Risk factors for inflammatory obstructive pulmonary diseases: a prospective cohort study.

• Project/Area Number: 22590834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: SAKAMOTO Tohru 筑波大学, 医学医療系, 准教授 (50282356)
• Co-Investigator(Kenkyū-buntansha): HIZAWA Nobuyuki 筑波大学, 医学医療系, 教授 (00301896) ; NOGUCHI Emiko 筑波大学, 医学医療系, 准教授 (40344882)
• Co-Investigator(Renkei-kenkyūsha): TAMARI Mayumi 独立行政法人理化学研究所, ゲノム医科学研究センター, チームリーダー (00217184)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 喘息 / 慢性閉塞性肺疾患 / 遺伝子多型 / 前向き研究 / コホート / 肺機能検査 / 閉塞性肺疾患 / ゲノムワイド関連解析

Research Abstract

Inflammatory obstructive pulmonary diseases such as asthma and COPD are heterogeneous diseases modified by interaction between environmental andintrinsic host factors. This study demonstrated that airflow obstruction is associated withsingle-nucleotide polymorphisms (SNPs) of the TSLP gene, and that annual decline of FEV1 is associated with that of the Nrf2 gene. It has been revealed that the persons with the new onset of COPD have significantly lower FEV1/FVC than the normal controls at thetime point of the study entry. Furthermore, the persons with the new onset of asthma have significantly larger annual decline of FEV1 than the normal controls at the study entry, suggesting that adult-onset asthma patients have rapid decline of FEV1 even before affection of the disease.

Research Products

• [Journal Article] The search for common pathways underlying asthma and COPD (2013)
  • Author(s): Kaneko Y, Yatagai Y, Yamada H, Iijima H, Masuko H, Sakamoto T, Hizawa N
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 8 Pages: 65-78
  • Peer Reviewed
• [Journal Article] A distinct sensitization pattern associated with asthma and the thymic stromal lymphopoietin (TSLP) genotype (2013)
  • Author(s): Iijima H, Kaneko Y, Yamada H, Yatagai Y, Masuko H, Sakamoto T, Nai t o T, Hirota T, Tamari M, Konno S, Nishimura M, Noguchi E, Hizawa N.
  • Journal Title: Allergol Int. Volume: 62(1) Pages: 123-30
  • NAID: 130004477178
  • Peer Reviewed
• [Journal Article] Asthma phenotypes in Japanese adults - their associations with the CCL5 and ADRB2 genotypes (2013)
  • Author(s): Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Yatagai Y, Yamada H, Konno S, Nishimura M, Noguchi E, Hizawa N
  • Journal Title: Allergol Int Volume: 62(1) Pages: 113-21
  • NAID: 130004477174
  • Peer Reviewed
• [Journal Article] Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 and ADRB2 Genotypes. (2013)
  • Author(s): Kaneko Y.
  • Journal Title: Allergol Int. Volume: 62 Pages: 113-21
  • Peer Reviewed
• [Journal Article] A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype. (2013)
  • Author(s): Iijima H.
  • Journal Title: Allergol Int. Volume: 62 Pages: 123-30
  • Peer Reviewed
• [Journal Article] The search for common pathways underlying asthma and COPD. (2013)
  • Author(s): Kaneko Y.
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 8 Pages: 65-78
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population (2012)
  • Author(s): Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T
  • Journal Title: Nat Genet Volume: 44(11) Pages: 1222-6
  • Peer Reviewed
• [Journal Article] The opposite effect of the CCL5 gene on asthma and baseline FEV(1) in nonasthmatic healthy adults (2012)
  • Author(s): Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Hizawa N
  • Journal Title: Allergol Int Volume: 61(1) Pages: 177-8
  • NAID: 130004873037
  • Peer Reviewed
• [Journal Article] The opposite effect of the CCL5 gene on asthma and baseline FEV(1) in nonasthmatic healthy adults. (2012)
  • Author(s): Kaneko Y.
  • Journal Title: Allergol Int. Volume: 61 Pages: 177-8
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (2012)
  • Author(s): Hirota T.
