Clinical Assessment of Endothelial Dysfunction and Investigationof New Therapies in Cardiovascular Diseases

• Project/Area Number: 22590786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: SUGIYAMA Seigo 熊本大学, 大学院・生命科学研究部, 准教授 (90274711)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床心血管病態学 / 血管内皮細胞障害 / 冠動脈疾患 / 心不全 / 心血管イベント / 危険因子 / 動脈硬化 / 血管内皮機能 / 糖尿病 / vascular biology / 臨床研究 / 循環器・高血圧 / 血管内皮 / ミトコンドリア / microparticles

Research Abstract

We examined Reactive Hyperemia Peripheral Arterial Tonometry(RH-PAT) test and measurement of plasma levels of Endothelium-derived Microparticles(EMP) in patients suspected with coronary artery disease and heart failure patients inorder to assess vascular endothelial dysfunction clinically. We found CD144-EMP was anindependent prognostic factor for cardiovascular events in patients with heart failurewith reduced LVEF. We demonstrated the presence of coronary endothelial dysfunction andidentified distinctive clinical features in patients with coronary microvascular spasticangina. The vascular endothelial function assessed by RH-PAT test in patients with heartfailure with normal LVEF (HFNEF) was a significant and independent factor of the futurecardiovascular events. We demonstrated that the treatment by DPP-IV inhibitor(Sitagliptin); a new medicine for diabetes, improved the vascular endothelial functionand significantly inhibited atherosclerosis formation in the ApoE deficiency mouse, amouse model of atherosclerosis.

Research Products

• [Journal Article] Basal andischemia-induced transcardiac troponinrelease into the coronary circulationin patients with suspected coronaryartery disease (2013)
  • Author(s): Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, SakamotoK, Nagayoshi Y, Sumida H, Akiyama E,Matsuzawa Y, Sakamaki K, Morita S,Kimura K, Umemura S, Ogawa H
  • Journal Title: PLoS One Volume: 8(4) Issue: 4 Pages: e60163-e60163
  • DOI: 10.1371/journal.pone.0060163
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor,Sitagliptin, Improves EndothelialDysfunction in Association With ItsAnti-Inflammatory Effects in PatientsWith Coronary Artery Disease andUncontrolled Diabetes (2013)
  • Author(s): Matsubara J, Sugiyama S, Akiyama E,Iwashita S, Kurokawa H, Ohba K, Maeda H,Fujisue K, Yamamoto E, Kaikita K,Hokimoto S, Jinnouchi H, Ogawa H
  • Journal Title: Circ J Volume: 77 Pages: 1337-1344
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin, Improves Endothelial Dysfunction in Association With Its Anti-Inflammatory Effects in Patients With Coronary Artery Disease and Uncontrolled Diabetes (2013)
  • Author(s): Matsubara J
  • Journal Title: Circulation Journal Volume: 77 Issue: 5 Pages: 1337-1344
  • DOI: 10.1253/circj.CJ-12-1168
  • NAID: 10031151398
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease. (2012)
  • Author(s): Keisuke Ohba
  • Journal Title: J Am Heart Assoc Volume: 1 Issue: 5
  • DOI: 10.1161/jaha.112.002485
  • Peer Reviewed
• [Journal Article] Incremental prognostic significance ofperipheral endothelial dysfunction inpatients with heart failure with normalleft ventricular ejection fraction (2012)
  • Author(s): Akiyama E, Sugiyama S, Matsuzawa Y,Konishi M, Suzuki H, Nozaki T, Ohba K,Matsubara J, Maeda H, Horibata Y,Sakamoto K, Sugamura K, Yamamuro M,Sumida H, Kaikita K, Iwashita S, MatsuiK, Kimura K, Umemura S, Ogawa H
  • Journal Title: JAm Coll Cardiol Volume: 60(18) Issue: 18 Pages: 1778-86
  • DOI: 10.1016/j.jacc.2012.07.036
  • Peer Reviewed
• [Journal Article] Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease (2012)
  • Author(s): Toyama, K., Sugiyama, S., Oka, H.,Iwasaki, Y., Sumida, H., Tanaka, T., Tayama, S., Jinnouchi, H., Ogawa, H.
