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Wound healing response in injured vessel wall after implantationof drug-eluting stents

Research Project

Project/Area Number 22590794
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionDokkyo Medical University

Principal Investigator

INOUE Teruo  獨協医科大学, 医学部, 教授 (20168454)

Co-Investigator(Kenkyū-buntansha) ABE Shichiro  獨協医科大学, 医学部, 教授 (80275718)
TAGUCHI Isao  獨協医科大学, 医学部, 准教授 (80316570)
SAKUMA Masashi  佐賀大学, 医学部, 医員 (10530199)
NODE Koichi  佐賀大学, 医学部, 教授 (80359950)
Co-Investigator(Renkei-kenkyūsha) SAKUMA Masashi  佐賀大学, 医学部, 医員 (10530199)
NODE Koichi  佐賀大学, 医学部, 教授 (80359950)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords臨床心血管病態学 / 分子血管病態学
Research Abstract

In this study, we investigated wound healing process after stent-induced vascular injury in the second generation drug-eluting stent (DES) such as zotarolimus-eluting stent (ZES) and everolimus-eluting stent (EES) and compared with bare metal stent (BMS) or the first generation DES. The BMS induced mobilization of endothelial progenitor cells (EPCs) that leads to re-endothelialization in the injured vessel wall. However, ZES as well as EES substantially inhibited the EPC mobilization and re-endothelialization, possibly leading to relapse and prolongation of inflammatory reaction at late phase. even second generation DESs remain problematic in terms of the wound healing process after vascular injury.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (19 results) (of which Invited: 1 results)

  • [Journal Article] Late phase inflammatory response as a feature of in-stent restenosis after drug-eluting stent implantation2013

    • Author(s)
      Yoneda S, Abe S, Kanaya T, Oda K, Nishino S, Kageyama M, Taguchi I, Masawa N, Inoue T
    • Journal Title

      Coron Artery Dis

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclophilin A is a promising predictor of coronary artery disease.2013

    • Author(s)
      Taguchi I, Abe S, Inoue T
    • Journal Title

      Circ J

      Volume: 77 Pages: 321-322

    • NAID

      10031138906

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of serial changes in tissue characteristics during statin-induced plaque regression using virtual histology-intravascular ultrasound studies.2013

    • Author(s)
      Taguchi I, Oda K, Yoneda S, Kageyama M, Kanaya T, Toyoda S, Abe S, Node K, Inoue T
    • Journal Title

      Am J Cardiol

      Volume: 111 Issue: 9 Pages: 1246-1252

    • DOI

      10.1016/j.amjcard.2013.01.265

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension.2013

    • Author(s)
      Taguchi I, Toyoda S, Takano K, Arikawa T, Kikuchi M, Ogawa M, Abe S, Node K, Inoue T
    • Journal Title

      Hypertens Res

      Volume: in press Issue: 7 Pages: 608-613

    • DOI

      10.1038/hr.2013.3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late phase inflammatory response as a feature of in-stent restenosis after drug-eluting stent implantation.2013

    • Author(s)
      Yoneda S, Abe S, Kanaya T, Oda K, Nishino S, Kageyama M, Taguchi I, Masawa N, Inoue T
    • Journal Title

      Coron Artery Dis

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The late phase inflammatory response after drug-eluting stent implantation.2013

    • Author(s)
      Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T
    • Journal Title

      Heart Vessels

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of in-stent restenosis after sirolimus-eluting stent vs. bare metal stent placement2012

    • Author(s)
      Abe S, Yoneda S, Kanaya T, Oda K, Nishino S, Kageyama M, Taguchi I, Masawa N, Inoue T
    • Journal Title

      Cardiovasc Pathol

      Volume: 21 Issue: 2 Pages: 19-22

    • DOI

      10.1016/j.carpath.2011.02.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammation and impaired wound healing after zotarolimus-eluting stent implantation2012

    • Author(s)
      Yoneda S, Abe S, Taguchi I, Masawa N, Inoue K, Inoue T
    • Journal Title

      Cardiovasc Pathol

      Volume: 21 Issue: 6 Pages: 511-514

    • DOI

      10.1016/j.carpath.2012.01.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular inflammation and repair: implication for reendothelialization, restenosis, and stent thrombosis.2011

    • Author(s)
      Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI
    • Journal Title

      J Am Coll Cardiol Intv

      Volume: 4 Issue: 10 Pages: 1057-1066

    • DOI

      10.1016/j.jcin.2011.05.025

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stent Thrombosis After Drug Eluting Stent Implantation2011

    • Author(s)
      Taguchi I, Abe S, Inoue T
    • Journal Title

      Circulation Journal

      Volume: 75 Issue: 6 Pages: 1316-1317

    • DOI

      10.1253/circj.CJ-11-0407

    • NAID

      10028148431

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of matrix metalloproteinase-9 is associated with mobilization of bone marrow-derived cells after coronary stent implantation2011

    • Author(s)
      Inoue T, Taguchi I, Abe S, et al
    • Journal Title

      Int J Cardiol

      Volume: 152 Pages: 332-336

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of in-stent restenosis after sirolimus-eluting stent vs.bare metal stent placement2011

    • Author(s)
      Abe S, Yoneda S, Kanaya T, et al
    • Journal Title

      Cardiovasc Pathol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfatides are associated with neointimal thiclosing after vascular injury.2010

    • Author(s)
      Inoue T, Taguchi I, Abe S, et al
    • Journal Title

      Atherosclerosis

      Volume: 211 Pages: 291-296

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of matrix metalloproteinase-9 is associated with mobilization of bone marrow-derived cells after coronary stent implantation.2010

