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Prediction of progression and efficacy of early treatment for asymptomatic pulmonary arterial hypertension

Research Project

Project/Area Number 22590781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionMie University

Principal Investigator

YAMADA Norikazu  三重大学, 医学部附属病院, 講師 (60303731)

Co-Investigator(Kenkyū-buntansha) ITO Masaaki  三重大学, 医学部附属病院, 教授 (00223181)
NAKAMURA Mashio  三重大学, 医学部附属病院, 講師 (40293774)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords臨床心血管病態学 / 肺高血圧症 / 運動負荷 / 薬物治療 / 早期介入 / 循環器内科 / 運動負荷試験 / 循環器
Research Abstract

In the patients who have the risks of pulmonary arterial hypertension and positive response in right heart catheterization under exercise, mean pulmonary arterial pressure had not increased to the level of pulmonary hypertension during observational period. But the abnormal responses during exercise had improved in the pharmacological intervention group compared with no intervention group. Early pharmacological intervention might be effective for patients with borderline pulmonary arterial hypertension to prevent pulmonary vascular remodeling.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 Other

All Presentation (7 results)

  • [Presentation] 肺動脈性肺高血圧症の早期診断における運動負荷下右心カテーテル検査の有用性と課題.2012

    • Author(s)
      山田典一
    • Organizer
      第1回日本肺循環学会学術集会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Abnormal response of total pulmonary resistance during exercise in patients with borderline pulmonary arterial2012

    • Author(s)
      Akimasa Matsuda, Norikazu Yamada
    • Organizer
      nternational Conference of American Thoracic Society
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Abnormal response of total pulmonary resistance during exercise in patients with borderline pulmonary arterial hypertension associated with connective tissue diseases2012

    • Author(s)
      Akimasa Matsuda, Norikazu Yamada
    • Organizer
      第76回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Abnormal response of total pulmonary resistance during exercise in2012

    • Author(s)
      Akimasa Matsuda, Norikazu Yamada
    • Organizer
      International Conference of American Thoracic Society 2012
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Early Detection and Pharmacological Intervention of Pulmonary Arterial Hypertension Associated with Connective Tissue Disease2011

    • Author(s)
      辻明宏、山田典一
    • Organizer
      第75回日本循環器学会学術総会
    • Place of Presentation
      第75回日本循環器学会学術総会
    • Year and Date
      2011-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Early Detection and Pharmacological Intervention of Pulmonary Arterial Hypertension Associated with Connective Tissue Disease2011

    • Author(s)
      辻明宏、山田典一, 他
    • Organizer
      第75回日本循環器学会学術総会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺動脈性肺高血圧症の早期診断における運動負荷下右心カテーテル検査の有用性と課題

    • Author(s)
      山田典一
    • Organizer
      第1回日本肺循環学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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