  • Journal Title: PLoS One Volume: 7 Issue: 7 Pages: 41369-41369
  • DOI: 10.1371/journal.pone.0041369
  • Peer Reviewed
• [Journal Article] Accumulation of pericardial fatcorrelates with left ventriculardiastolic dysfunction in patients withnormal ejection fraction (2012)
  • Author(s): Konishi M, Sugiyama S, Sugamura K,Nozaki T, Matsubara J, Akiyama E,Utsunomiya D, Matsuzawa Y, Yamashita Y,Kimura K, Umemura S, Ogawa H
  • Journal Title: J Cardiol Volume: 59(3) Issue: 3 Pages: 344-51
  • DOI: 10.1016/j.jjcc.2012.01.006
  • Peer Reviewed
• [Journal Article] A dipeptidylpeptidase-4 inhibitor,des-fluoro-sitagliptin, improvesendothelial function and reducesatherosclerotic lesion formation inapolipoprotein E-deficient mice (2012)
  • Author(s): Matsubara J, Sugiyama S, Sugamura K,Nakamura T, Fujiwara Y, Akiyama E,Kurokawa H, Nozaki T, Ohba K, Konishi M,Maeda H, Izumiya Y, Kaikita K, Sumida H,Jinnouchi H, Matsui K, Kim-Mitsuyama S,Takeya M, Ogawa H
  • Journal Title: J AmColl Cardiol Volume: 59(3) Issue: 3 Pages: 265-76
  • DOI: 10.1016/j.jacc.2011.07.053
  • Peer Reviewed
• [Journal Article] A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoproteln E-deficient mice (2012)
  • Author(s): Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H
  • Journal Title: Journal of the American College of Cardiology Volume: 59 Pages: 265-276
  • Peer Reviewed
• [Journal Article] Accumulation of pericardial fat correlates with left ventricular diastolic dysfunction in patients with normal ejection fraction (2012)
  • Author(s): Konishi M, Sugiyama S, Sugamura K, Nozaki T, Matsubara J, Akiyama E, Utsunomiya D, Matsuzawa Y, Yamashita Y, Kimura K, Umemura S, Ogawa H
  • Journal Title: Journal of Cardiology Volume: (Epub)(印刷中)
  • NAID: 10031187755
  • Peer Reviewed
• [Journal Article] Low-dose contrast protocol using the test bolus technique for 64-detector computed tomography coronary angiography (2012)
  • Author(s): Nakaura T, Awai K, Yanaga Y, Namimoto T, Utsunomiya D, Hirai T, Sugiyama S, Ogawa H, Aoyama M, Yamashita Y
  • Journal Title: Jpn J Radiol Volume: 29 Pages: 457-465
  • NAID: 50008099592
  • Peer Reviewed
• [Journal Article] Total coronaryartery plaque burden measured bycardiac computed tomography isassociated with metabolic syndrome (2011)
  • Author(s): Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, Sumida H,Nagayoshi Y, Utsunomiya D, Awai K,Yamashita Y, Matsuzawa Y, Kimura K,Umemura S, Ogawa H
  • Journal Title: JAtheroscler Thromb Volume: 18(11) Pages: 939-45
  • Peer Reviewed
• [Journal Article] Improvement effect on endothelialfunction in patients with congestiveheart failure treated with cardiacresynchronization therapy (2011)
  • Author(s): Enomoto K, Yamabe H, Toyama K, MatsuzawaY, Yamamuro M, Uemura T, Morihisa K,Iwashita S, Kaikita K, Sugiyama S, OgawaH
  • Journal Title: J Cardiol Volume: 58(1) Issue: 1 Pages: 69-73
  • DOI: 10.1016/j.jjcc.2011.01.010
  • Peer Reviewed
• [Journal Article] Rosuvastatincombined with regular exercisepreserves coenzyme Q10 levelsassociated with a significant increase in high-density lipoproteincholesterol in patients with coronaryartery disease (2011)
  • Author(s): Toyama K, Sugiyama S, Oka H, Iwasaki Y,Sumida H, Tanaka T, Tayama S, JinnouchiH, Matsui K, Ogawa H
  • Journal Title: Atherosclerosis Volume: 217(1) Issue: 1 Pages: 158-64
  • DOI: 10.1016/j.atherosclerosis.2011.02.050
  • Peer Reviewed
• [Journal Article] Pentraxin 3 isa new inflammatory marker correlatedwith left ventricular diastolicdysfunction and heart failure withnormal ejection fraction (2011)
  • Author(s): Matsubara J, Sugiyama S, Nozaki T,Sugamura K, Konishi M, Ohba K, MatsuzawaY, Akiyama E, Yamamoto E, Sakamoto K,Nagayoshi Y, Kaikita K, Sumida H,Kim-Mitsuyama S, Ogawa H
  • Journal Title: J Am CollCardiol Volume: 57(7) Issue: 7 Pages: 861-9
  • DOI: 10.1016/j.jacc.2010.10.018
  • Peer Reviewed
• [Journal Article] Total coronary artery plaque burden measured by cardiac computed tomography is associated with metabolic syndrome (2011)
  • Author(s): Konishi M, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Matsubara J, Sumida H, Nagayoshi Y, Utsunomiya D, Awai K, Yamashita Y, Matsuzawa Y, Kimura K, Umemura S, Ogawa H
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 939-945
  • NAID: 130004845344
  • Peer Reviewed
• [Journal Article] Improvement effect on endothelial function in patients with congestive heart failure treated with cardiac resynchronization therapy (2011)
  • Author(s): Enomoto K, Yamabe H, Toyama K, Matsuzawa Y, Yamamuro M, Uemura T, Morihisa K, Iwashita S, Kaikita K, Sugiyama S, Ogawa H
  • Journal Title: Journal of Cardiology Volume: 58 Pages: 69-73
  • NAID: 10031159576
  • Peer Reviewed
• [Journal Article] Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease (2011)
  • Author(s): Toyama K, Sugiyama S, Oka H, Iwasaki Y, Sumida H, Tanaka T, Tayama S, Jinnouchi H, Matsui K, Ogawa H
  • Journal Title: Atherosclerosis Volume: 217 Pages: 158-164
  • Peer Reviewed
• [Journal Article] Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. (2011)
  • Author(s): Toyama K, Sugiyama S, Oka H, Iwasaki Y, Sumida H, Tanaka T, Tayama S, Jinnouchi H, Matsui K, Ogawa H.
