| Project/Area Number |
22590831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Tsutomu 昭和大学, 医学部, 教授 (00167610)
KOBA Shinji 昭和大学, 医学部, 講師 (20276546)
NAGASHIMA Masaharu 昭和大学, 医学部, 助教 (20468606)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子血管病態学 / インクレチン / DPP-4阻害剤 / 糖尿病 / 動脈硬化 / マクロファージの泡沫化 / マクロファージ / 泡沫化 / CD36 / ACAT-1 |
|---|
| Research Abstract |
The present study shows that incretin-based therapy using DPP-4 inhibitors and GLP-1 analogs, new treatment of diabetes, exerts anti-atherosclerotic effects, other than glucose lowering effect, leading to the prevention of diabetic macroangiopahy (coronary arterydisease, cerebrovascular disease, and arteriosclerosis obliterans). The pleiotrophic effects are attributed to anti-atherogenesis of GLP-1 and/or GIP on vascular cells, such as endothelial cells, vascular smooth muscle cells, and monocytes/macrophages, via individual receptors followed by cAMP activation.
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