 山梨大学, 大学院・医学工学総合研究部, 教授 (00225129)
WATANABE Kazuhiro 山梨大学, 医学部附属病院, 助教 (50535549)
TAKISHIMA Isao 山梨大学, 医学部附属病院, 医員 (80535534)
YANO Toshiaki 山梨大学, 医学部附属病院, 医員 (60456449)
HIRANO Mitsumasa 山梨大学, 医学部附属病院, 助教 (10436884)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 薬剤溶出性ステント / 血管内皮機能障害 / 内皮機能障害 |
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| Research Abstract |
This study aimed to examine the effect of the drug released intothe circulation from the drug-eluting stent on left ventricular functional recovery ofstunned or hibernated myocardium in multicenter collaborative investigations. As a result,(1) Study for the patients with ischemic heart disease who were treated with twooverlapping stents without a gap in the same coronary artery for a de novo lesion revealedthat the neointimal proliferation in the distal bare metal stent (BMS) was more inhibitedin patients with a sirolimus-eluting stent (SES) implanted at the proximal site comparedto those with a BMS. Sirolimus may diffuse to the vessel distal to the SES, which couldpossibly suppress the neointimal hyperplasia of the distal BMS. (2) High remnantlipoproteins levels are associated with the attenuated plaque of non-culprit vesseldetected by grayscale intravascular ultrasound in patients with acute coronary syndromes.
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