  • Journal Title: Atherosclerosis Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction. (2011)
  • Author(s): Matsubara J, Sugiyama S, Nozaki T, Sugamura K, Konishi M, Ohba K, Matsuzawa Y, Akiyama E, Yamamoto E, Sakamoto K, Nagayoshi Y, Kaikita K, Sumida H, Kim-Mitsuyama S, Ogawa H.
  • Journal Title: J Am Coll Cardiol Volume: 57 Pages: 861-869
  • Peer Reviewed
• [Journal Article] Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate : subanalysis from the JPAD trial. (2011)
  • Author(s): Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y ; Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes Trial Investigators.
  • Journal Title: Diabetes Care Volume: 34 Pages: 280-285
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris. (2011)
  • Author(s): Izumiya Y, Kojima S, Kojima S, Araki S, Usuku H, Matsubara J, Sakamoto K, Tsujita K, Nagayoshi Y, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: Atherosclerosis. Volume: 214 Pages: 415-421
  • Peer Reviewed
• [Journal Article] Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy. (2011)
  • Author(s): Yamamoto K, Hokimoto S, Chitose T, Morita K, Ono T, Kaikita K, Tsujita K, Abe T, Deguchi M, Miyagawa H, Saruwatari J, Sumida H, Sugiyama S, Nakagawa K, Ogawa H.
  • Journal Title: J Cardiol. Volume: 57 Pages: 194-201
  • NAID: 10031159562
  • Peer Reviewed
• [Journal Article] Hypercholesterolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque. (2011)
  • Author(s): Kojima S, Kojima S, Maruyoshi H, Nagayoshi Y, Kaikita K, Sumida H, Sugiyama S, Funahashi T, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 147 Pages: 371-376
  • Peer Reviewed
• [Journal Article] Pericardial fat inflammationcorrelates with coronary artery disease (2010)
  • Author(s): Konishi M, Sugiyama S, Sato Y, Oshima S,Sugamura K, Nozaki T, Ohba K, MatsubaraJ, Sumida H, Nagayoshi Y, Sakamoto K,Utsunomiya D, Awai K, Jinnouchi H,Matsuzawa Y, Yamashita Y, Asada Y,Kimura K, Umemura S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 213(2) Issue: 2 Pages: 649-55
  • DOI: 10.1016/j.atherosclerosis.2010.10.007
  • Peer Reviewed
• [Journal Article] Prognostic value ofendothelial microparticles in patientswith heart failure (2010)
  • Author(s): Nozaki T, Sugiyama S, Sugamura K, OhbaK, Matsuzawa Y, Konishi M, Matsubara J,Akiyama E, Sumida H, Matsui K, JinnouchiH, Ogawa H
  • Journal Title: Eur J Heart Fail Volume: 12(11) Issue: 11 Pages: 1223-8
  • DOI: 10.1093/eurjhf/hfq145
  • Peer Reviewed
• [Journal Article] Exercise therapy correlateswith improving renal function throughmodifying lipid metabolism in patientswith cardiovascular disease and chronickidney disease (2010)
  • Author(s): Toyama K, Sugiyama S, Oka H, Sumida H,Ogawa H
  • Journal Title: J Cardiol Volume: 56(2) Issue: 2 Pages: 142-6
  • DOI: 10.1016/j.jjcc.2010.06.007
  • Peer Reviewed
• [Journal Article] Digitalassessment of endothelial function andischemic heart disease in women (2010)
  • Author(s): Matsuzawa Y, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Konishi M, MatsubaraJ, Sumida H, Kaikita K, Kojima S,Nagayoshi Y, Yamamuro M, Izumiya Y,Iwashita S, Matsui K, Jinnouchi H,Kimura K, Umemura S, Ogawa H
  • Journal Title: J AmColl Cardiol Volume: 55(16) Issue: 16 Pages: 1688-96
  • DOI: 10.1016/j.jacc.2009.10.073
  • Peer Reviewed
• [Journal Article] Association of pericardial fataccumulation rather than abdominalobesity with coronary atheroscleroticplaque formation in patients withsuspected coronary artery disease (2010)
  • Author(s): Konishi M, Sugiyama S, Sugamura K、Nozaki T, Ohba K, Matsubara J, MatsuzawaY, Sumida H, Nagayoshi Y, Nakaura T,Awai K, Yamashita Y, Jinnouchi H, MatsuiK, Kimura K, Umemura S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 209(2) Issue: 2 Pages: 573-8
  • DOI: 10.1016/j.atherosclerosis.2009.10.008
  • Peer Reviewed
• [Journal Article] Pericardial fat inflammation correlates with coronary artery disease. (2010)
  • Author(s): Konishi M, Sugiyama S, Sato Y, Oshima S, Sugamura K, Nozaki T, Ohba K, Matsubara J, Sumida H, Nagayoshi Y, Sakamoto K, Utsunomiya D, Awai K, Jinnouchi H, Matsuzawa Y, Yamashita Y, Asada Y, Kimura K, Umemura S, Ogawa H.
