| Project/Area Number |
22590775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Gifu University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
MINATOGUCHI Shinya 岐阜大学, 医学系研究科, 教授 (20190697)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GLP-1 / 心筋梗塞 / 左室機能障害 / 左心機能 / 心不全 / BNP / 左心駆出率 / miglitol / PI3 kinase / Akt / infarct size / voglibose / eNOS / NO / KATP channel |
|---|
| Research Abstract |
In a rabbit model of myocardial infarction with 30 min coronary ischemia and 48 hours of reperfusion, we demonstrated that oral administration of α-glucosidase inhibitors voglibose and miglitol reduced the myocardial infarct size throughproduction of plasma GLP-1, activation of PI3 kinase-Akt-NO pathway and opening of mitochondrial KATP channels. In a clinical study, we demonstrated that plasma GLP- level was significantly increased in patients with impaired cardiac function as compared with those with preserved cardiac function, and that plasma GLP-1 level was inversely correlated with left ventricular ejection fraction. These results suggest that endogenous GLP-1 is a cardioprotective agent for ischemic heart disease and left ventricular dysfunction.
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