Development of novel therapy for atherosclerosis using adipose tissue-derived stem cells
| Project/Area Number |
22590822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIRATA Yasunobu 東京大学, 医学部附属病院, 特任准教授 (70167609)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Daisuke 東京大学, 医学部附属病院, 特任准教授 (40393194)
NISHIMATSU Hiroaki 東京大学, 医学部附属病院, 准教授 (60251295)
TAKAHASHI Masao 東京大学, 医学部附属病院, 助教 (00447418)
TANAKA Kimie 東京大学, 医学部附属病院, 助教 (30508065)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子血管病態学 / 移植・再生医療 / 遺伝子 / 細胞・組織 / 循環器・高血圧 / 生理活性 |
|---|
| Research Abstract |
Adipose tissue-derived stem cells (ASC) can differentiate to various kinds of cells including vascular cells. In the present studies, we showed that ASC were able to be introduced to vascular endothelial cells, and that ASC suppressed neointimal formation caused by vessel injury. ASC also improved the cavernous function. These effects were caused by paracrine effects of ASC.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome.2013
Author(s)
Ogawa N, Imai Y, Nishimura H, Kato M, Takeda N, Nawata K, Taketani T, Morota T, Takamoto S, Nagai R, Hirata Y.
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Journal Title
Int Heart J
Volume: 54
Pages: 23-6
NAID
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[Journal Article] Prognostic implication of macrocytosis on adverse outcomes after coronary intervention.2012
Author(s)
Myojo M, Iwata H, Kohro T, Sato H, Kiyosue A, Ando J, Sawaki D, Takahashi M, Fujita H, Hirata Y, Nagai R.
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Journal Title
Atherosclerosis
Volume: 221
Pages: 148-53
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[Journal Article] The ATP-binding cassette transporter subfamily G member 2 protectsagainst pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.2012
Author(s)
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 32
Pages: 654-61
Related Report
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[Journal Article] The ATP-binding cassette transporter subfamily G member 2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.2012
Author(s)
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 654-61
Related Report
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[Journal Article] The ATP-binding cassette transporter subfamily G member 2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response2012
Author(s)
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 32
Pages: 654-661
DOI
Related Report
Peer Reviewed
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[Journal Article] Japanese-Western consensus meeting on biomarkers2011
Author(s)
Maisel AS, Nakao K, Ponikowski P, Peacock WF, Yoshimura M, Suzuki T, Tsutamoto T, Filippatos GS, Saito Y, Seino Y, Minamino N, Hirata Y, Mukoyama M, Nishikimi T, Nagai R.
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Journal Title
Int Heart
Volume: 52
Pages: 253-65
Related Report
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[Journal Article] EvaluatingJapanesepatientswith the Marfan syndrome using high-throughput microarray-based mutational analysis of fibrillin-1 gene.2011
Author(s)
Ogawa N, Imai Y, Takahashi Y, Nawata K, Hara K, Nishimura H, Kato M, Takeda N, Kohro T, Morita H, Taketani T, Morota T, Yamazaki T, Goto J, Tsuji S, Takamoto S, Nagai R, Hirata Y.
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Journal Title
Am J Cardiol.
Volume: 108
Pages: 1801-7
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[Journal Article] The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.2010
Author(s)
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 30
Pages: 2128-35
Related Report
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[Journal Article] Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia.2010
Author(s)
Kiyose K, Hanaoka K, Oushiki D, Nakamura T, Kajimura M, Suematsu M, Nishimatsu H, Yamane T, Terai T, Hirata Y, Nagano T
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Journal Title
J Am Chem Soc.
Volume: 132
Pages: 15846-8
Related Report
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[Journal Article] miR-200b precursor can ameliorate renal tubulointerstitial fibrosis2010
Author(s)
Oba S, Kumano S, Suzuki E, Nishimatsu H, Takahashi M, Takamori H, Kasuya M, Ogawa Y, Sato K, Kimura K, Homma Y, Hirata Y, Fujita T.
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[Presentation] マルファン症候群専門外来からみた日本人マルファン症候群の臨床像2011
Author(s)
藤田大司,今井靖,小川直美,西村敬史,加藤昌義,嶋田正吾,竹谷剛,師田哲郎,青木美穂子,平田恭信,永井良三
Organizer
第59回日本心臓病学会
Place of Presentation
神戸
Related Report
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[Presentation] マルファン症候群における口腔所見の意義歯周病は極めて高頻度2011
Author(s)
青木美穂子,今井靖,藤田大司,加藤昌義,西村敬史,小川直美,竹谷剛,師田哲郎,鈴木淳一,平田恭信,永井良三
Organizer
第59回日本心臓病学会
Place of Presentation
神戸
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[Book] 循環器病学2012
Author(s)
永井良三、山下尋史、絹川弘一郎、今井靖
Publisher
日本医事新報4581
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