    • Author(s)
      Inoue T, Taguchi I, Abe S, et al
    • Journal Title

      Int J Cardiol

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The late phase inflammatory response after drug-eluting stent implantation

    • Author(s)
      Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T
    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23649933

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Serial change in tissue characteristics during flaque regression process by statins-virtual histology intravascular ultrasound evaluation2012

    • Author(s)
      Taguchi I, Inoue T
    • Organizer
      Japanese Circulation Society 2012 KSC-JCS Joint Symposium
    • Place of Presentation
      Fukuoka, Japan(招待講演)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impairment of reendothelialization and delayed inflammatory response after drug-eluting stent implantation2012

    • Author(s)
      Inoue T
    • Organizer
      第76回日本循環器学会学術集会Topic
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inflammation in coronary artery disease2012

    • Author(s)
      Inoue T
    • Organizer
      第76回日本循環器学会学術集会Morning Lecture
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inflammatory response at late phase after drug-eluting stent implantation2012

    • Author(s)
      Yoneda S, Oda K, Nasuno T, Nishino S, Kageyama M, Tokura M, Taguchi I, Abe S, Inoue T
    • Organizer
      Japanese Circulation Society 2012
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Restenotic tissue assessment by qualitative optical coherence tomography2012

    • Author(s)
      Yoneda S, Oda K, Nasuno T, Nishino s, Kageyama M, Tokura M, Taguchi I, Abe s, Inoue T
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impaired would healing response and late inflammatory relapse after drug-eluting stent implantation2012

    • Author(s)
      Inoue T
    • Organizer
      Japanese Circulation Society 2012 Featured Research Session Key Note Lecture
    • Place of Presentation
      Fukuoka, Japan(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Delayed inflammatory response after drug-eluting stent implantation2012

    • Author(s)
      Abe S, Taguchi I, Inoue T
    • Organizer
      第76回日本循環器学会学術集会Symposium
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of neointimal coverage over the stent struts by optical coherence tomography2012

    • Author(s)
      Yoneda S, Oda K, Nasuno T, Nishino S, Kageyama M, Tokura M, Taguchi I, Abe S, Inoue T
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serial change in tissue characteristics during plaque regression process by statins-virtual histology intravascular ultrasound evaluation-2011

    • Author(s)
      Taguchi I, Oda K, Toi T, Kageyama M, Toyoda S, Abe S, Node K, Inoue T
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Matrix metalloproteinase-9 might contribute to mobilization of bone marrow-derived cells after coronary stent implantation2011

    • Author(s)
      Taguchi I, Inoue T, Abe S, Kikuchi M, Toyoda S, Arikawa T, Sakuma M, Node K
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Delayed inflammatory response as a feature of in-stent restenosis after drug-eluting stent implantation2010

    • Author(s)
      Yoneda S, Abe S, Kanaya T, et al
    • Organizer
      American Heart Association 2010
    • Place of Presentation
      Chicago
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inflammation in vascular injury and repair after stenting -novel issues in DES era and our approach to the 'stentless' PCI-.

    • Author(s)
      Inoue T
    • Organizer
      NSE up-to-date ~the stentless coronary angioplasty~
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Stentless balloon angioplasty with a novel balloon catheter,lacrosse non-slip element balloon

    • Author(s)
      Kageyama M, Taguchi I, Tokura M, Nishiyama Y, Nasuno T, Nishino S, Yoneda S, Oda K, Abe S, Inoue T
    • Organizer
      The 21th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics
    • Place of Presentation
      Niigata, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inflammatory response at late phase after drug-eluting stent implantation

    • Author(s)
      Yoneda S, Oda K, Nasuno T, Nishino S, Kageyama M, Tokura M, Taguchi I, Abe S, Inoue T
    • Organizer
      The 21th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics
    • Place of Presentation
      Niigata, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Matrix metalloproteinase-9 might contribute to mobilization of bone marrow-derived cells after coronary stent implantation.

    • Author(s)
      Nasuno T, Taguchi I, Kikuchi M, Toyoda S, Abe S, Node K, Inoue T
    • Organizer
      19th Asia Pacific Congress of Cardiology
    • Place of Presentation
      Pattya, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sulfatides are associated with neointimal thickning after vascular injury.

    • Author(s)
      Nasuno T, Taguchi I, Kageyama M, Toyoda S, Kikuchi M, Abe S, Kyogeshima M, Node K, Inoue T
    • Organizer
      19th Asia Pacific Congress of Cardiology
    • Place of Presentation
      Pattya, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Serial change in tissue chatacteristics during plaque regression process by statins-virtual histology intravascular ultrasound evaluation.

    • Author(s)
      Kageyama M, Taguchi I, Kikuchi M, Toyoda S, Abe S, Node K, Inoue T
    • Organizer
      19th Asia Pacific Congress of Cardiology
    • Place of Presentation
      Pattya, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stentless coronary angioplasty using non slip elements balloon is acceptable strategy in selected patients.

    • Author(s)
      Kageyama M, Taguchi I, Oda K, Kikuchi M, Toyoda S, Abe S, Node K, Inoue T
    • Organizer
      19th Asia Pacific Congress of Cardiology
    • Place of Presentation
      Pattya, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Catheter-based observation of blood nitric oxide levels in forearm artery.

    • Author(s)
      Abe S, Tokura M, Nishiyama Y, Kageyama M, Nishino S, Nasuno T, Taguchi I, Inoue T
    • Organizer
      The 77th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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