The study on administration route of T-cell independent vaccinefrom the point view of bronchus-associated lymphoid tissue

• Project/Area Number: 22590855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: CHIDA Kingo 浜松医科大学, 医学部, 准教授 (40197611)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 気管支随伴リンパ組織 / T 細胞非依存不活化ワクチン / 肺炎球菌莢膜多糖体ワクチン / 経鼻投与 / 肺局所免疫 / 肺炎球菌ワクチン / 皮下投与 / 気管支肺胞洗浄液 / T細胞非依存不活化ワクチン

Research Abstract

In order to enhance the efficacy of pneumococcal capsular polysaccharide vaccine (PPV), we compared the subcutaneous administration of PPV with intranasal route of PPV. Intranasal administration caused the induction of PPV -specific IgG antibody, but not subcutaneous vaccination.

Research Products

• [Journal Article] Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro． (2012)
  • Author(s): Suzuki Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46(6) Issue: 6 Pages: 773-780
  • DOI: 10.1165/rcmb.2011-0329oc
  • Peer Reviewed
• [Journal Article] Enhancement of protective immunity against intracellular bacteria using type-1 polarized dendritic cell (DC) vaccine (2012)
  • Author(s): Kono M
  • Journal Title: Vaccine Volume: 30 Issue: 16 Pages: 2633-2639
  • DOI: 10.1016/j.vaccine.2012.02.026
  • Peer Reviewed
• [Journal Article] Clinical characteristics and prognosis of chronic pulmonary aspergillosis． (2012)
  • Author(s): Ohba H
  • Journal Title: Respir Med Volume: 106(5) Issue: 5 Pages: 724-729
  • DOI: 10.1016/j.rmed.2012.01.014
  • Peer Reviewed
• [Journal Article] Impaired cough-related quality of life in patients with controlled asthma with gastroesophageal reflux disease． (2012)
  • Author(s): Shirai T
  • Journal Title: Ann Allergy Asthma Immunol Volume: 108(5) Pages: 379-380
  • Peer Reviewed
• [Journal Article] Expression and function of multidrug resistance protein 1 and multidrug resistance associated protein 1 in lung dendritic cells from aging mice． (2012)
  • Author(s): Inui N
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 67(10) Pages: 1049-1055
  • Peer Reviewed
• [Journal Article] Effect of Switching from Salmeterol/Fluticasone to Formoterol/ Budesonide Combinations in Patients with Uncontrolled Asthma (2012)
  • Author(s): Akamatsu T
  • Journal Title: Allergology International Volume: 61 Issue: 2 Pages: 323-329
  • DOI: 10.2332/allergolint.11-OA-0384
  • NAID: 130004477131
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation． (2012)
  • Author(s): Yasui H
  • Journal Title: Respir Med Volume: 106(4) Issue: 4 Pages: 508-514
  • DOI: 10.1016/j.rmed.2011.12.014
  • Peer Reviewed
• [Journal Article] Rheumatoid lung disease: Prognostic analysis of 54 biopsy-proven cases． (2012)
  • Author(s): Nakamura Y
  • Journal Title: Respir Med Volume: 106(8) Issue: 8 Pages: 1164-1169
  • DOI: 10.1016/j.rmed.2012.04.004
  • Peer Reviewed
• [Journal Article] Pulmonary dendritic cell accumulation in usual interstitial pneumonia and nonspecific interstitial pneumonia． (2012)
  • Author(s): Karayama M
  • Journal Title: Sarcoidosis Vasc Diffuse Lung Dis Volume: 29(1) Pages: 69-73
  • Peer Reviewed
• [Journal Article] Drug lymphocyte stimulation test is not useful for side effects of anti-tuberculosis drugs despite its timing． (2012)
  • Author(s): Miwa S
  • Journal Title: Int J Tuberc Lung Dis Volume: 16(9) Pages: 1265-1269
  • Peer Reviewed
• [Journal Article] Biweekly combination therapy with gemcitabine and carboplatin compared with gemcitabine monotherapy in elderly patients with advanced non-small-cell lung cancer: a randomized, phase-II study． (2012)
  • Author(s): Kusagaya H,
  • Journal Title: Lung Cancer Volume: 77(3) Pages: 550-555
  • Peer Reviewed
• [Journal Article] Idiopathic Pleuroparenchymal Fibroelastosis: Consideration of a clinicopathological entity in a series of Japanese patients. (2012)
