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Cohort study for verifying the heart rate lowering therapy for the prevention of cardiovascular event in diabetic patients with coronary artery disease

Research Project

Project/Area Number 22590788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of the Ryukyus

Principal Investigator

INOUE Taku  琉球大学, 医学部附属病院, 助教 (00537102)

Co-Investigator(Kenkyū-buntansha) UEDA Shinichiro  琉球大学, 医学研究科, 教授 (80285105)
Co-Investigator(Renkei-kenkyūsha) OHYA Yusuke  琉球大学, 医学部, 教授 (30240964)
KATSUMATA Yuriko  琉球大学, 医学部附属病院, 特命助教 (00437998)
UEDA Ikuko  慶応大学, 医学部, 助教 (80571398)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心拍数 / 冠動脈疾患 / 予後 / 安定冠動脈疾患 / β遮断薬 / 糖尿病 / 交感神経 / 二次予防
Research Abstract

For evaluating the validity of heart rate lowering therapy in coronary artery disease patients, we conducted a prospective cohort study of diabetic patients with stable coronary artery disease. A total of 1591patients were followed for a mean duration of 3.2 years and evaluated the relationship between in-treatment resting heart rate and subsequent cardiovascular events. As the result, elevated in-treatment heart rate was an independent predictor of cardiovascular event.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2013 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (16 results)

  • [Journal Article] Heart rate as a possible therapeutic guide for the prevention of cardiovascular disease2013

    • Author(s)
      Inoue T, Ohya Y, Iseki K
    • Journal Title

      Hypertens Res

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation between increased heart rate and subclinical inflammation in subjects without apparent cardiovascular disease2012

    • Author(s)
      Inoue T, Iseki K, Iseki C et al
    • Journal Title

      Angiology

      Volume: 63 Pages: 541-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heart rate as an independent prognostic factor for mortality in Japanese hemodialysis patients2012

    • Author(s)
      Inoue T, Tokuyama K, Yoshi S, Iseki K, Iseki C
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 938-944

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧と交感神経2012

    • Author(s)
      井上卓, 大屋祐輔
    • Journal Title

      CARDIAC PRACTICE

      Volume: 23 Pages: 169-174

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Heart rate as an independent prognostic factor for mortality in Japanese hemodialysis patients.2012

    • Author(s)
      Inoue T
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 6 Pages: 938-944

    • DOI

      10.1007/s10157-012-0641-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated heart rate, a risk factor and risk marker of cardiovascular disease2011

    • Author(s)
      Inoue T, Ohya Y
    • Journal Title

      Curr Hypertens

      Volume: 7 Pages: 29-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管老化とバイオマーカー2011

    • Author(s)
      井上卓, 植田真一郎
    • Journal Title

      Anti-aging Science

      Volume: 3 Pages: 65-69

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] β遮断薬の使用上の注意点2011

    • Author(s)
      井上卓, 大屋祐輔
    • Journal Title

      月刊循環器

      Volume: 1 Pages: 72-79

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Relation between increased heart rate and subclinical inflammation in subjects without apparent cardiovascular disease2011

    • Author(s)
      Inoue T, Iseki K, Iseki C, Kinjo K
    • Journal Title

      Angiology

      Volume: 63 Issue: 7 Pages: 541-546

    • DOI

      10.1177/0003319711428071

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated heart rate, a risk factor and risk marker of cardiovascular disease2011

    • Author(s)
      Inoue T, Ohya Y
    • Journal Title

      Current Hypertension Review

      Volume: 7 Issue: 1 Pages: 29-40

    • DOI

      10.2174/157340211795909034

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 脈拍数とメタボリック症候群2010

    • Author(s)
      井上卓, 大屋祐輔
    • Journal Title

      血圧 2010

      Volume: 16 Pages: 1039-1037

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prehypertensionの代謝的特長2010

    • Author(s)
      井上卓, 大屋祐輔
    • Journal Title

      血圧 2010

      Volume: 17 Pages: 280-282

    • Related Report
      2012 Final Research Report
  • [Journal Article] 他科処方薬と降圧薬との相互作用2010

    • Author(s)
      井上卓, 植田真一郎
    • Journal Title

      血圧 2010

      Volume: 17 Pages: 784-788

    • Related Report
      2012 Final Research Report
  • [Presentation] Heart rate predicts developing proteinuria in subjects with pre-diabetes and diabetes mellitus2013

    • Author(s)
      Inoue T, Nagahama K, Ohya Y
    • Organizer
      77回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Prognostic significance of statin use for coronary artery disease patientswho achieved the guideline recommended LDL-C level2013

    • Author(s)
      Arasaki O, Inoue T, Ueda Se t al
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Heart rate predicts developing proteinuria in subjects with pre-diabetes and diabetes mellitus2013

    • Author(s)
      Inoue T
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prognostic significance of statin use for coronary artery disease patientswho achieved the guideline recommended LDL-C level2013

    • Author(s)
      Arasaki O
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hyperuricemia and the risk for diabetes mellitus in a Japanese community: A 4-year follow-up study in a large population-based cohort2013

    • Author(s)
      長浜一史
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高血圧合併冠動脈疾患患者における、心拍数と慢性腎臓病の予後に及ぼす影響2012

    • Author(s)
      井上卓,大屋祐輔,植田真一郎
    • Organizer
      第35回日本高血圧学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 経過中の心拍数レベルは、糖尿病合併安定冠動脈疾患患者の全死亡および心血管疾患発症に関連する2012

    • Author(s)
      井上卓,植田真一郎ら
    • Organizer
      第60回日本心臓病学会
    • Place of Presentation
      金沢
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 経過中のLDL-Cレベルではなく、スタチンの使用が糖尿病合併安定冠動脈疾患患者のイベント発症に関連する2012

    • Author(s)
      新崎修,井上卓,植田真一郎
    • Organizer
      第60回日本心臓病学会
    • Place of Presentation
      金沢
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] The impact of elevated heart rate and chronic kidney disease on all-cause death and cardiovascular events in coronary artery disease patients with type II diabetes2012

    • Author(s)
      Inoue T, Ueda S
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      Munch Germany
    • Year and Date
      2012-08-29
    • Related Report
      2012 Final Research Report
  • [Presentation] The impact of elevated heart rate and chronic kidney disease on all-cause death and cardiovascular events in coronary artery disease patients with type II diabetes2012

    • Author(s)
      Inoue T
    • Organizer
      European Society of Cardiology Congress 2012
    • Place of Presentation
      Munich, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新崎修ら 糖尿病合併冠動脈疾患患者における血圧レベルと予後2011

    • Author(s)
      宇都宮 井上卓,植田真一郎
    • Organizer
      第34回日本高血圧学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病合併冠動脈疾患患者における予後予測因子としての心拍数の意義2011

    • Author(s)
      井上卓,植田真一郎ら
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病合併冠動脈疾患患者における予後予測因子としての心拍数の意義2011

    • Author(s)
      井上卓、新崎修、梶原光嗣、新里譲、石川直樹、大屋祐輔、植田真一郎
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elevated Resting Heart Rate Is an Independent Predictor of All Cause Death and Cardiovascular Event in Japanese Ambulatory Hemodyalysis Patients2011

    • Author(s)
      Inoue T, Tokuyama K
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Elevated Resting Heart Rate Is an Independent Predictor of All Cause Death and Cardiovascular Event in Japanese Ambulatory Hemodyalysis Patients2011

    • Author(s)
      Inoue T, Tokuyama K, Yoshi S, Nagayoshi N, Iseki C, Iseki K
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心拍数は心血管疾患を有さない対象者において不顕性炎症と関連する2010

    • Author(s)
      井上卓、井関邦敏、井関千穂、金城幸善
    • Organizer
      第58回日本心臓病学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-19
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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