Basic study for development of new therapy on ALI/ARDS by targeting flavonoid-induced HO-1

• Project/Area Number: 22590856
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagoya University
• Principal Investigator: KAWABE Tsutomu 名古屋大学, 医学系研究科(保健), 教授 (20378219)
• Co-Investigator(Kenkyū-buntansha): MATSUSHIMA Miyoko 名古屋大学, 医学系研究科(保健), 助教 (10509665)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: フラボノイド / heme oxygenase-1 / 急性肺損傷/急性呼吸促迫症候群(ALI/ARDS) / 急性肺損傷/急性呼吸促迫症候群 / 非閉塞性肺疾患 / 肺線維症

Research Abstract

Tissue destruction by activated neutrophils invading in the lungs is important in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Pulmonary fibrosis or restoration of the normal pulmonary architecture occurs after ALI/ARDS, and there is no specific therapy available yet in preventing and/or treating ALI/ARDS. In this study, we showed that quercetin, one of the flavonoids, suppressed lung damage via Nrf2-HO-1 pathway and the possibilitiesof using flavonoids to develop drug therapy for ALI/ARDS

Research Products

• [Journal Article] Anaqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans (2013)
  • Author(s): Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y
  • Journal Title: Respirology Volume: 18(2) Issue: 2 Pages: 340-7
  • DOI: 10.1111/j.1440-1843.2012.02286.x
  • Peer Reviewed
• [Journal Article] Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. (2013)
  • Author(s): Tamio Ohno
  • Journal Title: Immunogenetics Volume: 65 Issue: 1 Pages: 17-24
  • DOI: 10.1007/s00251-012-0656-7
  • Peer Reviewed
• [Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. (2012)
  • Author(s): Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 303(1) Issue: 1 Pages: L43-L53
  • DOI: 10.1152/ajplung.00061.2012
  • Peer Reviewed
• [Journal Article] Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery (2012)
  • Author(s): Matsuo M, Hashimoto N, Usami N, Imaizumi K, Wakai K, Kawabe T, Yokoi K, Hasegawa Y
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 14(5) Issue: 5 Pages: 560-4
  • DOI: 10.1093/icvts/ivr090
  • Peer Reviewed
• [Journal Article] Observation of fine lung structure by ultrahigh resolution optical coherence tomography using 800, 1060, and 1300 nm supercontinua (2012)
  • Author(s): S.Ishida, N.Nishizawa, M.Kitatsuji, H.Ohshima, Y.Hasegawa, M.Matsushima, T.Kawabe
  • Journal Title: Japanese Journal of Applied Physics Volume: 51 Issue: 4R Pages: 47001-47001
  • DOI: 10.1143/jjap.51.047001
  • Peer Reviewed
• [Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells (2012)
  • Author(s): Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: iochem. Biophys. Res. Commun. Volume: 417(1) Issue: 1 Pages: 169-74
  • DOI: 10.1016/j.bbrc.2011.11.078
  • Peer Reviewed
• [Journal Article] The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children (2012)
  • Author(s): Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto T, Borres MP
  • Journal Title: Clin Mol Allergy Volume: 10(1) Issue: 1 Pages: 1-1
  • DOI: 10.1186/1476-7961-10-1
  • Peer Reviewed
• [Journal Article] Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua (2012)
  • Author(s): Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T
  • Journal Title: Jpn.J.Appl.Phys. Volume: 51 Pages: 47001-47001
  • NAID: 210000140464
  • Peer Reviewed
• [Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells (2011)
  • Author(s): Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
  • Journal Title: Mol Carcinog Volume: E1 Issue: 5 Pages: 1-11
  • DOI: 10.1002/mc.20802
  • Peer Reviewed
• [Journal Article] Screening of IgG-Fc Binding Peptides from Milk Protein Using Slide Glass Type-Exclusive Peptide Array (2011)
  • Author(s): 片山 真、杉田智哉、加藤竜司、大河内美奈、 松島充代子、 川部 勤、高瀬智和、吉田安子、川瀬三雄、本多裕之
  • Journal Title: KAGAKU KOGAKU RONBUNSHU Volume: 37 Issue: 6 Pages: 546-550
  • DOI: 10.1252/kakoronbunshu.37.546
  • NAID: 10030160249
  • ISSN: 0386-216X, 1349-9203
  • Peer Reviewed
• [Journal Article] CD40/CD40 ligand interactions in immune responses and pulmonary immunity (2011)
  • Author(s): Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y
  • Journal Title: Nagoya J Med Sci Volume: 73 (3-4) Pages: 69-78
  • NAID: 120003277467
  • URL: http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7334/v73n34p69_78.pdf
  • Peer Reviewed
• [Journal Article] Attenuation of TGF-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1 (2011)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: Am J Respir Cell Mol Biol Volume: 44(5) Issue: 5 Pages: 614-620
  • DOI: 10.1165/rcmb.2010-0338oc
  • Peer Reviewed
• [Journal Article] Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants (2011)
  • Author(s): Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T
  • Journal Title: Early Hum. Dev Volume: 87(3) Pages: 151-157
  • NAID: 120003059531
  • Peer Reviewed
• [Journal Article] Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants. (2011)
  • Author(s): Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T.