  • Journal Title: Nat Genet. Volume: 44 Pages: 1222-6
  • Peer Reviewed
• [Journal Article] COPDと喘息 オーバーラップ症候群の治療はどうするべきか (2012)
  • Author(s): 坂本 透
  • Journal Title: Medicina Volume: 49 Pages: 474-6
• [Journal Article] Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies (2011)
  • Author(s): Hirota T, Saeki H, Tomita K, Tanaka S, Ebe K, Sakashita M, Yamada T, Fujieda S, Miyatake A, Doi S, Enomoto T, Hizawa N, Sakamoto T, Masuko H, Sasaki T, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Noguchi E, Kamatani N, Nakamura Y, Kubo M, Tamari
  • Journal Title: PLoS One Volume: 6(11)
  • Peer Reviewed
• [Journal Article] COPD疾患感受性遺伝子 (2011)
  • Author(s): 坂本透、檜澤伸之
  • Journal Title: 日本臨床 Volume: 69(10) Pages: 1758-62
• [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations (2011)
  • Author(s): Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S,Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N
  • Journal Title: PLoS Genet Volume: 7(7)
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population (2011)
  • Author(s): Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Doi S, Fujita K, Miyatake A, Enomoto T, Miyagawa T, Adachi M, Tanaka H, Niimi A, Matsumoto H, Ito I, Masuko H, Sakamoto T, Hizawa N, Taniguchi M, Lima JJ, Irvin CG, Peters SP, Himes BE, Litonjua AA, Ta
  • Journal Title: Nat Genet Volume: 43(9) Pages: 893-6
  • Peer Reviewed
• [Journal Article] An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study. (2011)
  • Author(s): Masuko H, Sakamoto T, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Hizawa N
  • Journal Title: BMC Med Genet Volume: 12 Pages: 97-97
  • NAID: 120007137552
  • Peer Reviewed
• [Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes (2011)
  • Author(s): Masuko H, Sakamoto T, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Hizawa N
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 6 Pages: 181-9
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma (2011)
  • Author(s): Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias
  • Journal Title: Am JRespir Cell Mol Biol Volume: 44(6) Pages: 787-93
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma (2011)
  • Author(s): Harada M, Hirota T, Jodo Al, et al
  • Journal Title: Am J Respir Cell Mol Biol Volume: 44 Issue: 6 Pages: 787-793
  • DOI: 10.1165/rcmb.2009-0418oc
  • Peer Reviewed
• [Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects : association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes (2011)
  • Author(s): Masuko H, et al.
  • Journal Title: Int J Chron Obstruct Pulmon Dis Volume: 6 Pages: 181-189
  • DOI: 10.2147/copd.s16383
  • Peer Reviewed
• [Journal Article] An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1 : a longitudinal retrospective cohort study (2011)
  • Author(s): Masuko H, et al.
  • Journal Title: BMC Med Genet Volume: 12 Issue: 1 Pages: 97-97
  • DOI: 10.1186/1471-2350-12-97
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population (2011)
  • Author(s): Hirota, T., et.al.
  • Journal Title: Nat Genet Volume: 43(9) Issue: 9 Pages: 893-6
  • DOI: 10.1038/ng.887
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations (2011)
  • Author(s): Noguchi E, 他33名
  • Journal Title: PLoS Genet Volume: 7 Issue: 7 Pages: e1002171-e1002171
  • DOI: 10.1371/journal.pgen.1002171
  • Peer Reviewed
• [Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis : case-control studies (2011)
  • Author(s): Hirota, T., et.al.
