A study of inhibitory effect of drug-eluting stent on the cardiacfunctional recovery from stunned or hibernated myocardium

• Project/Area Number: 22590773
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: University of Yamanashi
• Principal Investigator: OBATA Jun-ei 山梨大学, 医学部附属病院, 講師 (60362076)
• Co-Investigator(Kenkyū-buntansha): KUGIYAMA Kiyotaka 山梨大学, 大学院・医学工学総合研究部, 教授 (00225129) ; WATANABE Kazuhiro 山梨大学, 医学部附属病院, 助教 (50535549) ; TAKISHIMA Isao 山梨大学, 医学部附属病院, 医員 (80535534) ; YANO Toshiaki 山梨大学, 医学部附属病院, 医員 (60456449) ; HIRANO Mitsumasa 山梨大学, 医学部附属病院, 助教 (10436884)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 薬剤溶出性ステント / 血管内皮機能障害 / 内皮機能障害

Research Abstract

This study aimed to examine the effect of the drug released intothe circulation from the drug-eluting stent on left ventricular functional recovery ofstunned or hibernated myocardium in multicenter collaborative investigations. As a result,(1) Study for the patients with ischemic heart disease who were treated with twooverlapping stents without a gap in the same coronary artery for a de novo lesion revealedthat the neointimal proliferation in the distal bare metal stent (BMS) was more inhibitedin patients with a sirolimus-eluting stent (SES) implanted at the proximal site comparedto those with a BMS. Sirolimus may diffuse to the vessel distal to the SES, which couldpossibly suppress the neointimal hyperplasia of the distal BMS. (2) High remnantlipoproteins levels are associated with the attenuated plaque of non-culprit vesseldetected by grayscale intravascular ultrasound in patients with acute coronary syndromes.

