Identification and functional analysis of the factors that interact with cardiac protective factor HB-EGF
Project/Area Number |
22590817
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
YAMAZAKI Satoru 独立行政法人国立循環器病研究センター, 研究所, 室長 (70348796)
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Co-Investigator(Kenkyū-buntansha) |
KITAKAZE Masafumi 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 部長 (20294069)
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Co-Investigator(Renkei-kenkyūsha) |
TAKASHIMA Seiji 大阪大学, 医学系研究科, 准教授 (90379272)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 遺伝子 / 核酸 / ゲノム / シグナル伝達 / 循環器・高血圧 |
Research Abstract |
In this research project, we were able to establish in vivo enhancer system using zebrafish, in vivo ischemia systems and purification system of trans-regulatory factors to purpose of analyzing the enhancer in heart failure. Although identification of HB-EGF enhancer left some problems, combining these systems is expected to lead to the development of therapies and new pathogenesis of heart failure in future.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice.2013
Author(s)
Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 304(10)
Issue: 10
Pages: H1361-H1369
DOI
Related Report
Peer Reviewed
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[Journal Article] Ablation of Rnf213 retards progression of diabetes in the Akita mouse2013
Author(s)
Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A
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Journal Title
Biochem Biophys Res Commun
Volume: 432
Issue: 3
Pages: 519-525
DOI
Related Report
Peer Reviewed
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[Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs2012
Author(s)
Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
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Journal Title
Cardiovasc Drugs Ther.
Volume: 26
Issue: 3
Pages: 217-226
DOI
Related Report
Peer Reviewed
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[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010
Author(s)
5.Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S
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Journal Title
J Biol Chem.
Volume: 285(41)
Issue: 41
Pages: 31337-47
DOI
Related Report
Peer Reviewed
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[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
Author(s)
Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S
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Journal Title
Nat Cell Biol.
Volume: 12(6)
Issue: 6
Pages: 583-90
DOI
Related Report
Peer Reviewed
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[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010
Author(s)
Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I
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Journal Title
J Mol Cell Cardiol.
Volume: 48(6)
Issue: 6
Pages: 1280-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.2010
Author(s)
8.Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M
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Journal Title
Biochem Biophys Res Commun.
Volume: 393(1)
Issue: 1
Pages: 55-60
DOI
Related Report
Peer Reviewed
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[Presentation] Impact of the Polymorphisms of Renin-Angiotensin System on Prognosis in Hypertrophic Cardiomyopathy in the Era of Cardiac Magnetic Resonance.2013
Author(s)
Akira Funada, Hideaki Kanzaki, Satoru Yamazaki, Takuya Hasegawa, Yasuo Sugano, Takahiro Ohhara , Masanori Asakura, Masaharu Ishihara, Satoshi Yasuda, Wataru Shimizu, Hisao Ogawa, Masafumi Kitakaze, Toshihisa Anzai
Organizer
第77回日本循環器学会学術総会
Place of Presentation
横浜
Related Report
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[Presentation] Dipeptidyl-peptidase IV Inhibitor Improved Cardiac Function and Survival in Mice with Pressure Overload Heart Failure.2012
Author(s)
Ayako Takahashi, Masanori Asakura, Shin Ito, Min Kyung-Duk, Kazuhiro Shindo , Yin Yan, Yulin Liao, Satoru Yamazaki, Shoji Sanada, Yoshihiro Asano, H atsue Ishibashi-Ueda, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Naoki Mochizuki, Masafumi Kitakaze
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Related Report
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[Presentation] Structure and function of novel AAA+/Ubiquitin ligase mysterin.2011
Author(s)
Daisuke Morito, Kouki Nishikawa, Wangyang Liu, Satoru Yamazaki, Toshiaki Hitomi, Hatasu Kobayashi, Norio Matsuura, Susumu Miyamoto, Seiji Takashima, Nobuo Hashimoto, Yoshinori Fujiyoshi, Akio Koizumi, Kazuhiro Nagata
Organizer
Cold Spring Harbor Asia Conference, "Protein Homeostasis in Health & Disease"
Place of Presentation
Suzhou (China)
Related Report
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[Presentation] Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model.2010
Author(s)
Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze
Organizer
American Heart Association 83rd Scientific Sessions
Place of Presentation
Chicago (USA)
Related Report
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