| Project/Area Number |
22590817
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YAMAZAKI Satoru 独立行政法人国立循環器病研究センター, 研究所, 室長 (70348796)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAKAZE Masafumi 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 部長 (20294069)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TAKASHIMA Seiji 大阪大学, 医学系研究科, 准教授 (90379272)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
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| Keywords | 遺伝子 / 核酸 / ゲノム / シグナル伝達 / 循環器・高血圧 |
|---|
| Research Abstract |
In this research project, we were able to establish in vivo enhancer system using zebrafish, in vivo ischemia systems and purification system of trans-regulatory factors to purpose of analyzing the enhancer in heart failure. Although identification of HB-EGF enhancer left some problems, combining these systems is expected to lead to the development of therapies and new pathogenesis of heart failure in future.
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