Research Products

• [Journal Article] In-stent restenosis is inhibited in abare metal stent implanted distal to asirolimus-eluting stent to treat a long denovo coronary lesion with small distalvessel diameter (2013)
  • Author(s): Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata KI, KugiyamaK.
  • Journal Title: Catheter CardiovascInterv
  • Peer Reviewed
• [Journal Article] Contrast-Enhanced Ultrasound Imaging of Carotid Plaque Neovascularization Is Useful for Identifying High-Risk Patients With Coronary Artery Disease. (2013)
  • Author(s): Deyama J
  • Journal Title: Circ J Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] In-Stent restenosis is inhibited in a bare metal stent implanted distal to a sirolimus-eluting stent to treat a long de novo coronary lesion with small distal vessel diameter. (2013)
  • Author(s): Obata JE
  • Journal Title: Catheter Cardiovasc Interv Volume: Epub ahead of print Issue: 6
  • DOI: 10.1002/ccd.24841
  • Peer Reviewed
• [Journal Article] Ultrasound assessment of brachial endothelial vasomotor function in addition to carotid plaque echolucency for predicting cardiovascular events in patients with coronary artery disease. (2013)
  • Author(s): Nakamura T
  • Journal Title: Int J Cardiol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Usefulness of a collateral channel dilatorfor antegrade treatment of chronic totalocclusion of a coronary artery (2012)
  • Author(s): Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata K, Kugiyama K.
  • Journal Title: J IntervCardiol Volume: Vol.25, No.6 Pages: 533-9
  • Peer Reviewed
• [Journal Article] Usefulness of a collateral channel dilator for antegrade treatment of (2012)
  • Author(s): Obata J
  • Journal Title: J Interv Cardiol. Volume: 97 Issue: 6 Pages: 533-539
  • DOI: 10.1111/j.1540-8183.2012.00758.x
  • Peer Reviewed
• [Journal Article] Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes. (2012)
  • Author(s): Hirano M
  • Journal Title: Circ J Volume: 76(6) Pages: 1452-60
  • NAID: 10030316382
  • Peer Reviewed
• [Journal Article] A comparison of the efficacy of combined ezetimibe and statin therapy with doubling of statin dose in patients with remnant lipoproteinemia on previous statin therapy. (2012)
  • Author(s): Nakamura T
  • Journal Title: J Cardiol Volume: 60(1) Issue: 1 Pages: 12-7
  • DOI: 10.1016/j.jjcc.2012.02.005
  • Peer Reviewed
• [Journal Article] Short-term progression of maximumintima-media thickness of carotid plaque is associated with future coronary eventsin patients with coronary artery disease (2011)
  • Author(s): Hirano M, Nakamura T, Kitta Y,Takishima I, Deyama J, Kobayashi T,Fujioka D, Saito Y, Watanabe K, WatanabeY, Kawabata K, Obata JE, Kugiyama K
  • Journal Title: Atherosclerosis Volume: Vol.215, No.2 Pages: 507-12
  • Peer Reviewed
• [Journal Article] Endothelialvasomotor dysfunction in the brachialartery predicts the short-termdevelopment of early stage renaldysfunction in patients with coronaryartery disease (2011)
  • Author(s): Nakamura T, Obata JE, Hirano M, KittaY, Sano K, Kobayashi T, Fujioka D, SaitoY, Yano T, Kawabata K, Watanabe K, WatanabeY, Mishina H, Kugiyama K.
  • Journal Title: Int J Cardiol Volume: Vol.148, No.2 Pages: 183-8
  • Peer Reviewed
• [Journal Article] Endothelial vasomotor dysfunction in the brachial artery predicts the short-term development of early stage renal dysfunction in patients with coronary artery disease (2011)
  • Author(s): Nakamura T, Obata JE, et al
  • Journal Title: International journal of cardiology Volume: 148(2) Pages: 183-8
  • Peer Reviewed
• [Journal Article] Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease (2011)
  • Author(s): Hirano M, Obata JE, et al
  • Journal Title: Atherosclerosis Volume: 215(2) Pages: 507-12
  • Peer Reviewed
• [Journal Article] Predictive value of serial assessment of endothelial function in chronic heart failure (2011)
  • Author(s): Takishima I, Obata JE, et al
  • Journal Title: International journal of cardiology Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Assessment ofcarotid plaque echolucency in addition toplaque size increases the predictive valueof carotid ultrasound for coronaryevents in patients with coronaryartery disease and mild carotidatherosclerosis (2010)
  • Author(s): Hirano M, Nakamura T, Kitta Y, Sano K,Kodama Y, Kobayashi T, Fujioka D, Saito Y,Yano T, Watanabe K, Watanabe Y, KawabataK, Obata JE, Kugiyama K.