  • Journal Title: PLoS One Volume: 6(11) Issue: 11 Pages: e26987-e26987
  • DOI: 10.1371/journal.pone.0026987
  • Peer Reviewed
• [Journal Article] Lower FEVI in non-COPD, non-asthmatic subjects : association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes (2011)
  • Author(s): Hironori Masuko
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: VOL.60 Pages: 181-189
  • Peer Reviewed
• [Presentation] 喫煙が呼吸器系の形態と機能に及ぼす影響 (2013)
  • Author(s): 坂本透
  • Organizer: 第53回日本呼吸器学会学術講演会シンポジウム9
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2013-04-19
• [Presentation] 気管支端息患者phenotypeとADRB2遺伝子多型の検討 (2013)
  • Author(s): 谷田貝洋平(代表)、坂本透、他6名
  • Organizer: 第53回日本呼吸器学会学術講演会ミニシンポジウム92
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2013-04-19
• [Presentation] 健常成人の総IgE値,一秒量におけるMUC5B遺伝子の役割 (2013)
  • Author(s): 金子美子(代表)、坂本透、他8名
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2013-04-19
• [Presentation] 日本人における閉塞性換気障害に影響を与える遺伝因子 (2013)
  • Author(s): 山田英恵(代表)、坂本透、他9名
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2013-04-19
• [Presentation] 吸入抗原特異的IgE抗体-MAST26、MAST33とImmunoCARの比較- (2012)
  • Author(s): 飯島弘晃(代表)、坂本透、他4名
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-11-29
• [Presentation] 日本人血清総IgE 値のケノムワイド関連解析 (2012)
  • Author(s): 谷田貝洋平(代表)、坂本透、他14名
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-11-29
• [Presentation] 喘息とCOPDにおけるCommon pathwayの探索 (2012)
  • Author(s): 金子美子(代表)、坂本透、他4名
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-11-29
• [Presentation] 気管支端息におけるアトピー分類と呼吸機能の解析 (2012)
  • Author(s): 山田英恵(代表)、坂本透、他7名
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-11-29
• [Presentation] Genetic polymorphisms associated with total IgE levels in the Japanese population: A replication analysis by genome-wide association study (2012)
  • Author(s): Masuko H. (代表)、Sakamoto T. 他9名
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center(San Francisco, USA)
  • Year and Date: 2012-05-18
• [Presentation] The search for common pathways for asthma and COPD. (2012)
  • Author(s): Knaneko Y.(代表)、Sakamoto T. 他5名
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center(San Francisco, USA)
  • Year and Date: 2012-05-18
• [Presentation] Influences of smoking on the association between thymic stromal lymphopoietin (TSLP) genotypes and IgE responses to inhaled allergens (2012)
  • Author(s): Iijima H. (代表)、Sakamoto T. 他8名
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center(San Francisco, USA)
  • Year and Date: 2012-05-18
• [Presentation] cluster分析を用いた成人気管支喘息患者表現型の検討 (2012)
  • Author(s): 金子美子(代表)、坂本透、他6名
  • Organizer: 第52回日本呼吸器学会学術講演会(神戸)
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-04-20
• [Presentation] 日本人における血清総IgE 値に影響を与える遺伝因子-網羅的遺伝子解析による追試- (2012)
  • Author(s): 谷田貝洋平(代表)、坂本透、他8名
  • Organizer: 第52回日本呼吸器学会学術講演会(神戸)
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-04-20
• [Presentation] 喘息患者における吸入抗原特異的IgE抗体検索について (2012)
  • Author(s): 飯島弘晃
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] 日本人における血清総IgE値に影響を与える遺伝因子―網羅的遺伝子解析による追試― (2012)
  • Author(s): 谷田貝洋平
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] cluster分析を用いた成人気管支喘息患者表現型の検討 (2012)
  • Author(s): 金子美子
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] Influences of smoking on the association between thymic stromal lymphopoietin (TSLP) genotypes and IgE responses to inhaled allergens. (2012)
  • Author(s): Iijima H.
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center（San Francisco, USA）
• [Presentation] The search for common pathways for asthma and COPD. (2012)
  • Author(s): Knaneko Y.
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center（San Francisco, USA）
• [Presentation] Genetic polymorphisms associated with total IgE levels in the Japanese population: A replication analysis by genome-wide association study. (2012)
  • Author(s): Masuko H.
  • Organizer: American Thoracic Society 2012 International Conference
  • Place of Presentation: Moscone Center（San Francisco, USA）
• [Presentation] 吸入抗原特異的IgE抗体－MAST26、MAST33とImmunoCAPの比較－ (2012)
  • Author(s): 飯島弘晃
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] 日本人血清総IgE値のゲノムワイド関連解析 (2012)
  • Author(s): 谷田貝洋平
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] 喘息とCOPDにおけるCommon pathwayの探索 (2012)
