The role of cholinergic anti-inflammatory pathway in the development of cardiovascular diseases.

• Project/Area Number: 22590830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: ICHIKI Tosihiro 九州大学, 大学院・医学研究院, 教授 (80311843)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Kotaro 九州大学, 大学院・医学研究院, 助教 (50467908)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: コリン作動性抗炎症経路 / コリンエステラーゼ阻害薬 / 自然免疫 / 動脈硬化 / 酸化ストレス / 循環器・高血圧 / 血管新生 / 迷走神経 / 抗炎症 / サイトカイン / ドネペジル / interleukin-1β

Research Abstract

Activation of cholinergic anti-inflammatory pathway by acetylcholine esterase inhibitors attenuated atherogenesis in apolipoprotein E-deficient mice fed a high-fat diet and blood flow recovery in a hindlimb ischemia model in mice. These effects seemed to be mediated by suppression of cytokine expression. Acetylcholine esterase inhibitors may be a novel strategy for the treatment of cardiovascular diseases.

Research Products

• [Journal Article] Acetylcholinesterase Inhibitors Attenuate Angiogenesis (2012)
  • Author(s): Miyazaki R, Ichiki T, Hashimoto T, Ikeda J, Kamiharaguchi A, Narabayashi E, Matsuura H, Takeda K, Sunagawa K
  • Journal Title: Clin Sci (Lond) Volume: 123 Pages: 241-249
  • Peer Reviewed
• [Journal Article] Acetylcholinesterase Inhibitors Attenuate Angiogenesis (2012)
  • Author(s): Miyazaki R, et al
  • Journal Title: Clinical Science Volume: (In press) Issue: 4 Pages: 241-249
  • DOI: 10.1042/cs20110633
  • Peer Reviewed
• [Journal Article] Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells. (2012)
  • Author(s): Ichiki T
  • Journal Title: Regulatory Peptide Volume: 177 Issue: 1-3 Pages: 35-39
  • DOI: 10.1016/j.regpep.2012.04.005
  • Peer Reviewed
• [Journal Article] Inhibition of MDM2 Attenuates Neointimal Hyperplasia via Suppression of Vascular Proliferation and Inflammation (2011)
  • Author(s): Hashimoto T, et al
  • Journal Title: Cardiovascular Research Volume: 91 Issue: 4 Pages: 386-393
  • DOI: 10.1093/cvr/cvr108
  • Peer Reviewed
• [Journal Article] Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoproteinE-knockout mice (2010)
  • Author(s): Inanaga K, Ichiki T, Miyazaki R, Takeda K, Hashimoto T, Matsuura H, Sunagawa K
  • Journal Title: Atherosclerosis Volume: 213 Pages: 52-58
  • Peer Reviewed
• [Journal Article] Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice. (2010)
  • Author(s): Inanaga K, Ichiki T, Miyazaki R, Takeda K, Hashimoto T, Matsuura H, Sunagawa K.
  • Journal Title: Atherosclerosis Volume: 213 Pages: 52-58
  • NAID: 120005227204
  • Peer Reviewed
• [Presentation] Role of Acetylcholinesterase in Atherogenesis and Angiogenesis (2012)
  • Author(s): Toshihiro Ichiki, Kenji Sunagawa
  • Organizer: 第76回日本循環器学会総会
  • Place of Presentation: 福岡
• [Presentation] 長寿遺伝子SIRT1はアンジオテンシンIIタイプ1受容体の発現と機能を抑制する (2011)
  • Author(s): 市来俊弘
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター(栃木)(シンポジウム)
  • Year and Date: 2011-10-20
• [Presentation] アルツハイマー病治療薬のドネペジルは血管新生と腫瘍形成を抑制する (2011)
  • Author(s): 市来俊弘
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2011-09-25
• [Presentation] Inhibition of MDM2 attenuates maladaptive vascular remodeling after vascular injury (2011)
  • Author(s): 橋本亨
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-08-03
• [Presentation] Pharmacological activation of the cholinergic anti-inflammatory pathway ameliorates atherosclerosis in apolioprotein E-deficient mice (2011)
  • Author(s): 橋本亨
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2011-07-15
• [Presentation] Anti-atherogenic and anti-angiogenic effects of donepezil: a drug for Alzheimer's disease (2011)
  • Author(s): Ichiki T, Sunagawa K
  • Organizer: 60th Annual Scientific Sessions of American College of Cardiology
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Pharmacological activation of the cholinergic anti-inflammatory pathway ameliorates atherosclerosis in apolioprotein E-deficient mice (2011)
  • Author(s): Toru Hashimoto, Toshihiro Ichiki
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 札幌市
• [Presentation] アルツハイマー病治療薬のドネペジルは血管新生と腫瘍形成を抑制する (2011)
  • Author(s): 市来俊弘、砂川賢二
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] MDM2阻害薬Nutlin-3による血管傷害後新生内膜形成の抑制-新生内膜形成における転写因子の役割 (2010)
  • Author(s): 市来俊弘
  • Organizer: 第51回日本脈管学会総会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2010-10-14
• [Presentation] Anti-atherogenic and anti-angiogenic effect of cholinesterase inhibitors. (2010)
  • Author(s): Ichiki T, Inanaga K Miyazaki R, Sunagawa K.
  • Organizer: 19^<th> Intrenational Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: 九州大学百年講堂(福岡)
  • Year and Date: 2010-09-22
• [Presentation] Biology 2010 Scientific Sessions (2010)
  • Author(s): Arteriosclerosis, Thrombosis and Vascula
  • Organizer: Cholinesterase inhibitor attenuates atherogenesis in apolipoprotein E knockout mice through anti-oxidant and anti-inflammatory effects
  • Place of Presentation: San Francisco, California, USA
• [Presentation] Anti-atherogenic and anti-angiogenic effect of cholinesterase inhibitors (2010)
  • Author(s): Ichiki T, Inanaga K Miyazaki R, Sunagawa K
  • Organizer: 19th Intrenational Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: Fukuoka, Japan
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/3_shinkekkan/
• [Remarks] 九州大学大学院医学研究院 寄附講座 先端心血管治療学
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/3_shinkekkan/