• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapeutic approach for respiratory diseases targeting TRP genes

Research Project

Project/Area Number 22590837
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNagoya University

Principal Investigator

ITO Satoru  名古屋大学, 医学部附属病院, 助教 (60378073)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Yoshinori  名古屋大学, 大学院・医学系研究科, 教授 (20270986)
SATO Mitsuo  名古屋大学, 大学院・医学系研究科, 講師 (70467281)
Co-Investigator(Renkei-kenkyūsha) SOKABE Masahiro  名古屋大学, 大学院・医学系研究科, 教授 (10093428)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsTRP / STIM1 / Orai1 / 気道平滑筋 / 気管支喘息 / COPD / メカニカルストレス / 血管内皮 / カルシウムイオン / 気道平滑筋細胞 / cAMP / 呼吸生理学 / TRPチャネル / カルシウムチャネル / メカノトランスダクション / 肺微小血管内皮 / ARDS / STIM-1
Research Abstract

We demonstrated that Ca^2+influx mediated by activation of STIM1/Orai1 regulates migration of human airway smooth muscle cells. In contrast to cytosolic Ca^2+mobilization, elevation of cAMP levels inhibits proliferation and migration of airway smooth muscle cells. Excessive elevation of intracellular Ca^2+concentrations may contribute to the pathophysiology of asthma and COPD via altering cellular functions and phenotypes of pulmonary cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 13 results) Presentation (23 results) (of which Invited: 3 results) Book (4 results) Remarks (3 results)

  • [Journal Article] CAMP regulation of airway smooth muscle function2013

    • Author(s)
      Billington CK, Ojo OO, Penn RB, Ito S
    • Journal Title

      Pul Pharmacol Ther

      Volume: 26 Pages: 112-120

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of airway smooth muscle cell migration by prostanoid EP receptor subtypes.2013

    • Author(s)
      Aso H, Ito S, Mori A, Suganuma N, Morioka M, Takahara N, Kondo M, Hasegawa Y
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 48 Pages: 322-329

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞ストレスと呼吸器2013

    • Author(s)
      伊藤理
    • Journal Title

      呼吸

      Volume: 32 Pages: 192-202

    • Related Report
      2012 Final Research Report
  • [Journal Article] cAMP regulation of airway smooth muscle function.2013

    • Author(s)
      Billington CK, Ojo OO, Penn RB, Ito S.
    • Journal Title

      Pul Pharmacol Ther

      Volume: 26 Pages: 112-120

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 解説「基礎」呼吸器とメカニカルストレス2012

    • Author(s)
      伊藤理
    • Journal Title

      呼吸

      Volume: 31 Pages: 997-1004

    • Related Report
      2012 Final Research Report
  • [Journal Article] 細胞力覚:メカノセンシングが生命機能を生み出す: 呼吸器のメカノバイオロジー2012

    • Author(s)
      伊藤理、長谷川好規
    • Journal Title

      細胞工学

      Volume: 31 Pages: 1014-1029

    • Related Report
      2012 Final Research Report
  • [Journal Article] STIM1 regulates platelet-derived growth factor-induced migration and Ca^2+ influx in human airway smooth muscle cells2012

    • Author(s)
      Suganuma N, Ito S, Aso H, Kondo M, Sato M, Sokabe M, Hasegawa Y
    • Journal Title

      PLoS One

      Volume: 7:

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E_2 enhances IL-8 production via EP4 receptor in pulmonary microvascular endothelial cells.2012

    • Author(s)
      Aso H, Ito S, Mori A, Morioka M, Suganuma N, Kondo M, Imaizumi K, Hasegawa Y.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three cases of bronchial asthma preceding IgG4-related autoimmune pancreatitis2012

    • Author(s)
      Ito S, Ko SBH, Morioka M, Kondo M, Imaizumi K, Hasegawa Y
    • Journal Title

      Allergology Int

      Volume: 61 Pages: 171-174

    • NAID

      130004873035

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.2012

    • Author(s)
      Suganuma N, Ito S, Aso H, Kondo M, Sato M, Sokabe M, Hasegawa Y.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 enhances IL-8 production via EP4 receptor in pulmonary microvascular endothelial cells.2012

