Gene polymorphisms in patients with sleep apnea and cell responses to hypoxia
Project/Area Number |
22590860
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
TSUBOI Tomomasa 京都大学, 医学(系)研究科(研究院), 非常勤講師 (00536724)
|
Co-Investigator(Kenkyū-buntansha) |
CHIN Kazuo 京都大学, 医学(系)研究科(研究院), 教授 (90197640)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
HOSHINO Yuma 京都大学, 医学(系)研究科(研究院), 助教 (00378746)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 閉塞型睡眠時無呼吸 / 遺伝子多型 / 持続的低酸素 / 間欠的低酸素 / 睡眠時無呼吸 / heme oxygenase-1 / 酸化ストレス / 呼気一酸化炭素 |
Research Abstract |
It is said that patients with severe obstructive sleep apnea (OSA) show higher mortality than controls because of a significant increase in cardiovascular diseases in the former. However, not all but some of the patients with severe OSA have poor prognosis. We hypothesized that the differences in mortality rate among the patients with severe OSA were due to the genetic polymorphism. We have got the blood from 306 patients with OSA and done the gene extraction from them. In addition, we found thatUrinary Lipocalin-type prostaglandin D synthase (L-PGDS) might be a moderately useful marker to identify patients with severe OSA. We also made a new instrument which could produce both intermittent and sustained hypoxic conditions for the target cells. From that instrument, we could find that the intermittent hypoxia induced TNF-α and sustained hypoxia induced hypoxia inducible factor-1.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Flexible positive airway pressure improves treatment adherence compared with auto-adjusting PAP2013
Author(s)
Chihara Y, Tsuboi T, Hitomi T, Azuma M, Murase K, Toyama Y, Harada Y, Aihara K, Tanizawa K, Handa T, Yoshimura C, Oga T, Yamamoto K, Mishima M, Chin K
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Journal Title
Sleep
Volume: 36:229-36
Issue: 2
Pages: 229-236
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of anatomical and functional determinants of obstructive sleep apnea2012
Author(s)
Aihara K, Oga T, Harada Y, Chihara Y, Handa T, Tanizawa K, Watanabe K, Hitomi T, Tsuboi T, Mishima M, Chin K
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Journal Title
Sleep Breath
Volume: 16: 473-81
Issue: 2
Pages: 473-481
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] PaCO2 Six months after the Initiation of Long-term Noninvasive Ventilation in Patients with COPD2011
Author(s)
Tsuboi T, Oga T, Machida K, Sumi K, Oguri S, Sato A, Kurasawa T, Ohi M, Mishima M, Chin K
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Journal Title
Internal Medicine
Volume: 50
Issue: 6
Pages: 563-570
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Importance of the PaCO2from 3 to 6 months after initiation of long-term non-invasive ventilation2010
Author(s)
Tsuboi T, Ohi M, Oga T, Machida K, Chihara Y, Harada Y, Takahashi K, Sumi K, Handa T, Niimi A, Mishima M, Chin K
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Journal Title
Respir Med
Volume: 104:1850-7
Issue: 12
Pages: 1850-1857
DOI
Related Report
Peer Reviewed
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[Journal Article] Noninvasive Ventilation Improves the Outcome of Pulmonary Complications after Liver Resection2010
Author(s)
Narita M, Tanizawa K, Chin K, Ikai I, Handa T, Oga T, Niimi A, Tsuboi T, Mishima M, Uemoto S, Hatano E
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Journal Title
Internal Medicine
Volume: 49
Issue: 15
Pages: 1501-1507
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Importance of the PaCO(2) from 3 to 6 months after initiation of long-term non-invasive ventilation.2010
Author(s)
Tomomasa Tsuboi, Motoharu Ohi, Kazuko Machida, Toru Oga, Yuichi Chihara, Yuka Harada, Kenichi Takahashi, Kensuke Sumi, Tomohiro Handa, Akio Niimi, Michiaki Mishima, Kazuo Chin.
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Journal Title
Respir Med.
Volume: 104(12)
Pages: 1850-1857
NAID
Related Report
Peer Reviewed
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[Journal Article] Noninvasive ventilation improves the outcomes of pulmonary complications after liver resection.2010
Author(s)
Narita M, Tanizawa K, Chin K, Handa T, Oga T, Niimi A, Tsuboi T, Ikai I, Mishima M, Uemoto S, Hatano E.
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Journal Title
Internal Medicine
Volume: 49
Pages: 1501-1507
NAID
Related Report
Peer Reviewed
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[Journal Article] A urine biomarker for severe OSA: Lipocaline-Type prostaglandin D synthase
Author(s)
Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C, Hitomi T, Oga T, Mishima M, Urade Y
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Journal Title
European Respiratory Journal
Volume: (in press)
Related Report
Peer Reviewed
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