  • Journal Title: Atherosclerosis. Volume: 213 Pages: 649-655
  • Peer Reviewed
• [Journal Article] Impact of statin pretreatment on the incidence of plaque rupture in ST-elevation acute myocardial infarction. (2010)
  • Author(s): Otsuka F, Hibi K, Kusama I, Endo M, Kosuge M, Iwahashi N, Okuda J, Tsukahara K, Ebina T, Kojima S, Sugiyama S, Ogawa H, Umemura S, Kimura K.
  • Journal Title: Atherosclerosis Volume: 213 Pages: 505-511
  • Peer Reviewed
• [Journal Article] Prognostic value of endothelial microparticles in patients with heart failure. (2010)
  • Author(s): Nozaki T, Sugiyama S, Sugamura K, Ohba K, Matsuzawa Y, Konishi M, Matsubara J, Akiyama E, Sumida H, Matsui K, Jinnouchi H, Ogawa H.
  • Journal Title: Eur J Heart Fail. Volume: 12 Pages: 1223-1228
  • Peer Reviewed
• [Journal Article] Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease. (2010)
  • Author(s): Toyama K, Sugiyama S, Oka H, Sumida H, Ogawa H.
  • Journal Title: J Cardiol. Volume: 56 Pages: 142-146
  • NAID: 10027704010
  • Peer Reviewed
• [Journal Article] Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis. (2010)
  • Author(s): Maruyoshi H, Kojima S, Kojima S, Nagayoshi Y, Horibata Y, Kaikita K, Sugiyama S, Ogawa H.
  • Journal Title: Circ J. Volume: 74 Pages: 1251-1256
  • NAID: 10026475144
  • Peer Reviewed
• [Journal Article] Digital assessment of endothelial function and ischemic heart disease in women. (2010)
  • Author(s): Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemurn S, Ogawa H.
  • Journal Title: J Am Coll Cardiol. Volume: 74 Pages: 1251-1256
  • Peer Reviewed
• [Journal Article] Association of pericardial fat accumulation rather than abdominal obesity with coronary atherosclerotic plaque formation in patients with suspected coronary artery disease. (2010)
  • Author(s): Konishi M, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Matsubara J, Matsuzawa Y, Sumida H, Nagayoshi Y, Nakaura T, Awai K, Yamashita Y, Jinnouchi H, Matsui K, Kimura K, Umemura S, Ogawa H.
  • Journal Title: Atherosclerosis. Volume: 209 Pages: 573-578
  • Peer Reviewed
• [Presentation] How to Reduce Residual Riskin Patients with DM in the Statin Era? (2013)
  • Author(s): 杉山 正悟
  • Organizer: 第77回日本循環器学会学術集会(招待講演)
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2013-03-19
• [Presentation] ラウンドテーブルディスカッション：How to Reduce Residual Risk i Patients withDM in the Statin Era? (2013)
  • Author(s): 杉山 正悟
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Invited
• [Presentation] 血管内皮機能検査から全身を診る 「血管内皮機能検査による心血管リスクの評価の実際と臨床応用 (2012)
  • Author(s): 杉山 正悟
  • Organizer: 第60回日本心臓病学会学術集会 (招待講演)
  • Place of Presentation: ホテル日航金沢、金沢市
  • Year and Date: 2012-09-16
• [Presentation] 血管病変の非侵襲的評価法の有用性 (2012)
  • Author(s): 杉山 正悟
  • Organizer: 第60回日本心臓病学会学術集会 (招待講演)
  • Place of Presentation: ホテル日航金沢、 金沢市
  • Year and Date: 2012-09-14
• [Presentation] Incremental Significance of Endothelial Function Assessed by Reactive Hyperemia Peripheral Arterial Tonometry for Predicting Cardiovascular Events in stable Patients With Coronary Artery Disease (2012)
  • Author(s): Matsuzawa Y, Sugiyama S, Akiyatna E, Umemura S, Kimura K, Ogawa H
  • Organizer: American College of Cardiology 2012
  • Place of Presentation: Chicago McCormick Place
  • Year and Date: 2012-03-26
• [Presentation] <シンポジウム>Heart Failure with Preserved Ejection Fraction Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction (2012)
  • Author(s): Akiyama E, Ohba K, Sugiyama S, Konishi M, Nozaki T, Matsubara J, Sumida H, Matsui K, Kimura K, Umemura S, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡国際会議場
  • Year and Date: 2012-03-18
• [Presentation] Asian Joint Case-Conference 10 : Thailand and Japan Effects of Immediate Statin-therapy on Left Ventricular Remodeling and Functions after STelevated Myocardial Infarction Treated by Coronary Stenting (2012)
  • Author(s): Seigo Sugiyama, Tadasuke Chitose, Hideki Shimomura, Takuro Yamashita,Jun Hokamaki, Ryusuke Tsunoda, Hisao Ogawa
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡国際会議場(招待講演)
  • Year and Date: 2012-03-18
• [Presentation] Clinical Significance and Characteristic of Coronary Microvascular Spasm in Non-Obstructive Coronary Artery Disease (2012)
  • Author(s): Ohba K, Sugiyama S, Matsubara J, Maeda H, Kurokawa H, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡国際会議場
  • Year and Date: 2012-03-18
• [Presentation] 拡張不全と炎症 (2012)
  • Author(s): 杉山 正悟
  • Organizer: 第76回日本循環器学会学術集会(招待講演)
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2012-03-17