  • Journal Title: Early Hum Dev. Volume: 87 Pages: 151-157
  • NAID: 120003059531
  • Peer Reviewed
• [Journal Article] Attenuation of TGF-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. (2011)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 44 Pages: 614-620
  • Peer Reviewed
• [Journal Article] Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways (2010)
  • Author(s): Shikida M, Yokota T, Kawabe T, Funaki T, Matsushima M, Iwai S, Matsunaga N, SatoK
  • Journal Title: J. Micromech. Microen Volume: 20 (12) Pages: 1-11
  • Peer Reviewed
• [Journal Article] Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. (2010)
  • Author(s): Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K
  • Journal Title: Peptides Volume: 31(11) Pages: 2109-2113
  • Peer Reviewed
• [Journal Article] Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. (2010)
  • Author(s): Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 43(2) Issue: 2 Pages: 161-72
  • DOI: 10.1165/rcmb.2009-0031oc
  • Peer Reviewed
• [Journal Article] Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways. (2010)
  • Author(s): Shikida M, Yokota T, Kawabe T, Funaki T, Matsushima M, Iwai S, Matsunaga N, Sato K.
  • Journal Title: J.Micromech. Microeng. Volume: 20
  • Peer Reviewed
• [Journal Article] Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. (2010)
  • Author(s): Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K.
  • Journal Title: Peptides. Volume: 31 Pages: 2109-21013
  • Peer Reviewed
• [Journal Article] Endothelia1-mesenchymal transition in bleomycin-induced pulmonary fibrosis. (2010)
  • Author(s): Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 43 Pages: 161-172
  • Peer Reviewed
• [Presentation] Three-dimensional ultrahigh-resolution optical coherence tomography imaging of lung tissues. (2013)
  • Author(s): Shutaro Ishida
  • Organizer: BIOS
  • Place of Presentation: The Moscone Center (USA)
• [Presentation] Analysis of IgE-binding epitope variation in the allergen after repeated immunization (2012)
  • Author(s): Yamaguchi T, Matsushima M, Nose H, Kawabe T
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2012-12-06
• [Presentation] Attenuation of Transforming Growth Factor-β-Stimulated Collagen Production in Fibroblasts by Chrysin (2012)
  • Author(s): Nose H, Matsushima M, Yamaguchi T, Kawabe T
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] The Effect of Quercetin on the Activation of Alveolar Macrophages (2012)
  • Author(s): Matsushima M, Nose H, Yamaguchi T, Kawabe T.
