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Gene polymorphisms in patients with sleep apnea and cell responses to hypoxia

Research Project

Project/Area Number 22590860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

TSUBOI Tomomasa  京都大学, 医学(系)研究科(研究院), 非常勤講師 (00536724)

Co-Investigator(Kenkyū-buntansha) CHIN Kazuo  京都大学, 医学(系)研究科(研究院), 教授 (90197640)
HORIUCHI Hisanori  東北大学, 加齢研究所, 教授 (90291426)
HOSHINO Yuma  京都大学, 医学(系)研究科(研究院), 助教 (00378746)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords閉塞型睡眠時無呼吸 / 遺伝子多型 / 持続的低酸素 / 間欠的低酸素 / 睡眠時無呼吸 / heme oxygenase-1 / 酸化ストレス / 呼気一酸化炭素
Research Abstract

It is said that patients with severe obstructive sleep apnea (OSA) show higher mortality than controls because of a significant increase in cardiovascular diseases in the former. However, not all but some of the patients with severe OSA have poor prognosis. We hypothesized that the differences in mortality rate among the patients with severe OSA were due to the genetic polymorphism. We have got the blood from 306 patients with OSA and done the gene extraction from them. In addition, we found thatUrinary Lipocalin-type prostaglandin D synthase (L-PGDS) might be a moderately useful marker to identify patients with severe OSA. We also made a new instrument which could produce both intermittent and sustained hypoxic conditions for the target cells. From that instrument, we could find that the intermittent hypoxia induced TNF-α and sustained hypoxia induced hypoxia inducible factor-1.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (10 results) (of which Invited: 2 results) Book (3 results)

  • [Journal Article] Flexible positive airway pressure improves treatment adherence compared with auto-adjusting PAP2013

    • Author(s)
      Chihara Y, Tsuboi T, Hitomi T, Azuma M, Murase K, Toyama Y, Harada Y, Aihara K, Tanizawa K, Handa T, Yoshimura C, Oga T, Yamamoto K, Mishima M, Chin K
    • Journal Title

      Sleep

      Volume: 36:229-36 Issue: 2 Pages: 229-236

    • DOI

      10.5665/sleep.2378

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of anatomical and functional determinants of obstructive sleep apnea2012

    • Author(s)
      Aihara K, Oga T, Harada Y, Chihara Y, Handa T, Tanizawa K, Watanabe K, Hitomi T, Tsuboi T, Mishima M, Chin K
    • Journal Title

      Sleep Breath

      Volume: 16: 473-81 Issue: 2 Pages: 473-481

    • DOI

      10.1007/s11325-011-0528-7

    • NAID

      120004247248

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸器疾患と動脈硬化症2012

    • Author(s)
      谷澤公伸、坪井知正、陳和夫
    • Journal Title

      Angiology Frontier

      Volume: 11:189-97

    • URL

      http://mol.medicalonline.jp/library/archive/search?jo=ai1angid&ye=2012&vo=11&nu=3&st=189&UserID=130.54.110.73

    • Related Report
      2012 Final Research Report
  • [Journal Article] 呼吸器疾患と動脈硬化症2012

    • Author(s)
      谷澤公伸, 坪井知正, 陳和夫
    • Journal Title

      Angiology Frontier

      Volume: 11 Pages: 189-197

    • Related Report
      2012 Annual Research Report
  • [Journal Article] PaCO2 Six months after the Initiation of Long-term Noninvasive Ventilation in Patients with COPD2011

    • Author(s)
      Tsuboi T, Oga T, Machida K, Sumi K, Oguri S, Sato A, Kurasawa T, Ohi M, Mishima M, Chin K
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 6 Pages: 563-570

    • DOI

      10.2169/internalmedicine.50.4310

    • NAID

      130000649886

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immediate noninvasive ventilation may improve mortality in patients with hepatopulmonary syndrome after liver transplantation2011