• [Presentation] <シンポジウム>冠狭窄病変のない狭心症へのアプローチComprehensive Diagnostic Approach to Non-obstructive Coronary Artery Disease by Using Coronary Doppler FloWire and EndoPAT2000-Role of Endothelial Dysfunction- (2012)
  • Author(s): Sugiyama S, Matsuzawa Y, Ohba K, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡マリンメッセ福岡
  • Year and Date: 2012-03-17
• [Presentation] <シンポジウム>心血管リスク評価におけるイメージングと生理機能検査の意義Incremental Significance of Endothelial Function Assessed by Peripheral Arterial Tonometry for Predicting Cardiovascular Events in Patients with Coronary Artery Disease (2012)
  • Author(s): Matsuzawa Y, Sugiyama S, Sumida H, Nozaki T, Sugamura K, Matsubara J, Ohba K, Konishi M, Akiyama E, Suzuki H, Iwashita S, Matsui K, Kimura K, Umemura S, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡サンパレス
  • Year and Date: 2012-03-17
• [Presentation] モーニングレクチャー:拡張不全と炎症Inflammation and Endothelial Dysfunction in Heart Failure Patients with Preserved Left Ventricular Ejection Fraction (HFpEF) (2012)
  • Author(s): Seigo Sugiyama, Junichi Matsubara, Eiichi Akiyama, Yasushi Matsuzawa, Kazuo Kimura, Hisao Ogawa
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡国際会議場(招待講演)
  • Year and Date: 2012-03-17
• [Presentation] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improved Endothelial Function through Enhancing Action of Glucagon-like Peptide-1 in Vivo and in Vitro (2012)
  • Author(s): Matsubara J, Sugiyama S, Nakamura T, Kurokawa H, Iwashita S, Ohba K, Maeda H, Jinnouchi H, Kim- Mitsuyama S, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡国際センター
  • Year and Date: 2012-03-16
• [Presentation] Beneficial Myocardial Effects of Immediate Rosuvastatin-therapy on Left Ventricular Remodeling and Functions after ST-elevated Myocardial Infarction Treated by Coronary Stenting (2012)
  • Author(s): Chitose T, Sugiyama S, Shimomura H, Yamashita T, Hokamaki J, Tsunoda R, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡マリンメッセ福岡
  • Year and Date: 2012-03-16
• [Presentation] Decreased Plasma Levels of Active Glucagon-Like Peptide-1 Correlate with Coronary Artery Disease and Coronary Plaque Complexity in High-risk Patients (2012)
  • Author(s): Akiyama E, Sugiyama S, Konishi M, Ohba K, Nozaki T, Matsubara J, Sumida H, Kimura K, Umemura S, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡マリンメッセ福岡
  • Year and Date: 2012-03-16
• [Presentation] Combined Treatment with Dipeptidyl-Peptidase-4 Inhibitor and Glucagon-like Peptide-1 Attenuated Endothelium Inflammation through Activation of AMP-activated Protein Kinase/Endothelial-Nitric Oxide Synthase Pathway (2012)
  • Author(s): Kurokawa H, Sugiyama S, Matsubara J, Ohba K, Maeda H, Ogawa H
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡福岡サンパレス
  • Year and Date: 2012-03-16
• [Presentation] Advanced Endothelial Dysfunction in Patients with Coexistence of Coronary Artery Disease and Peripheral Artery Disease -Effect of Cilostazol on the Advanced Endothelial Dysfunction- (2012)
  • Author(s): Hirofumi Maeda
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Disturbance in Cardiac Th1/th2 Cytokine Balance Plays the Pivotal Role in the Transition from Left Ventricular Hypertrophy to Diastolic Heart Failure In Salt-Sensitive Hypertensive Rats (2012)
  • Author(s): Hiroaki Kusaka
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Higher Red Blood Cell Distribution Width Predicts Cardiovascular Events in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction (2012)
  • Author(s): Eiichi Akiyama
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Decreased Levels of Endogenous Plasma Active Glucagon Like Peptide-1 were Correlated with Endothelial Dysfunction in Patients with Coronary Risk Factors (2012)
  • Author(s): Junichi Matsubara
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Prognostic Value of Serum Sodium Concentrations for Cardiovascular Events in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction (2012)
  • Author(s): Hiroaki Kusaka
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Impact of Endothelial Dysfunction on Residual Platelet Aggregability after Dual Antiplatelet Therapy with Aspirin and Clopidogrel in Stable Patients with Coronary Artery Disease (2012)
  • Author(s): Koichiro Fujisue
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Combined Treatment with Dipeptidyl-Peptidase-4 Inhibitor and Glucagon-Like Peptidase-1 Attenuates Endothelial Inflammation through Activation of AMP-Activated Protein Kinase/Endothelial-Nitric Oxidase Synthase Pathway (2012)