    • Author(s)
      Aso H, Ito S, Mori A, Morioka M, Suganuma N, Kondo M, Imaizumi K, Hasegawa Y.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells2012

    • Author(s)
      Aso H, et al
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells2011

    • Author(s)
      Morioka M, Parameswaran H, Naruse K, Kondo M, Sokabe M, Hasegawa Y, Suki B, Ito S
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of specific prostanoid EP receptor agonists on cell proliferation and intracellular Ca_2+concentrations in human airway smooth muscle cells2011

    • Author(s)
      Mori A, Ito S, Morioka M, Aso H, Kondo M, Sokabe M, Hasegawa Y
    • Journal Title

      Eur J Pharmacol

      Volume: 659 Pages: 72-78

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells2011

    • Author(s)
      Morioka M, et al
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of specific prostanoid EP receptor agonists on cell proliferation and intracellular Ca^<2+> concentrations in human airway smooth muscle cells.2011

    • Author(s)
      Mori A, Ito S, et. al.
    • Journal Title

      Eur J Pharmacol

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム8:気道平滑筋の収縮性変化が及ぼす病態とその機序2012

    • Author(s)
      伊藤理
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪 国際会議場
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] cAMP によるヒト気道平滑筋遊走能の制御機構2012

    • Author(s)
      伊藤理、麻生裕紀、菅沼伸一、高原紀博、森明美、近藤征史、長谷川好規
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪 国際会議場
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞ストレスと呼吸器2012

    • Author(s)
      伊藤理
    • Organizer
      第40回箱根呼吸器討論会
    • Place of Presentation
      大津 ロイヤルオークホテル
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] STIM1 regulates Ca^2+influx and migration induced by platelet-derived growth factor in human airway smooth muscle cells2012

    • Author(s)
      Ito S, Suganuma N, Aso H, Kondo M, Sato M, Hasegawa Y.
    • Organizer
      ATS 2012 International Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] オーガナイズドセッション:呼吸器とメカノバイオロジー2012

    • Author(s)
      伊藤理、長谷川好規
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡 国際会議場
    • Year and Date
      2012-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Symposium: Role of STIM-1 in regulation of airway smooth muscle functions2011

    • Author(s)
      Ito S, Suganuma N, Hasegawa Y
    • Organizer
      International Symposium on Mechanobiology
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of STIM1 in regulation of airway smooth muscle functions2011

    • Author(s)
      Ito S, et al
    • Organizer
      International Symposium on Mechanobiology
    • Place of Presentation
      中国・上海市(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト気道平滑筋細胞機能におけるSTIM1/ORAI1を介したstore-operated Ca2+流入の役割2011

    • Author(s)
      伊藤理, 他
    • Organizer
      第2回名古屋大学医学系研究科生理学研究所合同シンポジウム
    • Place of Presentation
      名古屋大学医学部附属病院
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト気道平滑筋細胞におけるSTIM-1によるstore-operated Ca2+ entryおよび遊走能の制御機構2011

    • Author(s)
      伊藤理, 他
    • Organizer
      第7回TRPチャネル研究会
    • Place of Presentation
      国立自然科学研究機構(愛知県岡崎市)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Essential role for microtubule dynamics in cyclic stretch-induced cell alignment in human airway smooth muscle cells2011

    • Author(s)
      Ito S, Parameswaran H, Morioka M, Naruse K, Kondo M, Sokabe M, Suki B, Hasegawa Y
    • Organizer
      ATS 2011 International Conference
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2011-05-16
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Regulation of cell proliferation and intracellular Ca^2+ concentrations by prostanoid EP receptor subtypes in human airway smooth muscle cells2011

    • Author(s)
      Ito S, Mori A, Hasegawa Y
    • Organizer
      7th Young Investigators' Meeting on Smooth Muscle
    • Place of Presentation
      Winnipeg, Canada
    • Year and Date
      2011-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] オーガナイズドセッション:呼吸器とメカニカルストレス2011

