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Development of software system for next-generation multi-channel high amplification and high resolution ECG and clinical application

Research Project

Project/Area Number 22590792
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionIwate Medical University

Principal Investigator

NAKAI Kenji  岩手医科大学, 歯学部, 教授 (90146035)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心電図 / 致死的不整脈 / 再分極 / 心室細動 / Tp-e dispersion / 心室遅延電位 / 心房細動 / 遠隔医療 / T波交互脈 / 最大エントロピー法 / スペクトル解析 / 心臓再同期療法 / T-wave current alternans / 心房細動波 / 大震災 / 高分解能心電計 / QT延長 / 突然死
Research Abstract

We developed next -generation multi-channel high amplification and high resolution ECG. Our concept consisted
1. an analysis of repolarization phenomenon of myocardium (Tp-e dispersion, T-wave current alternans) for evaluating life -threatening arrhythmia
2. spectrum analysis for evaluating atrial fibrillation wave and substrate nature of ventricular late potential. We verified the clinical usefulness of n ext-generationmulti-functional solution ECG for clinical utility .
In addition, based on the experience of huge tsunami and earthquake of 3.11, we developed prototype high resolution multi-functional ECG for rem ote medical care or disaster.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011 2010 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (20 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Detection of peropartum myocardial burden by vector-projected 187 channel electrocardiography and serum NT-proBNP2013

    • Author(s)
      Terada M, Nakai K, Fukushima A, et al.
    • Journal Title

      Int Heart J

      Volume: 54 Pages: 140-145

    • Related Report
      2012 Final Research Report
  • [Journal Article] Interlead difference between T-peak to T-end intervals in resynchronization patients with an implantable cardioverter-defibrillator.2012

    • Author(s)
      Suzuki A, Shiga T, Nakai K, et al.
    • Journal Title

      Jelectrocardio

      Volume: 4 Pages: 706-712

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Body surface Two-dimensional spectral map of atrial fibrillation using vector-projected 187 channel electrocardiography2012

    • Author(s)
      Nakai K, Itoh M, Okabayashi H, et al.
    • Journal Title

      Int heart J

      Volume: 53 Pages: 5-10

    • NAID

      130001917170

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial distribution of ventricular late potentials assessed by the newly developed signal-averaged vector-projected 187-channel electrocardiogram in patients with old myocardial infarction.2012

    • Author(s)
      Futagawa K, Shoda M, Nakai K , Hiroshi Kasanuki H, Hagiwara N.
    • Journal Title

      J Arrhythmia

      Volume: 29 Pages: 28-33

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Body surface Two-dimensional spectral map of atrial fibrillation using vector-projected 187 channel electrocardiography.2012

    • Author(s)
      Nakai K, Itoh M, Okabayashi H, et al.
    • Journal Title

      Int Heart J

      Volume: 53 Pages: 5-10

    • NAID

      130001917170

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial distribution of ventricular late potentials assessed by the newly developed signal-averaged vector-projected 187-channel electrocardiogram in patients with old myocardial infarction2012

    • Author(s)
      Futagawa K, Shoda M, Nakai K, et al.
    • Journal Title

      J Arrhythmia

      Volume: 29 Issue: 1 Pages: 28-33

    • DOI

      10.1016/j.joa.2012.09.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel algorithm for identifying T-wave current density alternans using synthesized 187 -channel vector-projected body surface mapping.2011

    • Author(s)
      Nakai K, Takahashi S, Suzuki A, et al.
    • Journal Title

      Heart vessels

      Volume: 26 Pages: 160-167

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Combined CYP2C9 and VKORC1 Genotypes in Japanese Patients Requiring Warfarin2011

    • Author(s)
      Miyagata Y, Nakai K, T Sugiyama.
    • Journal Title

      Int Heart J

      Volume: 52 Pages: 1-6

    • NAID

      130000410639

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel algorithm for identifying T-wave current density alternans using synthesized 187-channel vector-projected body surface mapping2011

    • Author(s)
      Nakai K, et al
    • Journal Title

      Heart vessels

      Volume: 26 Pages: 160-167

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Combined CYP2C9 and VKORC1 Genotypes in Japanese Patients Requiring Warfarin2011