  • Author(s): Hirofumi Kurokawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Lower Framingham Risk Score and Less Calcium Channel Blocker Use are Associated with Morning Peak in the Circadian Variation of Acute Coronary Syndrome Onset (2012)
  • Author(s): Hiroki Usuku
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Basal and Ischemia-Induced Transcardiac Troponin Release into the Coronary Circulation in Patients with Suspected Coronary Artery Disease (2012)
  • Author(s): Masaaki Konishi
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Decreased Postprandial Active Glucagon-Like Peptide-1 Levels Correlate with Coronary Spastic Angina (2012)
  • Author(s): Eiichi Akiyama
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Association of Peripheral Endothelial Function and Coronary Artery Disease in Patients with Chronic Kidney disease (2012)
  • Author(s): Yoshihiro Hirata
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Pentraxin 3 is a Significant Inflammatory Maker Predicting Future Cardiovascular Events in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction (2012)
  • Author(s): Junichi Matsubara
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Incremental Significance of Endothelial Function Assessed by Reactive Hyperemia Peripheral Arterial Tonometry to Improve Risk Stratification in High Risk Patients for Cardiovascular Events (2012)
  • Author(s): Yasushi Matsuzawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Association of Reactive Oxygen Metabolites and High-sensitivity CRP with severity of angiographic Coronary Artery Disease (2012)
  • Author(s): Yoshihiro Hirata
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] 教育講演-17：血管内皮機能検査から全身を診る「血管内皮機能検査による心血管リスクの評価の実際と臨床応用」 (2012)
  • Author(s): 杉山 正悟
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航金沢、金沢市
  • Invited
• [Presentation] パネルディスカッション：血管病変の非侵襲的評価法の有用性 (2012)
  • Author(s): 杉山 正悟
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 石川県立音楽堂、金沢市
  • Invited
• [Presentation] <シンポジウム>Cardiovascular Risk Stratification of by Endothelium-Derived Microparticles (2011)
  • Author(s): Sugiyama S, Nozaki T, Koga H, Ogawa H
  • Organizer: The 19^<th> Annual Meeting of the Japanese Vascular Biology and Medicine Organization/The 1^<st> Asia-Pacific Vascular Biology Meeting
  • Place of Presentation: 東京Tokyo Station Conference(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Incremental Prognostic Significance of Peripheral Endothelial Dysfunction for Cardiovascular Events in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction (2011)
  • Author(s): Akiyama E, Sugiyama S, Matsuzawa Y, Konishi M, Nozaki T, Ohba K, Matsubara J, Sugamura K, Sumida H, Kaikita K, Iwashita S, Matsui K, Kimura K, Umemura S, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-16
• [Presentation] Peripheral Endothelial Dysfunction is a Significant Determinant of Contrast-Induced Renal Damage in Patients Underwent Percutaneous Coronary Procedures (2011)
  • Author(s): Sumida H, Matsuzawa Y, Sugiyama S, Akiyama E, Iwashita S, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-15
• [Presentation] Utility of Digital Assessment of Endothelial Function for Cardiovascular Risk Stratification in Patients with Diabetes Mellitus (2011)
  • Author(s): Matsuzawa Y, Sugiyama S, Hitoshi S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Akiyama E, Iwashita S, Matsui K, Umemura S, Kimura K, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-15
• [Presentation] Decreased Plasma Levels of Active Glucagon-Like Peptide-1 Correlate With Coronary Artery Disease and Coronary Plaque Complexity in High-Risk Patients (2011)
  • Author(s): Akiyama E, Sugiyama S, Matsuzawa Y, Konishi M, Nozaki T, Ohba K, Matsubara J, Sumida H, Kaikita K, Kimura K, Umemura S, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-15
• [Presentation] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improved Endothelial Function through Enhancing Action of Glucagon-Like Peptide-1 in vivo and in vitro (2011)
  • Author(s): Matsubara J, Sugiyama S, Nakamura T, Kurokawa H, Ohba K, Maeda H, Shokei Kim-Mitsuyama, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-14
• [Presentation] Beneficial Myocardial Effects of Immediate Rosuvastatin-Therapy on Left Ventricular Functions after ST-Elevated Myocardial Infarction (2011)
  • Author(s): Chitose T, Sugiyama S, Shimomura H, Yamashita T, Hokamaki J, Tsunoda R, Shiraishi S, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-14
• [Presentation] Digital Assessment of Peripheral Endothelial Function for the Risk Stratification in Patients With Hypertension (2011)
