Wound healing response in injured vessel wall after implantationof drug-eluting stents
Project/Area Number |
22590794
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Dokkyo Medical University |
Principal Investigator |
INOUE Teruo 獨協医科大学, 医学部, 教授 (20168454)
|
Co-Investigator(Kenkyū-buntansha) |
ABE Shichiro 獨協医科大学, 医学部, 教授 (80275718)
TAGUCHI Isao 獨協医科大学, 医学部, 准教授 (80316570)
SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199)
NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
|
Co-Investigator(Renkei-kenkyūsha) |
SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199)
NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 臨床心血管病態学 / 分子血管病態学 |
Research Abstract |
In this study, we investigated wound healing process after stent-induced vascular injury in the second generation drug-eluting stent (DES) such as zotarolimus-eluting stent (ZES) and everolimus-eluting stent (EES) and compared with bare metal stent (BMS) or the first generation DES. The BMS induced mobilization of endothelial progenitor cells (EPCs) that leads to re-endothelialization in the injured vessel wall. However, ZES as well as EES substantially inhibited the EPC mobilization and re-endothelialization, possibly leading to relapse and prolongation of inflammatory reaction at late phase. even second generation DESs remain problematic in terms of the wound healing process after vascular injury.
|
Report
(4 results)
Research Products
(34 results)
-
-
-
-
[Journal Article] Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension.2013
Author(s)
Taguchi I, Toyoda S, Takano K, Arikawa T, Kikuchi M, Ogawa M, Abe S, Node K, Inoue T
-
Journal Title
Hypertens Res
Volume: in press
Issue: 7
Pages: 608-613
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] The late phase inflammatory response after drug-eluting stent implantation.2013
Author(s)
Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T
-
Journal Title
Heart Vessels
Volume: in press
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] The late phase inflammatory response after drug-eluting stent implantation
Author(s)
Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T
URL
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Stentless balloon angioplasty with a novel balloon catheter,lacrosse non-slip element balloon
Author(s)
Kageyama M, Taguchi I, Tokura M, Nishiyama Y, Nasuno T, Nishino S, Yoneda S, Oda K, Abe S, Inoue T
Organizer
The 21th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics
Place of Presentation
Niigata, Japan
Related Report
-
-
-
-
-
-