| Project/Area Number |
22590836
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
OHNO Yasushi 岐阜大学, 医学系研究科, 助教 (00334938)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MINATOGUCHI Shinya 岐阜大学, 医学系研究科, 教授 (20190697)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | COPD / エリスロポイエチン / 再生医学 / 肺気腫 / 酸化ストレス / 呼吸機能の評価 / HRCT検査 / エリスポエチン / 再生医療 |
|---|
| Research Abstract |
We made COPD model rabbit by elastase inhalation. As a result, the pulmonary emphysema-like change of the lungs of the human COPD resemblance. It enforced the Tetomilast dosage to provide PD4 inhibition having an antioxidant action as treatment orally. The progress to a pulmonary emphysema-like change was controlled by the evaluation four weeks later. In addition, the restraint of the aggravation of the restraint breathing function of the oxidation stress.
|