  • Author(s): Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Akiyama E, Iwashita S, Matsui K, Umemura S, Kimura K, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-13
• [Presentation] Increased Oxidative Stress in Heart Failure With Normal Left Ventricular Ejection Fraction (2011)
  • Author(s): Akiyama E, Sugiyama S, Matsuzawa Y, Konishi M, Nozaki T, Ohba K, Matsubara J, Sumida H, Kaikita K, Kimura K, Umemura S, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida Orange County Convention Center
  • Year and Date: 2011-11-13
• [Presentation] 新しい炎症マーカーである Pentraxin3 と拡張障害 (2011)
  • Author(s): 杉山 正悟
  • Organizer: 拡張障害性心不全との関係 第15回日本心不全学会学術集会(招待講演)
  • Place of Presentation: 鹿児島 かごしま県民交流センター
  • Year and Date: 2011-10-13
• [Presentation] <シンポジウム>新しい炎症マーカーであるPentraxin3と拡張障害、拡張障害性心不全との関係 (2011)
  • Author(s): 杉山正悟、松原純一、小川久雄
  • Organizer: 第15回日本心不全学会学術集会
  • Place of Presentation: 鹿児島かごしま県民交流センター(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] Endothelial Dysfunction is a Significant Determinant Factor of Contrast-Induced Renal Dysfunction in Patients with Early stage of Chronic Kidney Disease<プレナリーセッション> (2011)
  • Author(s): Sumida H, Sugiyama S, Matsuzawa Y, Nozaki T, Akiyama E, Matsubara J, Tsujita K, Kaikita K, Ohba K, Konishi M, Yamamuro M, Izumiya Y, Kojima S, Hokimoto S, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] <シンポジウム>心臓CTとMRIの最前線Cardiac Computed Tomography Assessment of Pericardial Fat Associated with Coronary Atherosclerosis and Left Ventricular Diastolic Dysfunction (2011)
  • Author(s): Konishi M, Sugiyama S, Nozaki T, Ohba K, Akiyama E, Sakamoto K, Sumida H, Kimura K, Umemura S, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Increased Levels of Average Peak Velocity of Coronary Flow at Baseline Condition Associates with Non-obstructive Coronary Artery Disease (2011)
  • Author(s): Ohba K, Sugiyama S, Sumida H, Nozaki T, Akiyama E, Matsubara J, Ono T, Yamamoto K, Morihisa K, Yamamoto Y, Tsujita K, Nagayoshi Y, Yamamuro M, Izumiya Y, Kojima S, Kaikita K, Hokimoto S, Tayama S, Koyama J, Yamabe H, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Increased Oxidative stress in Heart Failure with Normal Left Ventricular Ejection Fraction (2011)
  • Author(s): Akiyama E, Sugiyama S, Konishi M, Ohba K, Nozaki T, Matsubara J, Sumida H, Kimura K, Umemura s, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Decreased Plasma Levels of Glucagon-Like Peptide-1 Associate with Coronary Artery Disease in High Risk Patients (2011)
  • Author(s): Akiyama E, Sugiyama S, Konishi M, Ohba K, Nozaki T, Matsubara J, Sumida H, Kimura K, Umemura S, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Digital Assessment of Endothelial Dysfunction in Patients with Coexistence of Coronary Artery Disease and Peripheral Arterial Disease-Effects of Cilostazol- (2011)
  • Author(s): Maeda H, Matsuzawa Y, Sumida H, Sugiyama S, Ogawa H, Jinnouchi H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Utility of Digital Assessment of Endothelial Function for Cardiovascular Risk Stratification in Patients with Diabetes Mellitus (2011)
  • Author(s): Matsuzawa Y, Sugiyama S, Kimura K, Umemura S, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Dipeptidyl Peptidase-4 Inhibitor Improved Endothelial Function and Reduced Atherosclerotic Lesion Formation in Apolipoprotein E-deficient Mice (2011)
  • Author(s): Matsubara J, Sugiyama S, Sugamura K, Nozaki T, Nakamura T, Ohba K, Akiyama E, Maeda F, Izumiya Y, Kaikita K, Sumida H, Shokei Kim-Mitsuyama, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] Decreased Diastolic to Systolic Velocity Ratio of Basal Coronary Artery Flow Associates with Coronary Microvascular Spasm in Normal Coronary Angiography (2011)
  • Author(s): Ohba K, Sugiyama S, Sumida H, Nozaki T, Akiyama E, Matsubara J, Ono T, Yamamoto K, Morihisa K, Yamamoto E, Tsujita K, Nagayoshi Y, Yamamuro M, Izumiya Y, Kojima S, Kaikita K, Hokimoto S, Tayama S, Koyama J, Yamabe H, Ogawa H
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] 冠動脈疾患患者におけるRosuvastatin服用下の長期運動は、CoenzymeQ10をさげることなくHDL-Cを有意にに上昇する (2011)
  • Author(s): 外山研介, 杉山正悟, 岡秀樹, 濱田真理, 里田亜矢子, 小川久雄
  • Organizer: 第17回心臓リハビリテーション学会学術集会YIA
  • Place of Presentation: 大阪大阪国際会議場(YIA優秀賞を受賞)
  • Year and Date: 2011-07-16
• [Presentation] Rosuvastatin服用下の長期運動は、冠動脈疾患患者の血中CoenzymeQ10を維持したままHDL-Cを増加させる (2011)
  • Author(s): 外山研介, 杉山正悟, 岡秀樹, 角田等, 田中朋子, 田山信至, 陣内秀昭, 小川久雄
  • Organizer: 第110回日本循環器学会九州地方会:YIA
  • Place of Presentation: 福岡アクロス福岡(YIA最優秀賞を受賞)
  • Year and Date: 2011-06-25
