| Project/Area Number |
22590841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSE Hiroto 長崎大学, 医歯薬学総合研究科, 准教授 (60336154)
KOHNO Shigeru 長崎大学, 医歯薬学総合研究科, 准教授 (80136647)
KAWANO Tetsuya 長崎大学, 大学病院, 助教 (50457511)
TSUCHIDA Tomoko 長崎大学, 大学病院, 助教 (60581949)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 気管支喘息 / 真菌 / アレルギー / アスペルギルス / 抗真菌薬 / マクロライド系抗菌薬 / ダニ / 感作 / アレルギー性炎症 / サイトカイン |
|---|
| Research Abstract |
Dermatophagoides farina (Df) allergen sensitization in the mice concomitant with Aspergillus fumigatus (Af) administration enhanced Th2 cytokine andMUC5ac production in the airway and caused the exacerbation of allergic asthma. Thatallergic inflammation was more severe than that of Af sensitized mice concomitant withAf administration. Df allergen-induced allergic airway inflammation decreased phagocytic activities of alveolar macrophages, which permitted Af to colonize in the allergic airways.Combinations with corticosteroid and other drugs such as antifungal drugs decreased allergic inflammation. The combination with corticosteroid and macrolides was the most effective in decreasing allergic inflammations in our experiments.
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