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] 回な抗原の曝露による IgE 認識エピトープの解析 (2012)
  • Author(s): 山口剛広、松島充代子、川部 勤
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-12-01
• [Presentation] 線維化に及ぼすクリシンの効果の検討 (2012)
  • Author(s): 野瀬遥加、松島充代子、太田川茅沙、川部 勤
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-12-01
• [Presentation] 微細気流計を用いた喘息モデルマウスの気流変化の観察 (2012)
  • Author(s): 島充代子、式田光宏、山本ゆき、吉川和宏、鹿野嵩瑛、川部 勤
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-11-29
• [Presentation] 超高分解能 OCT による肺組織の 3 次元高解像度断層イメージング (2012)
  • Author(s): 西澤典彦、石田周太郎、北辻真史、大島啓嘉、松島充代子、川部 勤
  • Organizer: 日本光学会年次大会Optics & Photonics Japan 2012
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2012-10-24
• [Presentation] 膠原線維産生に及ぼすクリシンの効果についての検討 (2012)
  • Author(s): 野瀬遥加、松島充代子、太田川茅沙、川部 勤
  • Organizer: 第7回日本臨床検査教育協議会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-08-24
• [Presentation] IgE結合部位からみたアレルゲンの抗原性の変化 (2012)
  • Author(s): 山口剛広、松島充代子、川部 勤
  • Organizer: 第7回日本臨床検査教育協議会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-08-23
• [Presentation] 超高分解能 OCT を用いた正常ならびに疾患肺の組織学的検討 (2012)
  • Author(s): 高嶋浩司、松島充代子、西澤典彦、北辻真史、大島博嘉、長谷川好規、 川部 勤
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2012-04-21
• [Presentation] TGF-β-stimulated collagen production in fibroblasts is attenuated by quercetin-induced heme oxygenase-1 (2012)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Hasegawa Y, Kawabe T
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2012-04-20
• [Presentation] 肥満細胞活性化におけるクリシンの効果 (2012)
  • Author(s): 松島充代子、寺西彩香、小笠原名奈子、山本祐規子、高木 健三、川部 勤
  • Organizer: 第132回日本薬学会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-29
• [Presentation] MEASUREMENT OF BREATHING CHARACTERISTIC IN MOUSE DURING INHALING DRUG (2012)
  • Author(s): Shikano T., Shikida M., Matsushima M., Kawabe T., and Sato K
  • Organizer: 25th International Conference on Micro Electro Mechanical Systems
  • Place of Presentation: Marriott Paris Rive Gauche Hotel (Paris, France)
  • Year and Date: 2012-02-02
• [Presentation] MEASUREMENT OF BREATHING CHARACTERISTIC IN MOUSE DURING INHALING DRUG (2012)
  • Author(s): Shikano T., Shikida M., Matsushima M., Kawabe T., Sato K
  • Organizer: 25th International Conference on Micro Electro Mechanical Systems
  • Place of Presentation: The Moscone Center (San Francisco, California, USA)
  • Year and Date: 2012-02-02
• [Presentation] Ultrahigh resolution optical coherence tomography imaging of diseased rat lung using Gaussian shaped super continuum sources (2012)
  • Author(s): Nishizawa N., Ishida S., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., and Kawabe T
  • Organizer: BIOS
  • Place of Presentation: The Moscone Center (San Francisco, California, USA)
  • Year and Date: 2012-01-20
• [Presentation] CATHETER FLOW SENSOR SYSTEM AND BREATHING MEASUREMENTS IN RABBIT. (2012)
  • Author(s): Takuya Matsuyama
  • Organizer: IEEE SENSORS 2012
  • Place of Presentation: Taipei International Convention Center (Taiwan)
• [Presentation] INTEGRATION OF TEMPERATURE DETECTION ONTO CATHETER FLOW SENSOR FOR BRONCHOSCOPE (2012)
  • Author(s): Yudai Yamazaki
  • Organizer: IEEE SENSORS 2012
  • Place of Presentation: Taipei International Convention Center (Taiwan)
• [Presentation] Detection of airflow change by thermal flow microsensor in disease model rabbits. (2012)
  • Author(s): Miyoko Matsushima
