| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
This study aims to analyze the roles of mDia known as Rho effectors in refractory pulmonary diseases and to elucidate their pathogenesis and develop novel therapies. In an acute asthma model, mice deficient in mDia1 showed less numbers of total cells and eosinophils and lower concentrations of Th2 cytokines in bronchoalveolar lavage fluid than wild-type mice. Airway hyperresponsiveness in asthmatic mice deficient in mDia1 was also reduced as compared to asthmatic wild-type mice. Thus, mDia1 contributes to allergic airway inflammation and can be a therapeutic target.
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