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Analysis of individual difference of an epidermal growth factor receptor downstream signal system

Research Project

Project/Area Number 22590850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

SAKAIDA Emiko  千葉大学, 医学部附属病院, 助教 (60422218)

Co-Investigator(Kenkyū-buntansha) TAKIGUCHI Yuichi  千葉大学, 大学院・医学研究院, 教授 (30272321)
Co-Investigator(Renkei-kenkyūsha) TADA Yuji  千葉大学, 医学部附属病院, 助教 (50344990)
KUROSU Katsushi  千葉大学, 医学部附属病院, 講師 (20291106)
TANABE Nobuhiro  千葉大学, 大学院・医学研究院, 准教授 (40292700)
TATSUMI Koichiro  千葉大学, 大学院・医学研究院, 教授 (10207061)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 非閉塞性肺疾患 / 腫瘍学
Research Abstract

The purpose is to examine the role of a downstream signal system of EGFR in detail for clarifying factors other than the EGFR gene variation which determines the susceptibility of the medicine, and considering existence of the hereditary individual difference of the course. We planned clinical trial which prescribes erlotinib for the patient as second line treatment for a non-small-cell-lung-cancer case with a wild type EGFR gene, and performingbiomarker search by a cDNA microarray and RT-PCR.It checked that RNA extraction of the high purity of a tumor was possible from the minute biopsy sample of puncture under the ultrasound endoscopy (EBUS), and established the method of conducting DNA microarray analysis efficiently from a clinical sample. Furthermore, fundamental study was performed using the non-small-cell-lung-cancer-cells and mesothelioma-cells stock for the purpose of clarifying biological significance relevant to the effect of Erlotinib. Thymidylate synthase expression did not necessarily correlate with pemetrexed resistance. Metformin inhibited the proliferation of various histological types of human lung cancer cell lines, possibly by varied mechanisms including apoptosis induction and G0/G1 arrest according to the cell line.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010

All Journal Article (32 results) (of which Peer Reviewed: 21 results) Presentation (6 results)

  • [Journal Article] Antiproliferative action of metformin in human lung cancer cell lines2012

    • Author(s)
      Ashinuma H, Takiguchi Y, Sakaida E, Sekine I, et al
    • Journal Title

      Oncology Reports

      Volume: 28(1) Pages: 8-14

    • DOI

      10.3892/or.2012.1763

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction and cross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines2012

    • Author(s)
      Kitazono-Saitoh M, Takiguchi Y, Sakaida E, Sekine I, Tanabe N, et al
    • Journal Title

      Oncology Reports

      Volume: 28(1) Pages: 33-40

    • DOI

      10.3892/or.2012.1799

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a learning system for endobronchial ultrasound-guided transbronchial needle aspiration2012

    • Author(s)
      Sakairi Y, Saegusa F, Takiguchi Y, Tatsumi K, Yoshino I, et al
    • Journal Title

      Respiratory Investigation

      Volume: 50(2) Pages: 46-53

    • Related Report
      2012 Final Research Report
  • [Journal Article] Feasibility of cytological diagnosis of sarcoidosis with endobronchial US-guided transbronchial aspiration2012

    • Author(s)
      Kitamura A, Takiguchi Y, Kurosu K, Tanabe N, Nakatani Y, Yoshino I, et al
    • Journal Title

      Sarcoidosis, Vasculitis, And Diffuse Lung Diseases: Official Journal Of WASOG / World Association Of Sarcoidosis And Other Granulomatous Disorders

      Volume: 29(2) Pages: 82-89

    • Related Report
      2012 Final Research Report
  • [Journal Article] A case report of mediastinal seminoma arising after renal transplantation2012

    • Author(s)
      Anzai M, Kenmochi T, Takiguchi Y, Matsumura C, Kanemoto K, et al
    • Journal Title

      CEN Case Rep

      Volume: 1 Pages: 90-95

    • Related Report
      2012 Final Research Report
  • [Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed2012

    • Author(s)
      Li, Q., Kawamura, K., Okamoto, S., Yamanaka, M., Yang, S., Yamauchi, S., Fukamachi, T., Kobayashi, H., Tada, Y., Takiguchi, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
    • Journal Title

      Cancer Gene Ther

      Volume: 19 Issue: 3 Pages: 218-228

    • DOI

      10.1038/cgt.2011.86

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumorsfails to induce apoptosis or produce anti-tumor effects2012

    • Author(s)
      Nagakawa H, Shimozato O, Tada Y, Takiguchi Y, Tatsumi K, et al
    • Journal Title

      Cellular Immunology

      Volume: 275(1-2) Issue: 2 Pages: 90-97

    • DOI

      10.1016/j.resinv.2012.04.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema2012

    • Author(s)
      Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
    • Journal Title

