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Optical imaging studies of the generation of atrial arrythmia evoked by abnormal automatism

Research Project

Project/Area Number 22590787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SAKAI Tetsuro  琉球大学, 医学研究科, 教授 (40153845)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光イメージング / 膜電位感受性色素 / 心房 / 不整脈 / カオス / event-to-event variations / カルシウムイオン / event-to-event variation / CCDカメラ / ブレビスタチン
Research Abstract

Using optical imaging methods together with voltage-sensitive dye, we analyzed spatio-temporal patterns of excitation spread during the tachycardia-like excitation evoked by electrical stimulation in the isolated rat atrium. Event-to-event variations, which seem to result from physiologically trivial difference(s) of the initial conditions,were always observed among the excitation spread patterns. Based on these results, we consider that tachycardia-like excitation is an example of a spatio-temporal chaos in the physiological system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Optical mapping study of blebbistatin-induced chaotic electrical activities in isolated rat atrium preparation2010

    • Author(s)
      Kanlop N, Sakai T
    • Journal Title

      J Physiol Sci

      Volume: 60 Pages: 109-117

    • NAID

      10027711480

    • Related Report
      2012 Final Research Report
  • [Journal Article] Optical mapping study of blebbistatin-induced chaotic electrical activities in isolated rat atrium preparation2010

    • Author(s)
      N.Kanlop, T.Sakai
    • Journal Title

      Journal of Physiological Sciences

      Volume: 60 Pages: 109-117

    • NAID

      10027711480

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 摘出心房標本の頻拍様興奮における時空カオス発現の光学的イメージング解析2013

    • Author(s)
      酒井哲郎
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of photodiode array and CCD camera as the photodetector for multiple-site optical recording using an absorption dye in the isolated rat atrium2012

    • Author(s)
      酒井哲郎
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本市松本文化会館
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chaotic electrical excitation in the rat atrium revealed by optical mapping studies2012

    • Author(s)
      T. SakaiKamino K
    • Organizer
      The 4th Internatinal Interdisciplinary Symposium on Chaos and Complex Systems
    • Place of Presentation
      Antalya,Turkey
    • Related Report
      2012 Final Research Report
  • [Presentation] 摘出心房標本における吸光変化による膜電位光学測定の光センサーとしてのフォトダイオードアレイとCCDカメラの比較2012

    • Author(s)
      酒井哲郎
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Presentation] 摘出心房標本における細胞内Ca2+過負荷時に見られた興奮旋回の光学的解析2011

    • Author(s)
      酒井哲郎
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 摘出心房標本におけるブレビスタチン誘発性異常心電活動の光学的解析2010

    • Author(s)
      酒井哲郎、Kanlop N
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Chaotic electrical excitation in the rat atrium revealed by optical mapping studies

    • Author(s)
      酒井哲郎
    • Organizer
      The 4th International Interdisciplinary Symposium on Chaos and Complex Systems
    • Place of Presentation
      WOW Topcapi Palace Hotel Antalya (トルコ共和国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 摘出心房標本の頻拍様興奮における時空カオス発現の光学的イメージング解析

    • Author(s)
      酒井哲郎
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール堀船(東京都)
    • Related Report
      2012 Annual Research Report
  • [Book] Chaotic electrical excitation in the rat atrium revealed by optical mapping studies In Chaos and Complex Systems ed2013

    • Author(s)
      Sakai Tand Kamino K by Stavros G et al.
    • Related Report
      2012 Final Research Report
  • [Book] Chaos and Complex Systems ed. by Stavros G. et al. (分担執筆)2013

    • Author(s)
      Sakai T.
    • Total Pages
      581
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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