| Project/Area Number |
22590794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
INOUE Teruo 獨協医科大学, 医学部, 教授 (20168454)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Shichiro 獨協医科大学, 医学部, 教授 (80275718)
TAGUCHI Isao 獨協医科大学, 医学部, 准教授 (80316570)
SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199)
NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199)
NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 臨床心血管病態学 / 分子血管病態学 |
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| Research Abstract |
In this study, we investigated wound healing process after stent-induced vascular injury in the second generation drug-eluting stent (DES) such as zotarolimus-eluting stent (ZES) and everolimus-eluting stent (EES) and compared with bare metal stent (BMS) or the first generation DES. The BMS induced mobilization of endothelial progenitor cells (EPCs) that leads to re-endothelialization in the injured vessel wall. However, ZES as well as EES substantially inhibited the EPC mobilization and re-endothelialization, possibly leading to relapse and prolongation of inflammatory reaction at late phase. even second generation DESs remain problematic in terms of the wound healing process after vascular injury.
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