  • Organizer: 22th Congress of Interasthma Japan North Asia
  • Place of Presentation: 九州大学医学部百年講堂
• [Presentation] Analysis of IgE-binding epitope variation in the allergen after repeated immunization. (2012)
  • Author(s): 山口剛広
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Attenuation of Transforming Growth Factor-β-Stimulated Collagen Production in Fibroblasts by Chrysin (2012)
  • Author(s): 野瀬遥加
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] The Effect of Quercetin on the Activation of Alveolar Macrophages (2012)
  • Author(s): 松島充代子
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] 頻回な抗原の曝露によるIgE認識エピトープの解析 (2012)
  • Author(s): 山口剛広
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 線維化に及ぼすクリシンの効果の検討 (2012)
  • Author(s): 野瀬遥加
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 微細気流計を用いた喘息モデルマウスの気流変化の観察 (2012)
  • Author(s): 松島充代子
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 超高分解能OCTによる肺組織の3次元高解像度断層イメージング (2012)
  • Author(s): 西澤典彦
  • Organizer: 日本光学会年次大会Optics & Photonics Japan 2012
  • Place of Presentation: タワーホール船堀
• [Presentation] 膠原線維産生に及ぼすクリシンの効果についての検討 (2012)
  • Author(s): 野瀬遥加
  • Organizer: 第7回日本臨床検査教育協議会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] IgE結合部位からみたアレルゲンの抗原性の変化 (2012)
  • Author(s): 山口剛広
  • Organizer: 第7回日本臨床検査教育協議会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 超高分解能OCTを用いた正常ならびに疾患肺の組織学的検討 (2012)
  • Author(s): 高嶋浩司
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] TGF-β -stimulated collagen production in fibroblasts is attenuated by quercetin-induced heme oxygenase–1 (2012)
  • Author(s): 中村俊信
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] 超高分解能 OCT による肺組織の高解像度観察Ultrahigh resolution OCT imaging of lung tissues (2011)
  • Author(s): 西澤典彦、石田周太郎、北辻真史、大島啓嘉、松島充代子、川部 勤
  • Organizer: 日本光学会年次学術講演会Optics & Photonics Japan 2011
  • Place of Presentation: 大阪大学・吹田キャンパス(大阪府)
  • Year and Date: 2011-11-30
• [Presentation] 超高分解能OCTによる肺組織の高解像度観察Ultrahigh resolution OCT imaging of lung tissues (2011)
  • Author(s): 西澤典彦、石田周太郎、北辻真史、大島啓嘉、松島充代子、川部勤
  • Organizer: 日本光学会年次学術講演会Optics & Photonics Japan 2011
  • Place of Presentation: 大阪大学・吹田キャンパス(大阪府)
  • Year and Date: 2011-11-30
• [Presentation] Analysis on the inhibitory effect of chrysin in mast cell degranulation (2011)
  • Author(s): 寺西彩香、松島充代子 、 川部 勤
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)20. 松島
  • Year and Date: 2011-11-29
• [Presentation] Analysis on the inhibitory effect of chrysin in mast cell degranulation (2011)
  • Author(s): 寺西彩香、松島充代子、川部勤
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Presentation] ケルセチンの抗線維化作用と HO-1 の関与 (2011)
  • Author(s): 松島充代子、中村俊信、今泉和良、長谷川好規、川部 勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール(東京都)
  • Year and Date: 2011-11-12
• [Presentation] ケルセチンの抗線維化作用とHO-1の関与 (2011)
  • Author(s): 松島充代子、中村俊信、今泉和良、長谷川好規、川部勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京都)
  • Year and Date: 2011-11-12
• [Presentation] クリシンの脱顆粒抑制機序の検討 (2011)
  • Author(s): 寺西彩香、松島充代子、山本祐規子、高木健三、川部 勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール(東京都)
  • Year and Date: 2011-11-11
• [Presentation] クリシンの脱顆粒抑制機序の検討 (2011)
  • Author(s): 寺西彩香、松島充代子、山本祐規子、高木健三、川部勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京都)
  • Year and Date: 2011-11-11
• [Presentation] 抗原に対する抗体の高親和性獲得における CD40 の役割 (2011)
