| Project/Area Number |
22590837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Satoru 名古屋大学, 医学部附属病院, 助教 (60378073)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yoshinori 名古屋大学, 大学院・医学系研究科, 教授 (20270986)
SATO Mitsuo 名古屋大学, 大学院・医学系研究科, 講師 (70467281)
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| Co-Investigator(Renkei-kenkyūsha) |
SOKABE Masahiro 名古屋大学, 大学院・医学系研究科, 教授 (10093428)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | TRP / STIM1 / Orai1 / 気道平滑筋 / 気管支喘息 / COPD / メカニカルストレス / 血管内皮 / カルシウムイオン / 気道平滑筋細胞 / cAMP / 呼吸生理学 / TRPチャネル / カルシウムチャネル / メカノトランスダクション / 肺微小血管内皮 / ARDS / STIM-1 |
|---|
| Research Abstract |
We demonstrated that Ca^2+influx mediated by activation of STIM1/Orai1 regulates migration of human airway smooth muscle cells. In contrast to cytosolic Ca^2+mobilization, elevation of cAMP levels inhibits proliferation and migration of airway smooth muscle cells. Excessive elevation of intracellular Ca^2+concentrations may contribute to the pathophysiology of asthma and COPD via altering cellular functions and phenotypes of pulmonary cells.
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