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Evaluating the mechanisms of right ventricular remodeling after left ventricular myocardial infarction

Research Project

Project/Area Number 22590780
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionMie University

Principal Investigator

DOHI Kaoru  三重大学, 大学院・医学系研究科, 助教 (50422837)

Co-Investigator(Kenkyū-buntansha) ITO Masaaki  三重大学, 大学院・医学系研究科, 教授 (00223181)
TANABE Masaki  三重大学, 医学部附属病院, 講師 (50456737)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords臨床心血管病態学 / 心筋梗塞 / 右室 / 心エコー / ストレイン / 圧容積関係 / コンダクタンスカテーテル / リモデリング / 心筋ミオシンRLCリン酸化
Research Abstract

We evaluated the right ventricular (RV) function in dogs with left ventricular (LV) myocardial infarction (MI) generated by permanent occlusion of left coronary artery using 50μm microspheres. Ventricular contractility and relaxation were impaired, and myocardial fibrosis were prominent both in the left and right ventricles in dogs with MI (6 weeks after onset) compared with normal dogs whereas pulmonary artery pressure was similar in the both groups. These results may shed new light on the causal mechanism of RV remodeling after LVMI.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Reversible left ventricular regional non-uniformity quantified by speckle-tracking displacement and strain imaging in patients with acute pulmonary embolism

    • Author(s)
      Takamura T, Dohi K, et al
    • Journal Title

      J Am Soc Echocardiogr.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 他陳旧性心筋梗塞患者の右心室機能:左心室機能および血清BNP値との関連2012

    • Author(s)
      小西 克尚、土肥 薫、伊藤正明
    • Organizer
      第60回 日本心臓病学会学術集会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Right Ventricular Systolic Function is Highly Dependent on Left Ventricular Dysfunction in Patientswith Previous Myocardial Infarction and High Plasma Brain Natriuretic Peptide Levels2012

    • Author(s)
      小西 克尚、土肥 薫、伊藤正明
    • Organizer
      European Society of Cardiology Congress August 28 2012, Munich
    • Place of Presentation
      Germany
    • Year and Date
      2012-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Right Ventricular Systolic Function is Highly Dependent on Left Ventricular Dysfunction in Patients with Previous Myocardial Infarction and High Plasma Brain Natriuretic Peptide Levels2012

    • Author(s)
      小西 克尚(土肥 薫)
    • Organizer
      European Society of Cardiology Congress 2012
    • Place of Presentation
      Munich Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] 陳旧性心筋梗塞患者の右心室機能:左心室機能および血清BNP値との関連2012

    • Author(s)
      小西 克尚(土肥 薫)
    • Organizer
      第60回 日本心臓病学会学術集会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] Speckle-tracking Strain法を用いたMcConnell sign陽性患者の右室動態の定量的評価2010

    • Author(s)
      市川和秀, 土肥薫, 他
    • Organizer
      第58回日本心臓病学会 学術集会
    • Place of Presentation
      東京国際フォーラム(一般演題)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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