    • Author(s)
      Chihara Y, Egawa H, Tsuboi T, Oga T, Handa T, Yamamoto K, Mishima M Tanaka K, Uemoto S, Chin K
    • Journal Title

      Liver Transplantation

      Volume: 17:144-8 Issue: 2 Pages: 144-148

    • DOI

      10.1002/lt.22207

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 間欠的低酸素2011

    • Author(s)
      谷澤公伸、陳和夫
    • Journal Title

      medicina

      Volume: 48:956-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immediate noninvasive ventilation may improve mortality in patients with hepatopulmonary syndrome after liver transplantation.2011

    • Author(s)
      Chihara Y, Egawa H, Tsuboi T, Oga T, Handa T, Yamamoto K, Mishima M Tanaka K, Uemoto S, Chink K.
    • Journal Title

      Liver Transplantation

      Volume: 17 Pages: 144-148

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the PaCO2from 3 to 6 months after initiation of long-term non-invasive ventilation2010

    • Author(s)
      Tsuboi T, Ohi M, Oga T, Machida K, Chihara Y, Harada Y, Takahashi K, Sumi K, Handa T, Niimi A, Mishima M, Chin K
    • Journal Title

      Respir Med

      Volume: 104:1850-7 Issue: 12 Pages: 1850-1857

    • DOI

      10.1016/j.rmed.2010.04.027

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age2010

    • Author(s)
      Aihara K, Chin K, Oga T, Takahashi K, Hitomi T, Takegami M, Handa T, Niimi A, Tsuboi T, Mishima M
    • Journal Title

      Hypertension Research

      Volume: 33:1025-31 Issue: 10 Pages: 1025-1031

    • DOI

      10.1038/hr.2010.133

    • NAID

      10027475257

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of non-invasive ventilation for life-threatening asthma attacks: Changes in the need for intubation2010

    • Author(s)
      Murase K, Tomii K, Chin K, Tsuboi T,Sakurai A, Tachikawa R, Harada Y, Takeshima Y, Hayashi M, Ishihara K
    • Journal Title

      Respirology

      Volume: 15:714-20 Issue: 4 Pages: 714-720

    • DOI

      10.1111/j.1440-1843.2010.01766.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Ventilation Improves the Outcome of Pulmonary Complications after Liver Resection2010

    • Author(s)
      Narita M, Tanizawa K, Chin K, Ikai I, Handa T, Oga T, Niimi A, Tsuboi T, Mishima M, Uemoto S, Hatano E
    • Journal Title

      Internal Medicine

      Volume: 49 Issue: 15 Pages: 1501-1507

    • DOI

      10.2169/internalmedicine.49.3375

    • NAID

      130000299569

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the PaCO(2) from 3 to 6 months after initiation of long-term non-invasive ventilation.2010

    • Author(s)
      Tomomasa Tsuboi, Motoharu Ohi, Kazuko Machida, Toru Oga, Yuichi Chihara, Yuka Harada, Kenichi Takahashi, Kensuke Sumi, Tomohiro Handa, Akio Niimi, Michiaki Mishima, Kazuo Chin.
    • Journal Title

      Respir Med.

      Volume: 104(12) Pages: 1850-1857

    • NAID

      120002723137

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PaCO2 six months after the initiation of long-term noninvasive ventilation in patients with COPD.2010

    • Author(s)
      Tomomasa Tsuboi, Toru Oga, Kazuko Machida, Kensuke Sumi, Susumu Oguri, Atsuo Sato, Takuya Kurasawa, Motoharu Chi, Michiaki Mishima, Kazuo Chin.
    • Journal Title

      Intern Med.