    • Author(s)
      Miyagata Y, Nakai K, et al
    • Journal Title

      Int Heart J

      Volume: 52 Pages: 44-49

    • NAID

      130000410639

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of fetal autonomic nervous system activity by fetal magnetocardiography : Comparison of normal pregnancy and intrauterine growth restriction2011

    • Author(s)
      Akimune Fukushima, Kenji Nakai, Tomonobu Kanasugi, et al
    • Journal Title

      Journal of Pregnancy

      Volume: 2011 Pages: 1-6

    • DOI

      10.1155/2011/218162

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel algorithm for identifying T-wave current density alternans using synthesized 187-channel vector-projected body surface mapping.2011

    • Author(s)
      Nakai K, Takahashi S, Suzuki A, et al.
    • Journal Title

      Heart Vessels

      Volume: 26 Pages: 160-167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Combined CYP2C9 and VKORC1 Genotypes in Japanese Patients Requiring Warfarin.2011

    • Author(s)
      Miyagata Y, Nakai K, T Sugiyama.
    • Journal Title

      Int Heart J

      Volume: 52 Pages: 44-49

    • NAID

      130000410639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal diagnosis of polymorphic ventricular tachycardia using 64-channel magnetocardiography2010

    • Author(s)
      Fukushima A, Nakai K, et al.
    • Journal Title

      Heart Vessels

      Volume: 25 Pages: 270-273

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interlead difference between T-peak to T-end intervals in resynchronization patients with an implantable cardioverter-defibrillator.2010

    • Author(s)
      Suzuki A, Shiga T, Nakai K, et al.
    • Journal Title

      J Electrocardiol

      Volume: 43 Pages: 706-712

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Spectral Map of Atrial Fibrillation and Atrial flutter by a DREAM-ECG compared with 64 Channel Magnetocardiogram.2013

    • Author(s)
      Nakai K , Tsuboi J, Mitsunaga Y, Okabayashi H.
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] New algorithm for a characterization of high -frequency signals and two-dimensional dominant frequency map by 187ch signal-averaged vector-projection ECG.2013

    • Author(s)
      Nakai K, Suzuki A, Shiga T, ほか
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Spectral Map of Atrial Fibrillation and Atrial flutter by a DREAM-ECG compared with 64 Channel Magnetocardiogram2013

    • Author(s)
      Nakai K, Tsuboi J, Mitsunaga Y, Okabayashi H
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] New algorithm for a characterization of high-frequency signals and two-dimensional dominant frequency map by 187ch signal-averaged vector-projection ECG2013

    • Author(s)
      Nakai K , Suzuki A, Shiga T, et al.
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] DREAM-ECGによる心室脱分極・再分極二次元機能図の開発と心室細動例のリスク評価2012

    • Author(s)
      中居賢司、佐藤嘉洋、椚田房紀、ほか。
    • Organizer
      第27回日本不整脈学会
    • Place of Presentation
      千葉
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Risk Stratification of Electrical Storm in Patients Receiving Cardiac Resynchronization Therapy With a Defibrillator by Signal-Averaged Synthesized 187ch Electrocardiography2012

    • Author(s)
      Nakai K, Suzuki A, Shiga T, et al.
    • Organizer
      5th APHRS
    • Place of Presentation
      Taipei
    • Year and Date
      2012-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Risk Stratification of Electrical Storm in Patients Receiving Cardiac Resynchronization Therapy With a Defibrillator by Signal-Averaged Synthesized 187ch Electrocardiography2012

    • Author(s)
      Nakai K, Suzuki A, Shiga T, et al.
    • Organizer
      5th Asian Pacific Heart Rhythm Society
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベクトル合成187ch高分解能心電図計による心臓再同期療法患者における electrical stormのリスク評価2012

    • Author(s)
      中居賢司、伊藤学、鈴木敦、ほか
    • Organizer
      第29回日本心電学会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Risk Stratification of Ventricular Fibrillation by Two-dimensional Functional Image of Repolarization Dispersion and T-wave Alternance Using Synthesized 187-channel ECG2011

    • Author(s)
      Taipei
    • Organizer
      4th APHRS
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Two-Dimensional Body Surface Dominant Frequency by Vector-Projected 187 -channel Electrocardiography May Evaluate a Characteristics of Atrial Fibrillation2011

