Exploration of new therapy and diagnosis in lymph metastasis of lung cancer based on theprofile of lymphangiogenic-related genes expression
| Project/Area Number |
22590857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Fujita Health University (2011-2012)
Nagoya University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Mitsuo 名古屋大学, 医学系研究科, 講師 (70467281)
橋本 直純 名古屋大学, 医学部附属病院, 助教 (30378020)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 呼吸器病学 / 肺がん / リンパ節 / EMT / HIF1α / VEGF / 内科 / 呼吸器内科 / 肺癌 / リンパ節転移 |
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| Research Abstract |
Based on our recognition for the importance of tumor microenvironment(TM), TM induces acquisition of malignant phenotype such as epithelial-mesenchymal transition (EMT), resulting in metastasis into lymph nodes. In this study, persistent tissue hypoxia might be involved in tumor tissue in an in vivo orthotopic intrapulmonary implantation model. Persistent hypoxia also induced the stabilized HIF1α expression in lung cancer cells. Transduction of HIF1α into lung cancers with the Doxycycline inducible gene expression system caused de novo VEGF-A expression. Taken together with the evidence of increasing VEGF receptor expression lymphatic endothelial cells in sentinel lymph nodes, hypoxia as TM in lung cancers might be a therapeutic target for the metastasis into lymph nodes and lymphangiogenesis.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Endobronchial ultrasound transbronchial needle aspiration in older people2013
Author(s)
Okachi S, Imai N, Imaizumi K, Hase T,Shindo Y, Sakamoto K, Aso H, Wakahara K,Hashimoto I, Ito S, Hashimoto N, Sato M,Kondo M, Hasegawa Y.
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Journal Title
Geriatr Gerontol Int
Volume: 13
Issue: 4
Pages: 986-992
DOI
Related Report
Peer Reviewed
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[Journal Article] An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans.2013
Author(s)
Hashimoto I, Imaizumi K, Hashimoto N,Furukawa H, Noda Y, Kawabe T, Honda T,Ogawa T, Matsuo M, Imai N, Ito S, Sato M,Kondo M, Shimokata K, Hasegawa Y.
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Journal Title
Respirology
Volume: 18(2)
Pages: 340-347
Related Report
Peer Reviewed
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[Journal Article] Anaqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans2013
Author(s)
Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y
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Journal Title
Respirology
Volume: 18(2)
Issue: 2
Pages: 340-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Non-Genomic Effects of Fluticasone Propionate and Budesonide on Human Airway Anion Secretion2012
Author(s)
Mizutani T, Morise M, Ito Y, Hibino Y,Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y
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Journal Title
Am J Respir Cell Mol Biol
Volume: 47(5)
Pages: 645-51
Related Report
Peer Reviewed
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[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.2012
Author(s)
Sakamoto K, Hashimoto N, Kondoh Y,Imaizumi K, Aoyama D, Kohnoh T,Kusunose M, Kimura M, Kawabe T,Taniguchi H, Hasegawa Y
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 303(1)
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Peer Reviewed
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[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.2012
Author(s)
Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y.
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 303(1)
Issue: 1
Pages: L43-L53
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells.2011
Author(s)
Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M,Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y
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Journal Title
Mol Carcinog.
Volume: 51(5)
Pages: 400-410
Related Report
Peer Reviewed
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[Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinase- and cAMP-dependent mechanisms2011
Author(s)
Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45(4)
Pages: 684-91
Related Report
Peer Reviewed
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[Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells2011
Author(s)
Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
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Journal Title
Mol Carcinog
Volume: E1
Issue: 5
Pages: 1-11
DOI
Related Report
Peer Reviewed
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