      American Journal of Physiology

      Volume: 303 Issue: 2 Pages: 141-151

    • DOI

      10.1152/ajplung.00337.2011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction and cross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines.2012

    • Author(s)
      Kitazono-Saitoh M, et al
    • Journal Title

      Oncol Rep

      Volume: 28(1) Pages: 33-40

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma2011

    • Author(s)
      Iwasawa S, Yamano Y, Takiguchi Y, Tanzawa H, Tatsumi K, Uzawa K
    • Journal Title

      Oncology Reports

      Volume: 25(3) Issue: 3 Pages: 637-644

    • DOI

      10.3892/or.2010.1131

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in treatment of malignant pleural mesothelioma2011

    • Author(s)
      Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 7 Pages: 1366-73

    • DOI

      10.1111/j.1349-7006.2011.01931.x

    • NAID

      10029295478

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhalation of Stachybotrys chartarum Evokes Pulmonary Arterial Remodeling in Mice,Attenuated by Rho-KinaseInhibitor2011

    • Author(s)
      Nagayoshi M, Tada Y, West J, Tanabe N, Takiguchi Y, Yasuda T, et al
    • Journal Title

      Mycopathologia

      Volume: 172(1) Pages: 5-15

    • Related Report
      2012 Final Research Report
  • [Journal Article] An early event of EGFR mutation in pleomorphic carcinoma of the lung2011

    • Author(s)
      Saitoh M, Niijima M, Takiguchi Y, Hiroshima K, Tatsumi K
    • Journal Title

      International Journal Of Clinical Oncology / Japan Society Of Clinical Oncology

      Volume: 16(6) Pages: 770-773

    • NAID

      10030247775

    • Related Report
      2012 Final Research Report
  • [Journal Article] Risk of acute exacerbation of interstitial pneumonia after pulmonary resection for lung cancer in patients with idiopathic pulmonary fibrosis based on preoperative high-resolution computed tomography2011

    • Author(s)
      Suzuki H, Sekine Y, Mizuno S, Takiguchi Y, et al
    • Journal Title

      Surgery Today

      Volume: 41(7) Pages: 914-921

    • NAID

      10029048516

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pushing an old issue towards a new front line2011

    • Author(s)
      Takiguchi Y
    • Journal Title

      Japanese Journal Of Clinical Oncology

      Volume: 41(8) Pages: 935-936

    • Related Report
      2012 Final Research Report
  • [Journal Article] Long-term administration of second-line chemotherapy with S-1 and gemcitabine for platinum-resistant non-small cell lung cancer: a phase II study2011

    • Author(s)
      Takiguchi Y, Seto T, Ichinose Y, , Minato K, Seki N, Eguchi K, Kishi K, et al
    • Journal Title

      Journal Of Thoracic Oncology: Official Publication Of The International Association For The Study Of Lung Cancer

      Volume: 6(1) Pages: 156-160

    • Related Report
      2012 Final Research Report
  • [Journal Article] Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells2011

    • Author(s)
      Yamano Y, et al
    • Journal Title

      Head & Neck

      Volume: 33(3) Issue: 3 Pages: 309-317

    • DOI

      10.1002/hed.21445

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term administration of second-line chemotherapy with S-1 and gemcitabine for platinum-resistant non-small cell lung cancer: A phase II study2011

    • Author(s)
      Takiguchi Y, et al
    • Journal Title

      Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

      Volume: 6 Issue: 1 Pages: 156

    • DOI

      10.1097/jto.0b013e3181f7c76a

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACTH deficiency and PGI(2) therapy in chronic thromboembolic pulmonary hypertension2011

    • Author(s)
      Ikari J, et al
    • Journal Title

      International Journal Of Cardiology

      Volume: 146(3) Issue: 3 Pages: 449-450

    • DOI

      10.1016/j.ijcard.2010.10.115

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term administration of second-line chemotherapy with S-1 and gemcitabine for platinum-resistant non-small cell lung cancer : a phase II study.2011

    • Author(s)
      Takiguchi Y, et al
    • Journal Title

      Journal of Thoracic Oncology : Official Publication of The International Association For The Study of Lung Cancer

      Volume: 6(1) Pages: 156-160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.2011

    • Author(s)
      Iwasawa S, et al
    • Journal Title

      Oncology Reports

      Volume: 25(3) Pages: 637-644

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACTH deficiency and PGI(2) therapy in chronic thromboembolic pulmonary hypertension.2011

    • Author(s)
      Ikari J, et al
    • Journal Title

      International Journal of Cardiology

      Volume: 146(3) Pages: 449-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation pneumonitis following twice-daily radiotherapy with concurrent carboplatin and paclitaxel in patients with stage III non-small-cell lung cancer2010

