| Project/Area Number |
22590776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SATOH Hiroshi 浜松医科大学, 医学部附属病院, 講師 (30293632)
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| Co-Investigator(Kenkyū-buntansha) |
SAOTOME Masao 浜松医科大学, 医学部附属病院, 助教 (70509512)
URUSHIDA Tsuyoshi 浜松医科大学, 医学部, 助教 (20334980)
KATOH Hideki 浜松医科大学, 医学部, 助教 (80314029)
HAYASHI Hideharu 浜松医科大学, 医学部, 教授 (50135258)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | レこンーアンジオテンシンーアルドステロン系 / レニン阻害薬 / 灌流心 / 糖尿病 / 虚血/再灌流 / ﾚﾆﾝｰｱﾝｼﾞｵﾃﾝｼﾝｰｱﾙﾄﾞｽﾃﾛﾝ系 / レニン 阻害薬 / ミトコンドリア / レニン-アンジオテンシン-アルドステロン系 |
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| Research Abstract |
We studied the intracellular expression of non-secretary renin and (pro)renin receptor after ischemia, and the effects of renin on mitochondrial membrane potential in perfused hearts from diabetic (DM) and normal rats. In DM rats, non-secretary renin expressed at mitochondria could afford protective effectsagainst ischemic damage by preventing depolarization of mitochondrial membrane potential.We also examined additive effects of direct renin inhibitor (DRI) on lipid profiles and cytokines in diabetic patients with coronary arterial disease. The additional treatment with DRI decreased plasma renin activity and blood pressure, but did not provide any beneficial effects on lipid profiles or cytokines.
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