| Project/Area Number |
22590845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KIDA Kozui 日本医科大学, 医学部, 教授 (90142645)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Takeo 日本医科大学, 医学部, 講師 (90445750)
MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
SAWABE Motoji 東京医科歯科大学, その他の研究科, 教授 (30196331)
MIENO Makiko 自治医科大学, 医学部, 助教 (60464707)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Tomio 地方独立行政法人東京都健康長寿医療セ ンター(東京都健康長寿医療センター研究所), 研究員 (20232019)
IKEDA Shinobu 東京医科歯科大学, 難治疾患研究所, 助教 (20415508)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 閉塞性肺疾患 / 喫煙 / 肺気腫 / ニコチン受容体 / 遺伝子多型 / COPD / 肺癌 / 肺線維症 |
|---|
| Research Abstract |
The study population comprised 366 current or ex-smokers including 247 COPD patients. Two of the SNPs, rs3743078 and rs660652, in CHRNB4-CHRNA3-CHRNA5 showed an association with %LAA in the upper region of the lungs (p = 0.0050 and 0.0038, respectively) and were also associated with the mRNA expression of CHRNA3 and CHRNA5. CHRNA3 was expressed also in the lung, confirmed pathologically.
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