Development of a novel treatment strategy that targets erythropoietin receptors and HIF
| Project/Area Number |
22590800
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KAGAYA Yutaka 東北大学, 大学院・医学系研究科, 教授 (90250779)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
武田 守彦 東北大学, 病院, 助教 (30375084)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Morihiko 東北大学, 病院, 助教 (30375084)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 心不全 / 心肥大 / エリスロポエチン / HIF / プロリル水酸化酵素 / 左室肥大 / 心筋保護 / 圧負荷 |
|---|
| Research Abstract |
Our objective was to determine whether novel strategies to treat heart failure with recombinant human erythropoietin (EPO) and a prolyl hydroxylase (PHD) inhibitor that stabilizes hypoxia-inducible factor (HIF) are useful. EPO protected the pressure-overload induced hypertrophied left ventricle in mice by maintaining left ventricular systolic function and improved the survival. The PHD inhibitor failed to demonstrate such a protective effect at least with the doses and treatment period usedin the present study. Further investigations are required to address the issue.
|
Report
(4 results)
Research Products
(20 results)
-
-
-
-
-
-
-
-
-
-
[Presentation] Prognostic significance of enhanced [^<18>F] fluorodeoxyglucose accumulation in the right ventricular free wall in patients with pulmonary hypertension2012
Author(s)
Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Aoki T, Yamamoto S, Wakayama-Oikawa M, Kagaya Y, Shimokawa H.
Organizer
Scientific Sessions of American Heart Association 2012
Place of Presentation
Los Angeles, U.S.A.
Year and Date
2012-11-05
Related Report
-
[Presentation] Prognostic significance of enhanced [18F] fluorodeoxyglucose accumulation in the right ventricular free wall in patients with pulmonary hypertension2012
Author(s)
Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Aoki T, Yamamoto S, Wakayama-Oikawa M, Kagaya Y, Shimokawa H.
Organizer
Scientific Sessions of American Heart Association 2012
Place of Presentation
Los Angels, U.S.A.
Related Report
-
[Presentation] 心不全と貧血2011
Author(s)
加賀谷豊
Organizer
第48回日本臨床生理学会学術集会
Place of Presentation
東京
Year and Date
2011-11-05
Related Report
-
-
[Presentation] 心不全と貧血2011
Author(s)
加賀谷豊
Organizer
第48回日本臨床生理学会学術集会
Place of Presentation
東京都(招待講演)
Year and Date
2011-11-04
Related Report
-
-
-
-
-
-