  • Author(s): 山本祐規子、松島充代子、寺西彩香、高木健三、川部 勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール(東京都)
  • Year and Date: 2011-11-10
• [Presentation] 抗原に対する抗体の高親和性獲得におけるCD40の役割 (2011)
  • Author(s): 山本祐規子、松島充代子、寺西彩香、高木健三、川部勤
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京都)
  • Year and Date: 2011-11-10
• [Presentation] Heme oxygenase-1 induced by quercetin attenuates TGF-β-stimulated collagen production in fibroblasts (2011)
  • Author(s): Kawabe T, Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y
  • Organizer: ERS Amsterdam 2011 Congress
  • Place of Presentation: RAI Amsterdam (Amsterdam, Netherlands)
  • Year and Date: 2011-09-26
• [Presentation] Development of thermal flow microsensor for transbronchial measurement of local lung function (2011)
  • Author(s): Matsushima M, Shikida M, Yamamoto Y, Yamamoto Y, Iwai S, Shikano T, Kawabe T
  • Organizer: 21th Congress of Interasthma Japan North Asia
  • Place of Presentation: 岐阜都ホテル(岐阜県)
  • Year and Date: 2011-07-01
• [Presentation] Development of thermal flow microsensor for transbronchial measurement of local lung function (2011)
  • Author(s): Matsushima M, Shikida M, Yamamoto Y, Yamatnoto Y, Iwai S, Shikano T, Kawabe T
  • Organizer: 21^<th> Congress of Interasthma Japan North Asia
  • Place of Presentation: 岐阜都ホテル(岐阜県)
  • Year and Date: 2011-07-01
• [Presentation] 脱顆粒抑制能をもつクリシンの作用機序の検討 (2011)
  • Author(s): 寺西彩香、松島充代子、森 朱美、山本祐規子、高木健三、川部 勤
  • Organizer: 第42回日本職業・環境アレルギー学会総会・学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-06-03
• [Presentation] 組織観察用超分解能 OCT の開発 (2011)
  • Author(s): 松島充代子、長谷川好規、川部 勤
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-05-15
• [Presentation] 肺組織観察用超分解能OCTの開発 (2011)
  • Author(s): 松島充代子、長谷川好規、川部勤
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-05-15
• [Presentation] Ultrahigh resolution optical coherence tomography imaging of lung structure using Gaussian shaped super continuum sources. (2011)
  • Author(s): Nishizawa N., Ishida S., Ohta T.Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., Kawabe T.
  • Organizer: BIOS
  • Place of Presentation: USA
  • Year and Date: 2011-02-22
• [Presentation] Ultrahigh resolution optical coherence tomography imaging of lung structure using Gaussian shaped super continuum sources (2011)
  • Author(s): Nishizawa N., Ishida S., Ohta T. Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y.,Matsushima M., and Kawabe T
  • Organizer: BIOS
  • Place of Presentation: USA
• [Presentation] Ex-vivo ultra-high-resolution optical coherence tomography imaging of fine lung structure by use of a high-power Gaussian-like supercontinuum at 0.8-um wavelength (2011)
  • Author(s): Nishizawa N., Ishida S., Ohta T. Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., and Kawabe T
  • Organizer: BIOS
  • Place of Presentation: USA
• [Presentation] クリシンの抗アレルギー作用と HO-1 の関与 (2010)
  • Author(s): 寺西彩香、松島充代子、森 朱美、山本祐規子、高木健三、川部 勤
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム (東京都)
  • Year and Date: 2010-11-25
• [Presentation] 肥満細胞の TNF-α 産生に対するフラボノイドの効果と HO-1 の関与 (2010)
  • Author(s): 森 朱美、松島充代子、寺西彩香、山本祐規子、高木健三、川部 勤
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム (東京都)
  • Year and Date: 2010-11-25
• [Presentation] 肥満細胞のTNF-α産生に対するフラボノイドの効果とHO-1の関与 (2010)
  • Author(s): 寺西彩香、松島充代子、森朱美、山本祐規子、高木健三、川部勤
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] クリシンの抗アレルギー作用とHO-1の関与 (2010)
