The role of cholinergic anti-inflammatory pathway in the development of cardiovascular diseases.
| Project/Area Number |
22590830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
ICHIKI Tosihiro 九州大学, 大学院・医学研究院, 教授 (80311843)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Kotaro 九州大学, 大学院・医学研究院, 助教 (50467908)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | コリン作動性抗炎症経路 / コリンエステラーゼ阻害薬 / 自然免疫 / 動脈硬化 / 酸化ストレス / 循環器・高血圧 / 血管新生 / 迷走神経 / 抗炎症 / サイトカイン / ドネペジル / interleukin-1β |
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| Research Abstract |
Activation of cholinergic anti-inflammatory pathway by acetylcholine esterase inhibitors attenuated atherogenesis in apolipoprotein E-deficient mice fed a high-fat diet and blood flow recovery in a hindlimb ischemia model in mice. These effects seemed to be mediated by suppression of cytokine expression. Acetylcholine esterase inhibitors may be a novel strategy for the treatment of cardiovascular diseases.
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Report
(4 results)
Research Products
(20 results)
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[Presentation] Biology 2010 Scientific Sessions2010
Author(s)
Arteriosclerosis, Thrombosis and Vascula
Organizer
Cholinesterase inhibitor attenuates atherogenesis in apolipoprotein E knockout mice through anti-oxidant and anti-inflammatory effects
Place of Presentation
San Francisco, California, USA
Related Report
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