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Development of the treatment of mucus overproduction in COPD using an animal model of elastase-induced goblet cell metaplasia

Research Project

Project/Area Number 22590844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

KONDO Mitsuko  東京女子医科大学, 医学部, 講師 (50178430)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエラスターゼ / 杯細胞化生 / ムスカリン受容体 / チオトロピウム / COPD / MUC5AC / フォスフォジエステラーゼ4 / 細胞内カルシウム / 気道炎症
Research Abstract

Airway occlusion by mucus in COPD is associated with a poor prognosis. Repeated-elastase aspiration induced marked goblet cell metaplasia in mice. The goblet cell metaplasia, increase in inflammatory cells and chemokine levels in BALF, M3receptor expression, MUC5AC production in vitro were inhibited by tiotropium. This result suggests that tiotropium may be useful for the treatment of mucus overproduction by anti-inflammatory action and a direct action on epithelial cells

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Niflumic Acid Inhibits Goblet Cell Degranulation in a Guinea Pig Asthma Model2012

    • Author(s)
      Kondo M., Nakata J., Arai N., Izumo T., Tagaya E., Takeyama K., Tamaoki J., Nagai A
    • Journal Title

      Allergology International

      Volume: 61 Issue: 1 Pages: 133-142

    • DOI

      10.2332/allergolint.11-OA-0307

    • NAID

      130004873030

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 医学と医療の最前線気道分泌の管理と治療2012

    • Author(s)
      近藤光子 玉置淳
    • Journal Title

      日本内科学会誌

      Volume: Dec 10, 101(12) Pages: 3525-32

    • Related Report
      2012 Final Research Report
  • [Journal Article] 喘息治療の薬理遺伝学2012

    • Author(s)
      近藤光子 玉置淳
    • Journal Title

      最新医学

      Volume: 67(6)

    • Related Report
      2012 Final Research Report
  • [Journal Article] 慢性気道炎症とマクロライド療法2012

    • Author(s)
      近藤光子
    • Journal Title

      日本胸部臨床

      Volume: 71 (1) Pages: 29-37

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 医療と医学の最前線 気道分泌の管理と治療2012

    • Author(s)
      近藤光子
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 3525-3532

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 喘息治療の薬理遺伝学2012

    • Author(s)
      近藤光子
    • Journal Title

      最新医学

      Volume: 67 Pages: 84-89

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma model2012

    • Author(s)
      Mitsuko Kondo
    • Journal Title

      Allergology International

      Volume: (In press)

    • NAID

      130004873030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痰を伴う咳2011

    • Author(s)
      近藤光子
    • Journal Title

      診断と治療

      Volume: 99 (12) Pages: 2037-2049

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice.2010

    • Author(s)
      Arai N., Kondo M., Izumo T., Tamaoki J., Nagai A.
    • Journal Title

      Eur Respir J.

      Volume: 35 Issue: 5 Pages: 1164-1171

    • DOI

      10.1183/09031936.00040709

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of leukotoriene B4 receptor antagonist in pulmonary fibrosis2010

    • Author(s)
      Izumo T., Kondo M., Arai N., Nagai A.
    • Journal Title

      Annals of Respiratory Medicine

      Volume: 1(2) Pages: 1-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparable effect of a leukotriene receptor antagonist and long-acting beta2-adrenergic agonist in cough variant asthma.2010

    • Author(s)
      Tamaoki J., Yokohori N., Tagaya E., Kirishi S., Miyamoto Y., Ochiai K., KondoM., Nagai A.
    • Journal Title

      Allergy Asthma Proc.

      Volume: Sep-Oct; 31(5) Issue: 5 Pages: 78-84

    • DOI

      10.2500/aap.2010.31.3366

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ウイルス感染と気道炎症の増悪(2) COPDはなぜ悪化するのか2010

    • Author(s)
      近藤光子
    • Journal Title

      The Lung perspectives

      Volume: 18巻4号

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice2010

    • Author(s)
      Arai N., Kondo M., et al
    • Journal Title

      Eur Respir J

      Volume: 35 Pages: 1164-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ウイルス感染と気道炎症の増悪(2)-COPDはなぜ悪化するのか2010

    • Author(s)
      近藤光子
    • Journal Title

      The Lung perspectives

      Volume: 14 Pages: 358-361

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 喘息とCOPDの合併/境界例の治療2010

    • Author(s)
      近藤光子
    • Journal Title

      呼吸器内科

      Volume: 18 Pages: 240-246

    • Related Report
      2010 Annual Research Report
  • [Presentation] 厚生労働科学研究費補助金難治性疾患克服研究事業 呼吸不全に関する調査研究班2012

    • Author(s)
      近藤光子 玉置淳
    • Organizer
      平成 24 年度第2回総会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Niflumic acid inhibits antigen- and histamine-induced goblet cell degranulation in a guinea pig asthma model2012

    • Author(s)
      Kondo M., Nakata J., Nagara N., Takeyama K., Tagaya E., Tamaoki J., Nagai A.
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] モルモット喘息モデルにおけるヒスタミン誘起性気道分泌反応に対する Niflumic acid の抑制効果2011

    • Author(s)
      近藤光子 中田潤子 新井尚希 多賀谷悦子 玉置淳 永井厚志
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 気腔から肺胞までの粘膜病態 one airway one disease2011

    • Author(s)
      近藤光子 洲崎春海
    • Organizer
      第51回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 気腔から肺胞までの粘膜病態one airway one disease座長のことば2011

    • Author(s)
      近藤光子
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] The frequency of gastroesophageal reflux disease and the therapeutic effect of rabeprazole in patients2010

    • Author(s)
      Kondo M., Nagaoka M., Nakata J., IzumoT., Arai N., Tamaoki J., Nagai A.
    • Organizer
      asthma European Respiratory Society Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Niflumic acid inhibits antigen- and histamine-induced goblet cell degranulation in a guinea pig asthma model.

    • Author(s)
      Mitsuko Kondo
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] COPD随伴症状としての慢性咳嗽および気道過分泌の病態に関する研究

    • Author(s)
      近藤光子
    • Organizer
      厚生労働科学研究費補助金難治性疾患克服研究事業 呼吸不全に関する調査研究班 平成24年度第2回総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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