Elucidation for the role of stress-responsive secretory proteins on the progression of atherosclerotic aortic valves and vascular diseases
| Project/Area Number |
22590833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Defense Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈硬化 / 血管新生 / マトリックスメタロプロテアーゼ / 心臓弁膜症 / 炎症 |
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| Research Abstract |
In this research, we comprehensively analyzed the role of periostin, stress-responsive secretory protein, on atherogenesis in aortic valve and aorta both in vitro and in vivo. The thickening and calcification of aortic valves and aorta were significantly reduced in periostin/apoE double knockout mice. Furthermore, The capacity of adhesion and invasion of murine bone marrow-derived CD14 positive cells into endothelial cells was enhanced by periostin administration. In rat valvular interstitial cells and aortic smooth muscle cells, periostin administration exerted anti-apoptosis and akt activation. Periostin also promoted bone matrix production by valvular interstitial cells and CD14 expression in murine bone marrow-derived CD14 positive cells.
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Report
(4 results)
Research Products
(12 results)