    • Author(s)
      伊藤理、長谷川好規
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電気大学神田キャンパス
    • Year and Date
      2011-04-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 呼吸器とメカニカルストレス2011

    • Author(s)
      伊藤理, 他
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学(東京都)(招待講演)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] STIM-1によるヒト気道平滑筋細胞のCa^<2+>シグナル制御機構2010

    • Author(s)
      伊藤理, 他
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 呼吸器系における細胞機能・病態生理とメカニカルストレス2010

    • Author(s)
      伊藤理, 他
    • Organizer
      メカノメディスンシンポジウム
    • Place of Presentation
      岡山大学(岡山)(招待講演)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト肺微小血管内皮細胞におけるストレッチ刺激によるIL-8産生の機序2010

    • Author(s)
      伊藤理, 他
    • Organizer
      名古屋大学・生理学研究所合同シンポジウム
    • Place of Presentation
      国立自然科学研究機構(愛知県岡崎市)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of stretch-activated Ca^<2+> channels in pulmonary cell mechanotransduction2010

    • Author(s)
      Ito S, et. al.
    • Organizer
      6^<th> World Congress on Biomechanics
    • Place of Presentation
      Singapore Suntec Convention Centre(Singapore)(招待講演)
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト肺微小血管内皮細胞におけるstretch-activated Ca^<2+> channelの制御とTRPVの関与について2010

    • Author(s)
      伊藤理, 他
    • Organizer
      第6回TRPチャネル研究会
    • Place of Presentation
      国立自然科学研究機構(愛知県岡崎市)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム8:気道平滑筋の収縮性変化が及ぼす病態とその機序.

    • Author(s)
      伊藤理.
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪 国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞ストレスと呼吸器.

    • Author(s)
      伊藤理.
    • Organizer
      第40回箱根呼吸器討論会
    • Place of Presentation
      大津 ロイヤルオークホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オーガナイズドセッション:呼吸器とメカノバイオロジー.

    • Author(s)
      伊藤理、長谷川好規.
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡 国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] STIM1 regulates Ca2+ influx and migration induced by platelet-derived growth factor in human airway smooth muscle cells.

    • Author(s)
      Ito S, Suganuma N, Aso H, Kondo M, Sato M, Hasegawa Y.
    • Organizer
      ATS 2012 International Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] cAMPによるヒト気道平滑筋遊走能の制御機構.

    • Author(s)
      伊藤理、麻生裕紀、菅沼伸一、高原紀博、森明美、近藤征史、長谷川好規.
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪 国際会議場
    • Related Report
      2012 Annual Research Report
  • [Book] Mechanical stretch and cytokine synthesis in pulmonary endothelial cells. In: Kamkin A, Kiseleva I (Eds) "Mechanosensitivity in cells and tissues" No 5. Mechanical stretch and cytokines.2012

    • Author(s)
      Ito S, Hasegawa Y
    • Publisher
      Springer, New York
    • Related Report
      2012 Final Research Report
  • [Book] Role of store-operated Ca^2+entry in airway smooth muscle cell functions and in pulmonary medicine. In: "Recent Advances in Mechanobiology".2012

    • Author(s)
      Ito S, Suganuma N, Hasegawa Y
    • Publisher
      Shanghai Scientific and Technological Literature Publishing House
    • Related Report
      2012 Final Research Report
  • [Book] Mechanical stretch and cytokine synthesis in pulmonary endothelial cells. In: Kamkin A, Kiseleva I (Eds) “Mechanosensitivity in cells and tissues” No 5. Mechanical stretch and cytokines.2012

    • Author(s)
      Ito S, Hasegawa Y.
    • Total Pages
      236
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] Mechanical stretch and cytokine synthesis in pulmonary endothelial cells. In : "Mechanosensitivity in cells and tissues" No 5. Mechanical stretch and cytokines(Kamkin A, Kiseleva I (Eds))2012

    • Author(s)
      Ito S, Hasegawa Y
    • Publisher
      Springer, New York, KY, USA
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med-nagoya-respmed.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/medical/1639/1674/kokyuukinaikagaku.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/medical/1639/1674/kokyukinaikagaku.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi