Development of spectroscopy using next generation frequency-domain optical coherence tomography and assessment of the treatment of vulnerable plaque by this newly developed technique.
| Project/Area Number |
22590791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Takashi 和歌山県立医科大学, 医学部, 助教 (90438284)
MURAGAKI Yasumitsu 和歌山県立医科大学, 医学部, 教授 (40190904)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 臨床心血管病態学 / 光干渉断層法 / スペクトロスコピー / 不安定プラーク / 動脈硬化 / optical coherence tomography / thin-cap fibroatheroma (TCFA) / 急性冠症候群 / 脂質低下療法 / thin-cap fibroatheroma(TCFA) |
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| Research Abstract |
Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences has been developed anddescribed in a literature, and it is now applicable for three-dimensional reconstruction of coronary artery images in newly developed frequency-domain OCT system, althoughspectroscopic analysis system of coronary plaques are still under -developing at the moment. Identification of vulnerable plaques by characteristics of gray-scale OCT images have been reported in many literatures, and further investigation using spectroscopic analysis would be performed in the near future after completely developing the spectroscopy analysis in newly developed frequency-domain OCT system.
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Report
(4 results)
Research Products
(263 results)
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[Journal Article] Thin-cap fibroatheroma as high risk plaque for microvascular obstruction in patients with acute coronary syndrome2011
Author(s)
Ozaki Y, Tanaka A, Tanimoto T, Kitabata H, Kashiwagi M, Kubo T, Takarada S, Ishibashi K, Komukai K, Ino Y, Hirata K, Mizukoshi M, Imanishi T, Akasaka T
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Journal Title
Circ Cardiovasc Imag
Volume: 4(6)
Pages: 620-627
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[Journal Article] Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic angina2011
Author(s)
Tanaka A, Shimada K, Tearney G. J, Kitabata H, Taguchi H, Fukuda S, Kashiwagi M, Kubo T, Takarada S, Hirata K, Mizukoshi M, Yoshikawa J,Bouma B.E, Akasaka T
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Journal Title
J Am Coll Cardiol
Volume: 58(15)
Pages: 1608-1613
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[Journal Article] Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion2010
Author(s)
Takarada S, Imanishi T, Liu Y, Ikejima H, Tsujioka H, Kuroi A, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Kitabata H, Kubo T, Nakamura N, Hirata K, Tanaka A, Mizukoshi M, Akasaka T
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Journal Title
Catheter Cardiovasc Interv
Volume: 75(2)
Pages: 202-206
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[Journal Article] Clinical classification and plaque morphology determined by optical coherence tomography in unstable angina pectoris2010
Author(s)
Mizukoshi M, Imanishi T, Tanaka A, Kubo T, Liu Y, Takarada S, Kitabata H, Tanimoto T, Komukai K, Ishibashi K, Akasaka T
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Journal Title
Am J Cadiol
Volume: 106(3)
Pages: 323-328
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[Journal Article] The effect of lipid and inflammatory profiles on the morphological changes of lipid-rich plaques in patients with non-STsegment elevated acute coronary syndrome: follow-up study by optical coherence tomography and intravascular ultrasound2010
Author(s)
Takarada S, Imanishi T, Ishibashi K, Tanimoto T, Komukai K, Ino Y, Kitabata H, Kubo T, Tanaka A, Kimura K, Mizukoshi M, Akasaka T
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Journal Title
J Am Coll Cardiol Interv
Volume: 3(7)
Pages: 766-772
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[Presentation] Effect of intensive vs. moderate lipidlowering therapy with atorvastatin on the stabilization of atherosclerosis in acute coronary syndromes - serial optical coherence tomography analysis2012
Author(s)
Akasaka T, Komukai K, Ishibashi K, Tanimoto T, Matsuo Y, Ino Y, Kitabata H, Kubo T, Tanaka A,Imanishi T
Organizer
European Society of Cardiology 2012
Place of Presentation
Munich, German
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[Presentation] The Relationship between the plaque morphology of culprit lesions and clinical presentations of ACS patients2010
Author(s)
Ino Y, Kitabata H, Kubo T, Tanaka A, Komukai K, Tanimoto T, Ishibashi K, Masuno T, Takarada S, Shimokado A, Kuroi A, Hirata K, Kimura K, MizukoshiM, Imanishi T, Akasaka T
Organizer
an optical coherence tomography study. American College of Cardiology 59th Annual Scientific Session
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] Clinical presentation and plaque morphology in unstable angina pectoris: an optical coherence tomography study2010
Author(s)
Mizukoshi M, Kubo T, Tanaka A, Takarada S, Kitabata H, Tanimoto T, Kuroi A, Ikejima H, Komukai K, Ino Y, Tsujioka H, Okochi K, Kashiwagi M, Ozaki Y, Shimokado A, Hirata K, Imanishi T, Akasaka T
Organizer
American College of Cardiology 59thAnnual Scientific Session
Place of Presentation
Atlanta, USA
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