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Involvement of TRP channels in the cardiac hypertrophy and cell death

Research Project

Project/Area Number 22590801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionAkita University

Principal Investigator

ITO Hiroshi  秋田大学, 大学院・医学系研究科, 教授 (10232464)

Co-Investigator(Kenkyū-buntansha) WATANABE Hiroyuki  秋田大学, 医学系研究科, 医学系研究科 (80323145)
OHBA Takayoshi  秋田大学, 医学系研究科, 助教 (80431625)
NOBORO Kiyoshi  秋田大学, 医学部, 特任講師 (40436192)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心筋細胞肥大 / 細胞死 / Ca流入性TRPチャネル / STIM-1 / Ca流入性TRPチャネル / STIM1 / STIM1
Research Abstract

In cardiac hypertrophy model, we could detect increases in the expression of TRPC1,-C3, -C6, brain natriuretic peptide (BNP), and NFAT activity, Ca entry, as well as increases in cell surface area. Gene silencing of the TRPC1 and pharmacological treatment with a pyrazole derivative or sildenafil attenuate the Ca entry and prevent cardiac hypertrophy. In analysis of stromal interaction molecule 1 (STIM1; known as a Ca sensor of intracellular Ca store) knockout mice, we provide evidence that STIM1 together with TRPC1 is crucial for the development of cardiac hypertrophy. Moreover, STIM1 contributes to cardiac fibrosis under the condition of pressure over load. Ultimately, TRPC/STIM1 system might become novel pharmacological target in the treatment of cardiac hypertrophy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (16 results) Book (3 results)

  • [Journal Article] Increased circulating CD3(+)/CD31(+)T cells in patients with acute coronary syndrome.2013

    • Author(s)
      Kakizaki M
    • Journal Title

      Heart Vessels

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased circulating CD3(+)/CD31(+)T cells in patients with acute coronary syndrome2012

    • Author(s)
      Kakizaki M, Nobori K, Watanabe H, Iino K, Ishida M, Ito H
    • Journal Title

      Heart Vessels

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effect of short-duration adaptive servo-ventilation therapy on cardiac function in patients with heart failure.2012

    • Author(s)
      Koyama T
    • Journal Title

      Circ J.

      Volume: 76(11) Pages: 2606-13

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1 and TRPA1 in pulmonary vagal afferents and their relations to airway sensitivity (Review)2011

    • Author(s)
      Watanabe H, Ohba T, Satoh K, Sano M, Shioya T, Ito H
    • Journal Title

      Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

      Volume: 10 Pages: 18-30

    • Related Report
      2012 Final Research Report
  • [Journal Article] Abnormal Coagulation and Platelet Profile in Patients with Obstructive Sleep Apnea Syndrome2011

    • Author(s)
      Terada S, Koyama T, Watanabe H, Makabe S, Igarashi G, Seki K ,Ito H
    • Journal Title

      Int.J.Cardiol.

      Volume: 146(3) Pages: 423-5

    • Related Report
      2012 Final Research Report
  • [Journal Article] TRPV1 and TRPA1 in pulmonary Vagal Afferents and their Relations to Airway Sensitivity2011

    • Author(s)
      Watanabe H, Ito H
    • Journal Title

      Anti-Inflammatory & Anti-Allergy Agents Medicinal Chemistry

      Volume: 10巻 Pages: 18-30

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV 1 and TRPA I in pulmonary Vagal Afferents and their Relations to Airway Sensitivity.2011

    • Author(s)
      Watanabe H, Ito H
    • Journal Title

      Anti-lnflammatory & Anti-Allergy Agents Medicinal Chemistry

      Volume: 10巻 Pages: 18-30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double Transgenic Mice Crossed GFP-LC3 Transgenic Mice with ? MyHC mCherry-LC3 mice are New and Useful Tool to Examine the Role of Autophagy in the Heart2010

    • Author(s)
      Terada M, Nobori K, Munehisa Y, Kakizaki M, Ohba T, Takahashi Y, Koyama T, Terada Y, Ishida M, Iino K, Kosaka T, Watanabe H ,Hasegawa H, Ito H
    • Journal Title

      Circ J

      Volume: 74(1) Pages: 203-206

    • Related Report
      2012 Final Research Report
  • [Journal Article] Abnormal Coagulation and Platelet Profile in Patients with Obstructive SI eep Apnea Syndrome.2010

    • Author(s)
      Terada S, Ito H
    • Journal Title

      Int.J.Cardiol.

