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The Role of Adrenaline in Neurally Mediated Syncope

Research Project

Project/Area Number 22590797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical University (2011-2012)
Tokai University (2010)

Principal Investigator

SATO Kyoko  東京女子医科大学, 医学部, 講師 (80335942)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI Hiroyuki  東海大学, 医学部, 教授 (60195807)
KOMIYAMA Tomoyoshi  東海大学, 医学部, 准教授 (60439685)
MIKAMI Ayako  東海大学, 医学部, 講師 (50564697)
ISOZAKI Mitsuhiro  東海大学, 医学部, 助教 (90424332)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経調節性失神 / アドレナリン / 自律神経 / アドレナリンレセプター / アドレナリン受容体 / 遺伝子多型性
Research Abstract

yncope is a common problem associated with a poor quality of life. A majority of patients suffer from neurally mediated syncope (NMS), which is poorly understood in its pathophysiology. We evaluated cardiovascular autonomic functions as well as genetic polymorphisms of the α2B adrenoceptors (α2B-AR) predisposed to NMS patients (n=8, age 39±11 year, BMI 24±4 kg/m2) and healthy subjects (n=10, age 30±7 year, BMI 25±3 kg/m2). The standard autonomic function test (AFT) and head-up tilt (HUT) test were performed on each subject. Plasma catecholamines (CATs), renin, and aldosterone were measured after 30 minutes supine and at the end of the HUT. Twenty-four-hour urine collections were used to measure sodium and CATs excretion. A polymorphism of glutamic acid (Glu) repeats (Glu 12 or Glu 9, amino acids residues 301-303) present in the α2B AR was identified. We had three Glu 12/12, twelve Glu 12/9, and two Glu 9/9 subjects among the NMS patients and healthy controls; all of the NMS patients showed Glu 12/9. Syncopal subjects had Glu12/12 or Glu12/9 whereas subjects who had Glu9/9 did not have orthostatic symptom (OS). Therefore, we will investigate the possibility of this polymorphism as a marker of human vasomotor responses during orthostatic stress using subjects with and without NMS

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2013

    • Author(s)
      Kyoko Sato, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Kuniaki Otsuka
    • Journal Title

      The Autonomic Nervous System

      Volume: (in press)

    • NAID

      10031183955

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2013

    • Author(s)
      Kyoko Sato
    • Journal Title

      The Autonomic Nervous System

      Volume: 50

    • NAID

      10031183955

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Application for Genetic Evaluation of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2012

    • Author(s)
      Kyoko Sato, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Kuniaki Otsuka
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトアドレナリンレセプター遺伝子多型性と起立性調節障害との関連性について2012

    • Author(s)
      佐藤 恭子, 小見山智義, 西村芳子,柴田興一, 小林広幸, 大塚邦明
    • Organizer
      第65回日本自律神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2011

    • Author(s)
      Kyoko Sato, Tomoyoshi Komiyama, Hiroshi Kamiguchi, Ayako Mikami, Hiroyuki Kobayashi, Kuniaki Otsuka
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2011

    • Author(s)
      佐藤恭子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトアドレナリンレセプター遺伝子多型性と起立性調節障害との関連性について

    • Author(s)
      佐藤 恭子
    • Organizer
      第65回日本自律神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Application for Genetic Evaluation of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope

    • Author(s)
      Kyoko Sato
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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