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The association between genetic variations of the neuronal nicotinic cholinergic receptors and smoking-related lung diseases

Research Project

Project/Area Number 22590845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

KIDA Kozui  日本医科大学, 医学部, 教授 (90142645)

Co-Investigator(Kenkyū-buntansha) ISHII Takeo  日本医科大学, 医学部, 講師 (90445750)
MURAMATSU Masaaki  東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
SAWABE Motoji  東京医科歯科大学, その他の研究科, 教授 (30196331)
MIENO Makiko  自治医科大学, 医学部, 助教 (60464707)
Co-Investigator(Renkei-kenkyūsha) ARAI Tomio  地方独立行政法人東京都健康長寿医療セ ンター(東京都健康長寿医療センター研究所), 研究員 (20232019)
IKEDA Shinobu  東京医科歯科大学, 難治疾患研究所, 助教 (20415508)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords閉塞性肺疾患 / 喫煙 / 肺気腫 / ニコチン受容体 / 遺伝子多型 / COPD / 肺癌 / 肺線維症
Research Abstract

The study population comprised 366 current or ex-smokers including 247 COPD patients. Two of the SNPs, rs3743078 and rs660652, in CHRNB4-CHRNA3-CHRNA5 showed an association with %LAA in the upper region of the lungs (p = 0.0050 and 0.0038, respectively) and were also associated with the mRNA expression of CHRNA3 and CHRNA5. CHRNA3 was expressed also in the lung, confirmed pathologically.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2011

All Presentation (2 results)

  • [Presentation] Association between emphysema and genetic variations of CHRNA32011

    • Author(s)
      Takeo Ishii, Kozui Kida, 他
    • Organizer
      American Thoracic Society 2011 International Conference
    • Place of Presentation
      デンバー(アメリカ)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association between emphysema and genetic variations of CHRNA32011

    • Author(s)
      Takeo Ishii, Kozui Kida 他
    • Organizer
      American Thoracic Society 2011 International Conference
    • Place of Presentation
      デ ンバー(アメリカ)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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