  • Journal Title: Atherosclerosis Volume: Vol.211, No.2 Pages: 451-5
  • Peer Reviewed
• [Journal Article] Assessment of carotid plaque echolucency in addition to plaque size increases the predictive value of carotid ultrasound for cornary events in patients with coronary artery disease and mild carotid atherosclerosis. (2010)
  • Author(s): Hirano M, et al.
  • Journal Title: Atherosclerosis Volume: 211(2) Pages: 451-5
  • Peer Reviewed
• [Journal Article] Comparative study of bezafibrate and pravastatin in patients with coronary artery disease and high levels of remnant lipoprotein. (2010)
  • Author(s): Sano K, et al.
  • Journal Title: Circ J Volume: 74(8) Pages: 644-50
  • Peer Reviewed
• [Journal Article] High plasma levels of macrophage migration inhibitory factor are associaced with adverse long-term outcome in patients with stable coronary artery disease and impaired glucose tolerance or type 2 diabetes mellitus (2010)
  • Author(s): Makino A, et al.
  • Journal Title: Atherosclerosis Volume: 213(2) Pages: 573-8
  • Peer Reviewed
• [Presentation] Coronary endothelial vasomotor function after drug-eluting stent implantation in infarct-related coronary artery (2013)
  • Author(s): Obata JE
  • Organizer: 第22回 日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] In-stent Restenosis is Inhibited in a Bare-Metal-Stent Implanted Distal to a Sirolimus-eluting-Stent to Treat a Long de novo Coronary Lesion (2013)
  • Author(s): Obata JE
  • Organizer: 第22回 日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] Drug-eluting stent andcoronary endothelial dysfunction (2012)
  • Author(s): Jyun-ei Obata
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] Residual riskとしての高レムナントリポ蛋白血症の重要性 (2012)
  • Author(s): 尾畑 純栄
  • Organizer: 第21回 日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 朱鷺メッセ（新潟）
• [Presentation] Usefulness of a collateral channel dilator for antegrade treatment of chronic total occlusion of a coronary artery (2012)
  • Author(s): Obata JE
  • Organizer: Complex Catheter Therapeutics 2012
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] LMT disease (2012)
  • Author(s): Obata JE
  • Organizer: 第3回 Sendai/New Tokyo Live
  • Place of Presentation: ヒルトン東京ベイホテル（舞浜）
• [Presentation] Remnant lipoproteinemia is a risk fornon-culprit attenuated coronary plaquesdetected by grayscale intravascularultrasound in patients with acute coronarysyndromes. (2011)
  • Author(s): Jyun-ei Obata, Yoshinobu Kitta, YukioSaito, Takamitsu Nakamura, Keita Sano,Daisuke Fujioka, Juntaro Deyama, ManabuUematsu, Ken-ichi Kawabata, NaohikoTsuyuguchi, Tetsuya Asakawa, AkinoriWatanabe, Ken Umetani, Takao Sawanobori,Tsukasa Ishihara, Kiyotaka Kugiyama
  • Organizer: 米国心臓病学会
  • Place of Presentation: オーランド、米国
  • Year and Date: 2011-11-15
• [Presentation] Remnant lipoproteinemia is a risk for non-culprit attenuated coronary plaques detected by grayscale intravascular ultrasound in patients with acute coronary syndromes (2011)
  • Author(s): Obata JE, et al
  • Organizer: American heart association scientific sessions
  • Place of Presentation: Orange County Convention Center, Orland
  • Year and Date: 2011-11-15
• [Presentation] Late catch-up recoveryfrom endothelial vasomotor dysfunction ininfarct-related coronary artery treatedwith sirolimus-eluting stent in patientswith acute myocardial infarction (2010)
  • Author(s): Jyun-ei Obata, Yoshinobu Kitta,Yasushi Kodama, Yukio Saitoh, Keita Sano,Mitsumasa Hirano, Tsuyoshi Kobayashi,Toshiaki Yano, Ken-ichi Kawabata,Kiyotaka Kugiyama.
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] High serum levels of remnant lipoprotein are associated with plaque in stability of non-culprit vessel in patients with acute coronary syndrome. (2010)
  • Author(s): Obata JE, et al.
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Book] 日本放射線技術学会雑誌Vol.69 No.5 (2013)
  • Author(s): 尾畑 純栄
  • Total Pages: 9
  • Publisher: メディカルトリビューン
• [Book] 日本放射線技術学会雑誌Vol.69 No.6 (2013)
  • Author(s): 尾畑 純栄
  • Total Pages: 9
  • Publisher: メディカルトリビューン
• [Book] 内科学 狭心症 (2012)
  • Author(s): 尾畑純栄、久木山清貴
  • Publisher: 西村書店
• [Book] 循環器疾患最新の治療 2012-2013 心筋梗塞の再発予防 (2012)
  • Author(s): 尾畑純栄、久木山清貴
  • Publisher: 南江堂
• [Book] 内科学 (2012)
  • Author(s): 尾畑 純栄
  • Total Pages: 5
  • Publisher: 西村書店
• [Book] 循環器疾患最新の治療 (2012)
  • Author(s): 尾畑純栄, 他
  • Total Pages: 4
  • Publisher: 南江堂
• [Remarks] 山梨大学研究者総覧
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_65/B40055EA2AF208A3.html