  • Author(s): 金子美子
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] 気管支喘息におけるアトピー分類と呼吸機能の解析 (2012)
  • Author(s): 山田英恵
  • Organizer: 第62回日本アレルギー学会秋期学術大会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] 23価肺炎球菌ワクチンの特徴とその役割～COPD患者に対する臨床効果エビデンスとガイドライン～ (2011)
  • Author(s): 坂本透
  • Organizer: 第12回日本医療マネージメント学会茨城県支部学術集会ランチョンセミナー4
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2011-11-26
• [Presentation] COPD症例に対する23価肺炎球菌ワクチン接種の重要性 (2011)
  • Author(s): 坂本透
  • Organizer: 第22回茨城県薬剤師学術大会ランチョンセミナー
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2011-11-20
• [Presentation] 健常者における1秒量の経年変化とNrf2遺伝子多型の検討 (2011)
  • Author(s): 増子裕典(代表)、坂本透、他7名
  • Organizer: 第23回日本アレルギー学会秋期臨床大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-11-10
• [Presentation] CCL5-28C>G遺伝子多型が健常成人一秒率に与える影響 (2011)
  • Author(s): 金子美子(代表)、坂本透、他5名
  • Organizer: 第23回日本アレルギー学会秋期臨床大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-11-10
• [Presentation] Genotypes at CCL5 And TF promoter polymorphisms influence the phenotypic differences in adult asthma (2011)
  • Author(s): Kaneko Y.(代表)、Sakamoto T. 他6名
  • Organizer: 107th American Thoracic Society International Conference
  • Place of Presentation: Plaza Building (Denver, USA)
  • Year and Date: 2011-05-13
• [Presentation] Cluster analyses of IgE responsiveness identified environmental risk factors for asthma (2011)
  • Author(s): Iijima H. (代表)、Sakamoto T. 他8名
  • Organizer: 107th American Thoracic Society International Conference
  • Place of Presentation: Plaza Building (Denver, USA)
  • Year and Date: 2011-05-13
• [Presentation] A nrf2 polymorphism was associated with annual FEV1 decline in the Japanese population (2011)
  • Author(s): Masuko H.(代表)、Sakamoto T. 他6名
  • Organizer: 107th American Thoracic Society International Conference
  • Place of Presentation: Plaza Building (Denver, USA)
  • Year and Date: 2011-05-13
• [Presentation] 健常者における1秒量の経年変化とNrf2遺伝子多型の検討 (2011)
  • Author(s): 増子裕典(代表)、坂本透、他6名
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-04-14
• [Presentation] 健常者一秒率におけるCCL5-28G対立遺伝子の意義について (2011)
  • Author(s): 金子美子(代表)、坂本透、他4名
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-04-14
• [Presentation] 健常者における1秒量の経年変化とNrf2遺伝子多型の検討 (2011)
  • Author(s): 増子裕典, 等
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] 健常者一秒率におけるCCL5-28G対立遺伝子の意義について (2011)
  • Author(s): 金子美子, 等
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] A NRF2 Polymorphism Was Associated With Annual FEV1 Decline In The Japanese Population (2011)
  • Author(s): Masuko H, et al.
  • Organizer: 107^<th> American Thoracic Society International Conference
  • Place of Presentation: Denver, Colorado (USA)
• [Presentation] Genotypes At CCL5 And TF Promoter Polymorphisms Influence The Phenotypic Differences In Adult Asthma (2011)
  • Author(s): Kaneko Y, et al.
  • Organizer: 107^<th> American Thoracic Society International Conference
  • Place of Presentation: Denver, Colorado
• [Presentation] CCL5-28C>G遺伝子多型が健常成人一秒率に与える影響 (2011)
  • Author(s): 金子美子, 等
  • Organizer: 第23回日本アレルギー学会秋期臨床大会
  • Place of Presentation: 千葉
• [Presentation] 健常者における1秒量の経年変化とNrf2遺伝子多型の検討 (2011)
  • Author(s): 増子裕典, 等
  • Organizer: 第23回日本アレルギー学会秋期臨床大会
  • Place of Presentation: 千葉
• [Presentation] 健常成人の呼吸機能におけるTSLP遺伝子多型の検討 (2010)
  • Author(s): 増子裕典
  • Organizer: 第60回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-11-27
• [Presentation] 健常成人の呼吸機能におけるTSLP遺伝子多型の検討 (2010)
  • Author(s): 増子裕典(代表)、坂本透、他6名
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] 血清総IgE 値、吸入抗原特異的IgE 抗体(MAST)を用いた感作パターンの解析 (2010)
  • Author(s): 飯島弘晃(代表)、坂本透、他6名
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] Decreased pre-bronchodilator FEV1 as a potential risk factor for COPD. (2010)
  • Author(s): Masuko H.(代表)、坂本透、他13名
  • Organizer: 106th International Conference of American Thoracic Society
  • Place of Presentation: The Convention Center (New Orleans, USA)
  • Year and Date: 2010-05-14
• [Presentation] 1秒率正常者における%1秒量の意義について (2010)
  • Author(s): 増子裕典
  • Organizer: 第50回日本呼吸器学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-24
• [Presentation] 1秒率正常者における%1秒量の意義について (2010)
  • Author(s): 増子裕典(代表)、坂本透、他4名
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-04-23