      Volume: 50 Pages: 563-570

    • NAID

      130000649886

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age2010

    • Author(s)
      Aihara K, Chin K, Oga T, Takahashi K, Hitomi T, Takegami M, Handa T, Niimi A, Tsuboi T, Mishima M.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 1025-31

    • NAID

      10027475257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of non-invasive ventilation for life-threatening asthma attacks : Changes in the need for intubation.2010

    • Author(s)
      Murase K, Tomii K, Chin K, Tsuboi T, Sakurai A, Tachikawa R, Harada Y, Takeshima Y, Hayashi M, Ishihara K.
    • Journal Title

      Respirology

      Volume: 15 Pages: 714-720

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive ventilation improves the outcomes of pulmonary complications after liver resection.2010

    • Author(s)
      Narita M, Tanizawa K, Chin K, Handa T, Oga T, Niimi A, Tsuboi T, Ikai I, Mishima M, Uemoto S, Hatano E.
    • Journal Title

      Internal Medicine

      Volume: 49 Pages: 1501-1507

    • NAID

      130000299569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A urine biomarker for severe OSA: Lipocaline-Type prostaglandin D synthase

    • Author(s)
      Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C, Hitomi T, Oga T, Mishima M, Urade Y
    • Journal Title

      European Respiratory Journal

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Associations between lifestyle-related diseases2012

    • Author(s)
      Chin K
    • Organizer
      sleep apnea and sleep duration. The 8thInternational Symposium on Respiratory Diseases & ATS in China Forum
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2012-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 肥満症と睡眠時無呼吸2012

    • Author(s)
      陳和夫
    • Organizer
      第33回日本肥満学会 教育講演
    • Place of Presentation
      京都市
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 肥満症と睡眠時無呼吸2012

    • Author(s)
      陳和夫
    • Organizer
      第33回日本肥満学会 教育講演
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Associations between lifestyle-related diseases, sleep apnea and sleep duration.2012

    • Author(s)
      Chin K
    • Organizer
      The 8th International Symposium on Respiratory Diseases & ATS in China Forum 2012
    • Place of Presentation
      Shanghai, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Effects of intermittent hypoxia on several parameters for cardiovasucular reisk factors2011

    • Author(s)
      Tanizawa K, Chin K
    • Organizer
      Industrial Symposium 4Metabolic risk of sleep apnea. Worldsleep 2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of intermittent hypoxia on several parameters for cardiovascular risk factors. Industrial Symposium 4 : Metabolic risk of sleep apnea2011

    • Author(s)
      Tanizawa K, Chin K
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efects of CPAP therapy on the several factors for morbidity in patients with OSA. Symposiumu 32011

    • Author(s)
      Chin K
    • Organizer
      The 8thAnnual Meeting of Korea Sleep Research Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-07-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of CPAP therapy on the several factors for morbidity in patients with OSA.Symposium 32011

    • Author(s)
      Chin K
    • Organizer
      The 8th Annual Meeting of Korea Sleep Research Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全身性疾患としての睡眠時無呼吸症候群2010

    • Author(s)
      谷澤公伸、陳和夫、星野勇馬、小賀徹
    • Organizer
      第50回日本呼吸器学会学術集会シンポジウム 12 間欠的低酸素と SAS
    • Place of Presentation
      京都市
    • Year and Date
      2010-04-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 全身性疾患としての睡眠時無呼吸症候群2010

    • Author(s)
      谷澤公伸、陳和夫、星野勇馬、小賀徹
    • Organizer
      第50回日本呼吸器学会学術講演会間欠的低酸素とSASシンポジウム12
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Book] Wageningen Academic, The Netherlands, Metabolism, metabolic syndrome, obesity and sleep2013

    • Author(s)
      Chin K, Harada Y
    • Total Pages
      500
    • Publisher
      Handbook of nutrition, diet and sleep
    • Related Report
      2012 Final Research Report
  • [Book] 睡眠時無呼吸. 看護学テキスト NICE 疾病と治療 I. 全身性/呼吸器系/循環器系/感染症/中毒/救急2010

    • Author(s)
      坪井知正、陳和夫
    • Total Pages
      366
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 看護学テキストNICE「疾病と治療1」2010

    • Author(s)
      松田暉、荻原俊男、難波光義、鈴木久美、林直子/総編集
    • Total Pages
      346
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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