| Project/Area Number |
22590814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Keio University |
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Principal Investigator |
SHINMURA Ken 慶應義塾大学, 医学部, 講師 (70206332)
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| Research Collaborator |
SUEMATSU Makoto 慶應義塾大学, 医学部, 教授 (00206385)
FUKUDA Keiichi 慶應義塾大学, 医学部, 教授 (20199227)
OTA Shigeo 日本医科大学, 医学研究科, 教授 (00125832)
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
ADACHI Takeshi 防衛医科大学校, 医学教育部・医学科専門課程, 教授 (50231931)
SANO Motoaki 慶應義塾大学, 医学部, 准教授 (30265798)
KAMIMURA Naomi 日本医科大学, 医学研究科, 講師 (60283800)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カロリー制限 / 心筋虚血 / 心保護 / 電子伝達系 / 脱アセチル化 / ミトコンドリア / sirtuin / SIRT1 / 再灌流傷害 / 遺伝子発現 / 補体 / 老化 / シグナル伝達 / ストレス |
|---|
| Research Abstract |
Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. We speculated that CR primes mitochondria for stress-resistance by post-transcriptional modification of specific mitochondrial proteins. We found that deacetylation of
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