      Volume: Vol146 3巻 Pages: 423-425

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double Transgenic Mice Crossed GFP-LC3 Transgenic Mice With αMyHC-mCherry-LC3 Transgenic Mice Are a New and Useful Tool to Examine the Role of Autophagy in the Heart.2010

    • Author(s)
      Trada M, Ito H
    • Journal Title

      Circ J.

      Volume: Vol74 1巻 Pages: 203-206

    • NAID

      10025941833

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia

    • Author(s)
      Watanabe H, Iino K, Ohba T, Ito H
    • Journal Title

      Current Topics in Medicinal Chemistry

    • Related Report
      2012 Final Research Report
  • [Presentation] Stromal interaction molecule 1 (STIM1) mediates MMP/TIMP Pathway in the Cardiac Fibrosis2013

    • Author(s)
      大場貴喜
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Slidenafil Inhibits TRPCs Related in the Dvelopment of Cardiomyocytes Hypertrophy2013

    • Author(s)
      木曽博典
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Transient receptor Potential (TRP) Channel and Hypertensive Heart Disease2013

    • Author(s)
      Watanabe H
    • Organizer
      The Korean Society of Hypertension
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] TRP Channel and cardiac hypertrophy2013

    • Author(s)
      Watanabe H
    • Organizer
      The Korean Society of Hypertension
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] 圧負荷による心肥大および心筋繊維化におけるSTIM1の役割2013

    • Author(s)
      大場貴喜
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 圧負荷による心肥大および心筋繊維化におけるSTIM1の役割2013

    • Author(s)
      大場貴喜
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] STIM1KOマウスにおける心肥大制御効果2012

    • Author(s)
      大場貴喜
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Stromal interaction molecule 1 (STIM1) governs cardiac hypertrophy and fibrosis in response to increased afterload2012

    • Author(s)
      大場貴喜
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Stromal interaction molecule 1(STIM1)governs cardiac hypertrophy and fibrosis in response to increased afterload.2012

    • Author(s)
      大場貴喜
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transient Receptor Potential Protein as Cardiac Non-selective Cation Channels Involved in Arrhythmia2011

    • Author(s)
      渡邊博之
    • Organizer
      第75回日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Transient Receptor Potential Protein as Cardiac Non-selective Cation Channels Involved in Arrhythmia2011

    • Author(s)
      渡邊博之
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transient Receptor Potential Channels as Novel Therapeutic Targets of Heart Failure2010

    • Author(s)
      Watanabe H
    • Organizer
      第14回日本心不全学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Transient Receptor Potential Channels as Novel Therapeutic Targets of Heart Failure.2010

    • Author(s)
      Watanabe H
    • Organizer
      第14回日本心不全学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] STIM1KOマウスにおける心肥大抑制効果

    • Author(s)
      大場貴喜
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stromal interaction molecule 1(STIM1)mediates MMP/TIMP Pathway in the Cardiac Fibrosis.

    • Author(s)
      大場貴喜
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Slidenafil Inhibits TRPCs Related Pathway in the Development of Cardiomyocytes Hypertrophy.

    • Author(s)
      木曽博典
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Book] Store-operated Ca2+ entry (SOCE) pathways2012

    • Author(s)
      Watanabe H, Ohba T, Ito H
    • Total Pages
      14
    • Publisher
      Shpringer Verlag
    • Related Report
      2012 Final Research Report
  • [Book] Store-operated Ca2+ Entry (SOCE) Pathways2012

    • Author(s)
      Watanabe H
    • Total Pages
      14
    • Publisher
      Springer Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] Store-operated Ca2+ entry (SOCE) pathways2012

    • Author(s)
      Watanabe H, Ohba T, Ito H
    • Publisher
      shpringer(In press)
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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