  • Author(s): 森朱美、松島充代子、寺西彩香、山本祐規子、高木健三、川部勤
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] ガウス型スーパーコンティニューム光を用いた肺組織の超高分解能OCT イメージング Ultrahigh resolution optical coherence tomography imaging of lung tissue using Gaussian shaped super continuum sources (2010)
  • Author(s): 西澤典彦、石田周太郎、太田健史、伊東一良、北辻真史、大島啓嘉、 松島充代子、川部勤
  • Organizer: 日本光学会年次学術講演会 Optics & Photonics Japan 2010
  • Place of Presentation: 中央大学 駿河台記念館(東京都)
  • Year and Date: 2010-11-09
• [Presentation] ペプチドアレイへのIgE/IgG4 の結合パターンによるミルクアレルギー診断 (2010)
  • Author(s): 片山真、加藤竜司、大河内美奈、本多裕之、川部勤、松島充代子、川瀬三雄、吉田安子、高瀬智和
  • Organizer: 化学工学会第42回秋季大会
  • Place of Presentation: 同志社大学 今出川キャンパス(京都府)
  • Year and Date: 2010-09-06
• [Presentation] Structure-activity relationship of flavonoids for anti-allergic effects and the induction of heme oxygenase-1 in RBL-2H3 cells (2010)
  • Author(s): Matsushima M, Hirayama T, Mori A, Kawabe T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-08-23
• [Presentation] Structure-activity relationship of flavonoids for anti-allergic effects and the induction of heme oxygenase-1 in RBL-2H3 CellS. (2010)
  • Author(s): Matsushima M, Hirayama T, Mori A, Kawabe M.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] フラボノイドの抗アレルギー作用および HO-1 の発現誘導を決定する構造の探索 (2010)
  • Author(s): 松島充代子、高木健三、森 朱美、寺西彩香、山本祐規子、川部 勤
  • Organizer: 第41回日本職業・環境アレルギー学会総会・学術大会
  • Place of Presentation: 高崎ビューホテル(群馬県)
  • Year and Date: 2010-07-16
• [Presentation] フラボノイドの抗アレルギー作用およびHO-1の発現誘導を決定する構造の探索 (2010)
  • Author(s): 松島充代子、高木健三、森朱美、寺西彩香、山本祐規子、川部勤
  • Organizer: 第41回日本職業・環境アレルギー学会総会・学術大会
  • Place of Presentation: 群馬
  • Year and Date: 2010-07-16
• [Presentation] Implantable flow sensor into airway for laboratory animal (2010)
  • Author(s): Matsunaga N., Yokota T., Shikida M., Kawabe T., Matsushima M., Iwai S., Sato K
  • Organizer: APCOT
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-07-08
• [Presentation] Implantable flow sensor into airway for laboratory animal. (2010)
  • Author(s): Matsunaga M., Yokota T., Shikida M, Kawabe T, Matsushima M., Iwai s., Sato K.
  • Organizer: APCOT
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-07-08
• [Presentation] フラボノイドの HO-1 を介した抗アレルギー作用と C 環 2 重結合の意義 (2010)
  • Author(s): 森 朱美、松島充代子、寺西彩香、山本祐規子、高木健三、川部 勤
  • Organizer: 第6回日本食品免疫学会
  • Place of Presentation: 東京大学安田講堂(東京都)
  • Year and Date: 2010-06-01
• [Presentation] フラボノイドのHO-1を介した抗アレルギー作用とC環2重結合の意義 (2010)
  • Author(s): 森朱美、松島充代子、寺西彩香、山本祐規子、高木健三、川部勤
  • Organizer: 第6回日本食品免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-01
• [Presentation] フラボノイドによるHO-1 を介した抗アレルギー作用とその構造 (2010)
  • Author(s): 森 朱美、川部 勤、松島充代子、平山達也、高木健三
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-05-08
• [Presentation] フラボノイドによるHO-1を介した抗アレルギー作用とその構造 (2010)
  • Author(s): 森朱美、川部勤、松島充代子、平山達也、高木健三
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-08
• [Book] 免疫学コア講義 改訂 3 版 (2012)
  • Author(s): 熊之郷淳、坂口薫雄、竹田 潔、吉田裕樹
  • Publisher: 南山堂
• [Book] 免疫学コア講義 改訂3版 (2012)
  • Author(s): 熊之郷淳
  • Publisher: 南山堂
• [Remarks] 研究室 HP
  • URL: http://square.umin.ac.jp/kawabe/index.html
• [Remarks] 研究室ホームページ
  • URL: http://square.umin.ac.jp/kawabe/index.html
• [Patent(Industrial Property Rights)] 生体埋め込み型流量センサ (2010)
  • Inventor(s): 式田光宏、川部 勤、松島充代子、横田拓央、岩井 聡、松永直之
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Filing Date: 2010-08-10
  • Overseas