• [Presentation] ガス分子による血管内皮機能調節～血管内皮機能測定の意義と問題点 (2011)
  • Author(s): 杉山 正悟
  • Organizer: 第11回日本NO学会学術集会(招待講演)
  • Place of Presentation: 東京 昭和薬科大学
  • Year and Date: 2011-05-14
• [Presentation] <シンポジウム>ガス分子による血管内皮機能調節～血管内皮機能測定の意義と問題点～血管内皮機能と心血管リスク (2011)
  • Author(s): 杉山正悟、松澤泰志、秋山英一、小川久雄
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: 東京昭和薬科大学(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin (DFS), Improved Endothelial Function and Reduced Atherosclerotic Lesion Formation in Apolipoprotein E-deficient Mice (2010)
  • Author(s): J Matsubara, S Sugiyama, K Sugamura, T Nozaki, T Nakamura, K Ohba, E Akiyama, H Maeda, Y Izumiya, K Kaikita, H Sumida, S Kim-Mitsuyama, H Ogawa.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-17
• [Presentation] Accumulation of Pericardiol Fat Correlates with Diastolic Dysfunction in Patients with Preserved Ejection Fraction (2010)
  • Author(s): M Konishi, S Sugiyama, Y Matsuzawa, K Kimura, H Ogawa
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-17
• [Presentation] Diastolic to Systolic Velocity Ratio of Coronary Artery Flow at Basal Condition Indicates Coronary Microvessel Spasm in Normal Coronary Angiography. (2010)
  • Author(s): K Ohba, S Sugiyama, T Nozaki, E Akiyama, J Matsubara, H Maeda, H Sumida, S Takashio, H Kanazawa, T Chitose, K Enomoto, T Ono, K Yamamoto, E Yamamoto, T Tanaka, K Morihisa, K Tsujita, Y Nagayoshi, Y Izumiya, M Yamamuro, S Kojima, S Tayama, K Kaikita, S Hokimoto, H Yamabe, H Ogawa.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-17
• [Presentation] Efficacy of Low-dose Aspirin Therapy for Primary Prevention of Ath erosclerotic Events Depends on the Severity of Diabetes : a sub-analysis of JPAD trial. (2010)
  • Author(s): S Okada, T Morimoto, H Ogawa, M Nakayama, M Sakuma, S Uemura, M Kanauchi, N Doi, H Jinnouchi, H Soejima, S Sugiyama, M Waki, T Kawano, Y Saito
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-17
• [Presentation] Telmisartan Enhances Mitochondrial Biogenesis and Protects Endothelial Cells from Oxidative Injury Through AMP-Activated Protein Kinase. (2010)
  • Author(s): T Nozaki, S Sugiyama, K Sugamura, K Ohba, J Matsubara, E Akiyama, H Sumida, H Ogawa.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-16
• [Presentation] Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease (2010)
  • Author(s): K Kaikita, T Ono, S Hokimoto, K Tsujita, Y Miyazaki, K Sato, E Horio, H Sumida, S Sugiyama, H Ogawa.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-16
• [Presentation] Impact of Blood Pressure Control in Type 2 Diabetes Patients in Relation to Aspirin Therapy : Insight From the JPAD Trial. (2010)
  • Author(s): H Soejima, M Nakayama, T Morimoto, M Sakuma, S Uemura, M Kanauchi, N Doi, H Jinnouchi, S Sugiyama, M Waki, S Okada, T Kawano, Y Saito, H Ogawa
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-15
• [Presentation] Angiopoietin-Like Protein2 (angptl2) Promotes Coronary Endothelial Dysfunction and Atherosclerosis (2010)
  • Author(s): E Horio, K Kaikita, M Tabata, T Zhe, H Tazume, K Miyata, Y Miyazaki, T Ono, K Sato, K Tsujita, S Hokimoto, H Sumida, S Sugiyama, H Ogawa, Y Oike
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: McCORMICK PLACCE Chicago, Illinois, USA
  • Year and Date: 2010-11-15
• [Presentation] 非心臓血管手術周術期の心血管イベントおける病攣縮の影響 (2010)
  • Author(s): 永吉靖央, 角田等, 杉山正悟, 黒田豊, 海北幸一, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-19
• [Presentation] たこつぼ型心筋症におけるST上昇と合併症の関係 (2010)
  • Author(s): 高潮征爾, 山室恵, 森久健二, 辻田賢一, 海北幸一, 掃本誠治, 角田等, 杉山正悟, 中尾浩一
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-19
• [Presentation] 持発性収縮性心膜炎に対して、ステロイド投与が著効した一例 (2010)
  • Author(s): 平田快絋, 森久健二, 坂本憲治, 辻田賢一, 海北幸一, 角田等, 杉山正悟, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-19
• [Presentation] 拡張不全型心不全患者において酸化ストレスは進している-尿中8-hydroxy-2'-deoxyguanosine(8-OHdG)での検討 (2010)
  • Author(s): 秋山英一, 杉山正悟, 岩下さとみ, 木村一雄, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-18
• [Presentation] 冠動脈疾患患者におけるチトクロームP4502C19遺伝子多型がクロピドグレルの血小板反応に与える影響 (2010)
  • Author(s): 山本浩一郎, 掃本誠治, 小野敬道, 辻田賢一, 海北幸一, 角田等, 杉山正悟, 中川和子
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-18
• [Presentation] 急性心筋梗塞患者における血清Flt3-Ligand濃度と末梢血樹状細胞数の減少 (2010)
  • Author(s): 福嶋隆一郎, 副島弘文, 福永崇, 杉山正悟, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-18
• [Presentation] 待機的経皮的冠動脈インターベンション後の血中好感度トロポニンT濃度の上昇と寄与因子に関する検討 (2010)
  • Author(s): 小野敬道, 海北幸一, 佐藤幸治, 堀尾英治, 千年忠祐, 宮崎勇次, 辻田賢一, 坂本憲治, 田山信至, 掃本誠治, 角田等, 杉山正悟, 山部浩茂, 小川久雄
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム:東京
  • Year and Date: 2010-09-17