| Project/Area Number |
22590860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUBOI Tomomasa 京都大学, 医学(系)研究科(研究院), 非常勤講師 (00536724)
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| Co-Investigator(Kenkyū-buntansha) |
CHIN Kazuo 京都大学, 医学(系)研究科(研究院), 教授 (90197640)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
HOSHINO Yuma 京都大学, 医学(系)研究科(研究院), 助教 (00378746)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 閉塞型睡眠時無呼吸 / 遺伝子多型 / 持続的低酸素 / 間欠的低酸素 / 睡眠時無呼吸 / heme oxygenase-1 / 酸化ストレス / 呼気一酸化炭素 |
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| Research Abstract |
It is said that patients with severe obstructive sleep apnea (OSA) show higher mortality than controls because of a significant increase in cardiovascular diseases in the former. However, not all but some of the patients with severe OSA have poor prognosis. We hypothesized that the differences in mortality rate among the patients with severe OSA were due to the genetic polymorphism. We have got the blood from 306 patients with OSA and done the gene extraction from them. In addition, we found thatUrinary Lipocalin-type prostaglandin D synthase (L-PGDS) might be a moderately useful marker to identify patients with severe OSA. We also made a new instrument which could produce both intermittent and sustained hypoxic conditions for the target cells. From that instrument, we could find that the intermittent hypoxia induced TNF-α and sustained hypoxia induced hypoxia inducible factor-1.
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