  • Author(s): Kusagaya H,
  • Journal Title: BMC Pulm Med Volume: 12(1) Pages: 72-72
  • Peer Reviewed
• [Journal Article] Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells (2011)
  • Author(s): Kato M
  • Journal Title: Cancer Immunol Immunother Volume: 60(7) Issue: 7 Pages: 1029-1038
  • DOI: 10.1007/s00262-011-1015-5
  • Peer Reviewed
• [Journal Article] A novel vaccine strategy to induce mycobacterial antigen-specific Th1 Responses by utilizing the C-terminal domain of heat shock protein 70 (2011)
  • Author(s): K.Chida, et al
  • Journal Title: FEMS Immunol Med Microbiol Volume: 61 Issue: 2 Pages: 189-196
  • DOI: 10.1111/j.1574-695x.2010.00762.x
  • Peer Reviewed
• [Journal Article] Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF) (2011)
  • Author(s): Kono M, Nakamura Y, Suda T, Kato M, Kaida Y, Hashimoto D, Inui N, Hamada E, Miyazaki O, Kurashita S, Fukamachi I, Endo K, Ng P Takehara K, Nakamura H, Maekawa M, Chida K
  • Journal Title: Clinica Chimica Acta Volume: 412 Issue: 23-24 Pages: 2211-2215
  • DOI: 10.1016/j.cca.2011.08.008
  • Peer Reviewed
• [Journal Article] Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis. (2010)
  • Author(s): K. Chida, et al
  • Journal Title: Respir Med Volume: 104 Pages: 1210-1210
  • Peer Reviewed
• [Journal Article] Usefulness of serum procalcitonin levels in pulmonary tuberculosis. (2010)
  • Author(s): K. Chida, et al
  • Journal Title: Eur Respir J Volume: 37 Pages: 371-375
  • Peer Reviewed
• [Journal Article] Antiendothelial Cell Antibodies in Patient With COPD. (2010)
  • Author(s): K. Chida
  • Journal Title: Chest Volume: 138 Pages: 1303-1308
  • Peer Reviewed
• [Presentation] Ultrasonic microscope for imaging of fibrotic interstitial pneumonia． (2012)
  • Author(s): Nakamura Y
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Usefulness of Non-Invasive Positive Pressure Ventilation (NPPV) for acute exacerbation of asthma． (2012)
  • Author(s): Yasui H
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Association with peripheral airway inflammation and dysfunction． (2012)
  • Author(s): Shirai T
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Effect of switching from Salmeterol/Fluticasone to Formoterol/Budesonide combinations in patients with uncontrolled asthma． (2012)
  • Author(s): Akamatsu T
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Anti-IgE monoclonal antibody, Omalizumab, Is useful for the management of various phenotypes of severe asthma． (2012)
  • Author(s): Toyoshima M
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Amounts of elastic fibers predict prognosis of idiopathic pulmonary fibrosis． (2012)
  • Author(s): Enomoto N
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Phase II study Of Erlotinib as third-line monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations． (2012)
  • Author(s): Matsuura S
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] Real time imaging analysis of the enhanced fibrinolytic activity by newly synthesized inhibitor of plasminogen activator inhibitor-1 on vascular endothelial cell surface. (2012)
  • Author(s): Yasui H
  • Organizer: American Thoracic Society
  • Place of Presentation: San Francisco
• [Presentation] 間質性肺炎と膠原病 (2011)
  • Author(s): 千田金吾
  • Organizer: 日本内科学会講演会シンポジウム
  • Place of Presentation: パシフィコ横浜(震災のため変更,日時短縮)
  • Year and Date: 2011-11-13
• [Presentation] 膠原病からみた特発性間質性肺炎 (2010)
  • Author(s): 千田金吾
  • Organizer: 第50回日本呼吸器学会総会
  • Place of Presentation: 京都
• [Book] 医学記憶術 (2013)
  • Author(s): 千田金吾
  • Publisher: 南江堂
• [Book] 今日の治療指針 (2012)
  • Author(s): 千田金吾
  • Publisher: 医学書院
• [Book] 内科検査・手技マニュアル (2011)
  • Author(s): 千田金吾
  • Total Pages: 393
  • Publisher: 南江堂