Analysis of individual difference of an epidermal growth factor receptor downstream signal system
| Project/Area Number |
22590850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
SAKAIDA Emiko 千葉大学, 医学部附属病院, 助教 (60422218)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGUCHI Yuichi 千葉大学, 大学院・医学研究院, 教授 (30272321)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Yuji 千葉大学, 医学部附属病院, 助教 (50344990)
KUROSU Katsushi 千葉大学, 医学部附属病院, 講師 (20291106)
TANABE Nobuhiro 千葉大学, 大学院・医学研究院, 准教授 (40292700)
TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 非閉塞性肺疾患 / 腫瘍学 |
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| Research Abstract |
The purpose is to examine the role of a downstream signal system of EGFR in detail for clarifying factors other than the EGFR gene variation which determines the susceptibility of the medicine, and considering existence of the hereditary individual difference of the course. We planned clinical trial which prescribes erlotinib for the patient as second line treatment for a non-small-cell-lung-cancer case with a wild type EGFR gene, and performingbiomarker search by a cDNA microarray and RT-PCR.It checked that RNA extraction of the high purity of a tumor was possible from the minute biopsy sample of puncture under the ultrasound endoscopy (EBUS), and established the method of conducting DNA microarray analysis efficiently from a clinical sample. Furthermore, fundamental study was performed using the non-small-cell-lung-cancer-cells and mesothelioma-cells stock for the purpose of clarifying biological significance relevant to the effect of Erlotinib. Thymidylate synthase expression did not necessarily correlate with pemetrexed resistance. Metformin inhibited the proliferation of various histological types of human lung cancer cell lines, possibly by varied mechanisms including apoptosis induction and G0/G1 arrest according to the cell line.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed.2012
Author(s)
Li, Q., Kawamura, K., Okamoto, S., Yamanaka, M., Yang, S., Yamauchi, S., Fukamachi, T., Kobayashi, H., Tada, Y., Takiguchi, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
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Journal Title
Cancer Gene Ther.
Volume: 19
Pages: 218-228
DOI
Related Report
Peer Reviewed
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[Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema.2012
Author(s)
Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
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Journal Title
American Journal Of Physiology. Lung Cellular And Molecular Physiology
Volume: 303
Pages: 141-151
DOI
Related Report
Peer Reviewed
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[Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma2011
Author(s)
Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F
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Journal Title
Cancer Science
Volume: 102
Pages: 1366-1373
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Phase I/II trial of gemcitabine plus oral TS-1 in elderly patients with advanced non-small cell lung cancer: Thoracic oncology research group study 05022010
Author(s)
Seto T, Yamanaka T, Wasada I, Seki N, Okamoto H, Ogura T, Shibuya M, Takiguchi Y, Shinkai T, Masuda N, et al
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Journal Title
DOI
Related Report
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[Journal Article] Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer2010
Author(s)
Takiguchi Y, Tada Y, Gemma A, Kudoh S, Hino M, Yoshimori K, Yoshimura A, Nagao K, Niitani H
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Journal Title
Lung Cancer
Volume: 68(3)
Pages: 409-14
DOI
Related Report
Peer Reviewed
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[Presentation] Interaction andcross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines2012
Author(s)
Miyako Kitazono, Yuichi Takiguchi, Satoru Kitazono, Hironori Ashinuma, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Nobuhiro Tanabe, Masatoshi Tagawa, Koichiro Tatsumi
Organizer
American Association for Cancer Research 2012 Annual Meeting
Place of Presentation
Chicago, IL. USA
Related Report
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[Presentation] Anti-proliferative action of metformin on various types of human lung cancer cell lines2012
Author(s)
Hironori Ashinuma, Yuichi Takiguchi,Satoru Kitazono, Miyako Kitazono-Saitoh, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Nobuhiro Tanabe, Koichiro Tatsumi
Organizer
American Association for Cancer Research 2012 Annual Meeting
Place of Presentation
Chicago, IL. USA
Related Report
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[Presentation] Effects of metformin on a non-small cell lung cancer cell line with an EGFR mutation2012
Author(s)
Satoru Kitazono, Yuichi Takiguchi, Hironori Ashinuma, Miyako Kitazono, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Koichiro Tatsumi
Organizer
American Association for Cancer Research 2012Annual Meeting
Place of Presentation
Chicago, IL. USA
Related Report
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