    • Author(s)
      Nakai K, Itoh M, Tsuboi J, Mitsunaga Y, et al.
    • Organizer
      4th APHRS
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Risk Stratification of Ventricular Fibrillation by Two-dimensional Functional Image of Repolarization Dispersion and T-wave Alternance Using Synthesized 187-channel ECG2011

    • Author(s)
      Nakai K, et al
    • Organizer
      4th Asian Pacific Heart Rhythm Society (APHRS)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two-Dimensional Body Surface Dominant Frequency by Vector-Projected 187-channel Electrocardiography May Evaluate a Characteristics of Atrial Fibrillation2011

    • Author(s)
      Nakai K, et al
    • Organizer
      4th Asian Pacific Heart Rhythm Society (APHRS)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Verification of Spacial Distribution of High-Frequency Potential of 187-ch Signal-Averaged Vector - Projected Electrocardiogram by 45-ch Body Surface Mapping and 64-ch Magnetocardiography.2011

    • Author(s)
      Nakai K, Itoh M, Komatsu T, et al.
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Verification of Spacial Distribution of High-Frequency Potential of 187-ch Signal-Averaged Vector-Projected Electrocardiogram by 45-ch Body Surface Mapping and 64-ch Magnetocardiography2011

    • Author(s)
      Nakai K, et al
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ベクトル合成187チャネル心電計による心室の脱分極と再分極の二次元機能図解析の開発と心室細動例での意義2011

    • Author(s)
      中居賢司, ほか
    • Organizer
      第31回日本ホルター・ノンインベイシブ心電学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 64チャネル心磁計による心房細動波の解析と臨床的意義2011

    • Author(s)
      中居賢司、伊藤学、坪井潤二, 他
    • Organizer
      21回体表心臓微小電位研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Three-dimensional Myocardial Injury & Spectral Map of Atrial Fibrillation by a 64 Channel Magnetocardiogram2010

    • Author(s)
      Nakai K, Tsuboi J, Okabayashi H, et al.
    • Organizer
      The 3rd Asian Pacific Symposium of Magneto-cardiogram (3rd ASMCG)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベクトル合成187チャネルによる心室再分極指標の評価-64チャネル心磁図および45チャネル体表面心電図との対比2010

    • Author(s)
      中居賢司、佐藤嘉洋、小松隆, 他
    • Organizer
      第27回日本心電学会
    • Place of Presentation
      大分
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Three-dimensional Spectral Map of Atrial Fibrillation by a 64 Channel Magnetocardiogram2010

    • Author(s)
      Nakai K, Tsuboi J, Okabayashi H, et al.
    • Organizer
      The 29th International Congress on High-Speed Imaging and Photonics (29th ICHSIP)
    • Place of Presentation
      Morioka
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel Algorithm for Identifying T-wave Current Density Alternans Using Synthesized 187-Channel Vector-Projected Body Surface Mapping2010

    • Author(s)
      Nakai K, Takahashi A, Hagiwara N, et al.
    • Organizer
      第25回日本不整脈学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Book] 心磁計および多チャンネル心電計、不整脈学(監修 井上 博、村川祐二)2012

    • Author(s)
      中居賢司
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 不整脈学, 心磁計および多チャンネル心電計2012

    • Author(s)
      中居賢司
    • Total Pages
      5
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] ベクトル合成187チャネル加算心電図による致死的不整脈の評価。不整脈ノンインベイシブ検査(監修 田邉晃久)、2010

    • Author(s)
      中居賢司
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.iwate-med.ac.jp/education/gakubu_in/dent_kouza/sikanaika/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.iwate-med.ac.jp/gakubu_in/dent/sikanaika.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 心電図解析装置2012

    • Inventor(s)
      中居賢司、伊藤学、ほか2名
    • Industrial Property Rights Holder
      フクダ電子(株)、岩手医科大学、(株)アイシーエス
    • Industrial Property Number
      2006-147362
    • Filing Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 心電図解析装置2012

    • Inventor(s)
      中居賢司、伊藤学
    • Industrial Property Rights Holder
      中居賢司、伊藤学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-04-06
    • Acquisition Date
      2012-11-30
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 電流密度分布による心房細動波スペクトルとT波交互脈の二次元機能図解析アルゴリズムの発明2008

    • Inventor(s)
      中居賢司、伊藤学
    • Industrial Property Rights Holder
      岩手医科大学
    • Filing Date
      2008
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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