    • Author(s)
      Kobayashi H, Uno T, Isobe K, Ueno N, Watanabe M, Harada R, Takiguchi Y, Tatsumi K, Ito H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40(5) Issue: 5 Pages: 464-469

    • DOI

      10.1093/jjco/hyp190

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Phase I/II trial of gemcitabine plus oral TS-1 in elderly patients with advanced non-small cell lung cancer: Thoracic oncology research group study 05022010

    • Author(s)
      Seto T, Yamanaka T, Wasada I, Seki N, Okamoto H, Ogura T, Shibuya M, Takiguchi Y, Shinkai T, Masuda N, et al
    • Journal Title

      Lung Cancer

      Volume: 69 Issue: 2 Pages: 213

    • DOI

      10.1016/j.lungcan.2009.10.017

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer2010

    • Author(s)
      Takiguchi Y, Tada Y, Gemma A, Kudoh S, Hino M, Yoshimori K, Yoshimura A, Nagao K, Niitani H
    • Journal Title

      Lung Cancer

      Volume: 68(3) Issue: 3 Pages: 409-14

    • DOI

      10.1016/j.lungcan.2009.08.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma2010

    • Author(s)
      Yamatoji M, et al
    • Journal Title

      Oncol Rep

      Volume: 23(1) Issue: 1 Pages: 61-7

    • DOI

      10.3892/or_00000606

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of perioperative administration of long-acting bronchodilator on postoperative pulmonary function and quality of life in lung cancer patients with chronic obstructive pulmonary disease. Preliminary results of a randomized control study2010

    • Author(s)
      Suzuki H, et al
    • Journal Title

      Surgery Today

      Volume: 40(10) Issue: 10 Pages: 923-930

    • DOI

      10.1007/s00595-009-4196-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer.2010

    • Author(s)
      Takiguchi Y, et al
    • Journal Title

      Lung Cancer

      Volume: 68(3) Pages: 409-414

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tanzawa H, Uzawa K (2010) State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma.2010

    • Author(s)
      Yamatoji M, et al
    • Journal Title

      Oncol Rep

      Volume: 23(1) Pages: 61-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of perioperative administration of long-acting bronchodilator on postoperative pulmonary function and quality of life in lung cancer patients with chronic obstructive pulmonary disease.Preliminary results of a randomized control study.2010

    • Author(s)
      Suzuki H, et al
    • Journal Title

      Surgery Today

      Volume: 40(10) Pages: 923-930

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase 1/11 trial of gemcitabine plus oral TS-1 in elderly patients with advanced-non-small cell lung cancer : Thoracic oncology research group study 0502.2010

    • Author(s)
      Seto T, et al
    • Journal Title

      Lung Cancer (Amsterdam, Netherlands)

      Volume: 69(2) Pages: 213-217

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation pneumonitis following twice-daily radiotherapy with concurrent carboplatin and paclitaxel in patients with stage III non-small-cell lung cancer.2010

    • Author(s)
      Kobayashi H, et al
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40(5) Pages: 464-469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Interaction andcross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines2012

    • Author(s)
      Miyako Kitazono, Yuichi Takiguchi, Satoru Kitazono, Hironori Ashinuma, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Nobuhiro Tanabe, Masatoshi Tagawa, Koichiro Tatsumi
    • Organizer
      American Association for Cancer Research 2012 Annual Meeting
    • Place of Presentation
      Chicago, IL. USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Anti-proliferative action of metformin on various types of human lung cancer cell lines2012

    • Author(s)
      Hironori Ashinuma, Yuichi Takiguchi,Satoru Kitazono, Miyako Kitazono-Saitoh, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Nobuhiro Tanabe, Koichiro Tatsumi
    • Organizer
      American Association for Cancer Research 2012 Annual Meeting
    • Place of Presentation
      Chicago, IL. USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of metformin on a non-small cell lung cancer cell line with an EGFR mutation2012

    • Author(s)
      Satoru Kitazono, Yuichi Takiguchi, Hironori Ashinuma, Miyako Kitazono, Atsushi Kitamura, Yuji Tada, Katsushi Kurosu, Emiko Sakaida, Ikuo Sekine, Koichiro Tatsumi
    • Organizer
      American Association for Cancer Research 2012Annual Meeting
    • Place of Presentation
      Chicago, IL. USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Interaction and cross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines2012

    • Author(s)
      Kitazono-Saitoh M et al
    • Organizer
      American Association for Cancer Research 2012 Annual Meeting.
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anti-proliferative action of metformin on various types of human lung cancer cell lines.2012

    • Author(s)
      Ashinuma H, et al
    • Organizer
      American Association for Cancer Research 2012 Annual Meeting.
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of metformin on a non-small cell lung cancer cell line with an EGFR mutation.2012

    • Author(s)
      Kitazono S et al
    • Organizer
      American Association for Cancer Research 2012 Annual Meeting.
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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