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Individualized indication for Cardiac resynchronization therapy

Research Project

Project/Area Number 22590778
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

INDEN Yasuya  名古屋大学, 医学部附属病院, 講師 (10359747)

Co-Investigator(Kenkyū-buntansha) MUROHARA Toyoaki  名古屋大学, 医学系研究科, 教授 (90299503)
内川 智浩  名古屋大学, 医学部附属病院, 医員 (90437012)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心不全 / 心臓再同期療法 / 心エコー / ペースメーカー / 心臓再同期両方
Research Abstract

An echocardiographic index named i-Index for predicting responses to cardiac resynchronization therapy (CRT) is a newly-devised one in the post- PROSPECT study era. Receiver-operating characteristics curve analyses wereused to examine the overall discriminatory power of i-Index, and Ts lateral-septum to predict LV volume and clinical responses. LVESV decreased .15% in 58% of 106 patients at 6-month follow up. The area under the curves of i-Index for LV volumeresponses to CRT was 0.86, and these was greater than those of Ts lateral-septum for the CRT response outcomes of 0.75. And more responders were included in the opposite sided lead positioning group. We conclude that i-Index can be a complementary measure for better CRT patient selection and RV and LV leads should be implanted at opposite site around the LV for good prognosis after CRT.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (3 results) Book (4 results)

  • [Journal Article] A randomizedcontrolled trial of dabigatran versuswarfarin for periablation anticoagulationin patients undergoing ablation of atrial fibrillation2013

    • Author(s)
      Nin T, Sairaku A, Yoshida Y, Kamiya H, Tatematsu Y, Nanasato M, Inden Y, Hirayama H, Murohara T
    • Journal Title

      Pacing Clin Electrophysiol

      Volume: 36(2) Issue: 2 Pages: 172-9

    • DOI

      10.1111/pace.12036

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin,cyclophosphamide, and 5-fluorouracil inwomen with breast cancer2012

    • Author(s)
      Kitagawa K, Kawada K, Morita S, Inada M, Mitsuma A, Sawaki M, Iino S, Inden Y, Murohara T, Imai T, Ando Y
    • Journal Title

      Ann Oncol

      Volume: 23(3) Issue: 3 Pages: 743-7

    • DOI

      10.1093/annonc/mdr296

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction2011

    • Author(s)
      Hayashi M, Takeshita K, Inden Y, Ishii H, Cheng XW, Yamamoto K, Murohara T
    • Journal Title

      Thromb Res

      Volume: 128(6) Issue: 6 Pages: e113-e118

    • DOI

      10.1016/j.thromres.2011.07.013

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm2011

    • Author(s)
      Tsuji Y, 9名,(1)番目
    • Journal Title

      Circulation

      Volume: 123 Issue: 20 Pages: 2192-2203

    • DOI

      10.1161/circulationaha.110.016683

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel transitional zone index allows more accurate differentiation between idiopathic right ventricular outflow tractand aortic sinus cusp ventricular arrhythmias2011

    • Author(s)
      Yoshida N, Inden Y, Uchikawa T, Kamiya H, Kitamura K, Shimano M, Tsuji Y, Hirai M, Murohara T
    • Journal Title

      Heart Rhythm

      Volume: 8(3) Issue: 3 Pages: 349-56

    • DOI

      10.1016/j.hrthm.2010.11.023

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rate-dependent shortening of action potential duration increases ventricular vulnerability infailing rabbit heart2011

    • Author(s)
      Harada M, Tsuji Y, Ishiguro YS, Takanari H, Okuno Y, Inden Y, Honjo H, Lee JK, Murohara T, Sakuma I, Kamiya K, Kodama I
    • Journal Title

      Am J PhysiolHeart Circ Physiol

      Volume: 300(2) Issue: 2 Pages: H565-H573

    • DOI

      10.1152/ajpheart.00209.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid prevents atrial fibrillation associated with heart failure in a rabbit model2011

    • Author(s)
      Kitamura K, Shibata R, Tsuji Y, Shimano M, Inden Y, Murohara T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 300(5) Issue: 5 Pages: H1814-H1821

    • DOI

      10.1152/ajpheart.00771.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined assessment of left ventricular dyssynchrony and contractility by speckled tracking strainimaging: a novel index for predictingresponders to cardiac resynchronization therapy2010

    • Author(s)
      Inden Y, Ito R, Yoshida N, Kamiya H, Kitamura K, Kitamura T, Shimano M, Uchikawa T, Tsuji Y, Shibata R, Hirai M, Murohara T
    • Journal Title

      Heart Rhythm

      Volume: 7(5) Issue: 5 Pages: 655-61

    • DOI

      10.1016/j.hrthm.2010.01.015

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrocardiographic and electrophysiological characteristics in idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle: relevance for catheter ablation.2010

    • Author(s)
      Yamada T, Doppalapudi H, McElderry HT, Okada T, Murakami Y, Inden Y, Yoshida Y, Yoshida N, Murohara T, Epstein AE, Plumb VJ, Litovsky SH, Kay GN
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 3(4) Issue: 4 Pages: 324-331

    • DOI

      10.1161/circep.109.922310

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maximum derivative of left ventricular pressure predicts cardiac mortality after cardiac resynchronization therapy2010

    • Author(s)
      Suzuki H, Shimano M, Yoshida Y, Inden Y, Muramatsu T, Tsuji Y, Tsuboi N,Hirayama H, Shibata R, Murohara T
    • Journal Title

      Clin Cardiol

      Volume: 33(12) Issue: 12

    • DOI

      10.1002/clc.20683

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined assessment of left ventricular dyssynchrony and contractility by speckled tracking strain imaging : a novel index for predicting responders to cardiac resynchronization therapy2010

    • Author(s)
      因田恭也
    • Journal Title

      Reart Rhythm

      Volume: 7 Pages: 655-661

    • NAID

      130002130419

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 収縮非同期性に心収縮性を加味した指標により CRT responderを予測する2012

    • Author(s)
      因田恭也,他
    • Organizer
      第27回不整脈学会学術大会シンポジウム(CRTの適応を再考する)
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 収縮非同期性に心収縮性を加味した指標によりCRT responderを予測する2012

    • Author(s)
      因田恭也
    • Organizer
      第27回不整脈学会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Novel Combined Assessment of Dyssynchrony and Contractility by Strain Echocardiography Predicts Response to CRT and Ventricular2011

    • Author(s)
      因田恭也
    • Organizer
      日本循環器学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Book] 心房細動カテーテルアブレーション2013

    • Author(s)
      山根禎一、因田恭也,他
    • Total Pages
      391
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 不整脈概論-専門医になるためのエッセンシャルブック2013

    • Author(s)
      池田隆徳、山下武志、因田恭也,他
    • Total Pages
      422
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Final Research Report
  • [Book] CIRCULATION Up-to-Date(1881-3585)7巻増刊2012

    • Author(s)
      池田隆徳、因田恭也,他
    • Total Pages
      311
    • Publisher
      メディカ出版
    • Related Report
      2012 Final Research Report
  • [Book] CIRCULATION Up-to-Date(1881-3585)7巻増刊【決定版 病棟必携!カラーで診る 不整脈のアブレーション・デバイス治療マニュアル ベーシックからプロフェッショナルスキルまで】2012

    • Author(s)
      池田隆徳
    • Publisher
      メディカ出版
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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