Optical imaging studies of the generation of atrial arrythmia evoked by abnormal automatism
Project/Area Number |
22590787
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | University of the Ryukyus |
Principal Investigator |
SAKAI Tetsuro 琉球大学, 医学研究科, 教授 (40153845)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 光イメージング / 膜電位感受性色素 / 心房 / 不整脈 / カオス / event-to-event variations / カルシウムイオン / event-to-event variation / CCDカメラ / ブレビスタチン |
Research Abstract |
Using optical imaging methods together with voltage-sensitive dye, we analyzed spatio-temporal patterns of excitation spread during the tachycardia-like excitation evoked by electrical stimulation in the isolated rat atrium. Event-to-event variations, which seem to result from physiologically trivial difference(s) of the initial conditions,were always observed among the excitation spread patterns. Based on these results, we consider that tachycardia-like excitation is an example of a spatio-temporal chaos in the physiological system.
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Report
(4 results)
Research Products
(12 results)