| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In this research, we comprehensively analyzed the role of periostin, stress-responsive secretory protein, on atherogenesis in aortic valve and aorta both in vitro and in vivo. The thickening and calcification of aortic valves and aorta were significantly reduced in periostin/apoE double knockout mice. Furthermore, The capacity of adhesion and invasion of murine bone marrow-derived CD14 positive cells into endothelial cells was enhanced by periostin administration. In rat valvular interstitial cells and aortic smooth muscle cells, periostin administration exerted anti-apoptosis and akt activation. Periostin also promoted bone matrix production by valvular interstitial cells and CD14 expression in murine bone marrow-derived CD14 positive cells.
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