Role and significance for signaling system of micropaticles in interstitial pneumonia

• Project/Area Number: 22590868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Miyazaki
• Principal Investigator: NAGATOMO Yasuhiro 宮崎大学, 医学部, 講師 (20268600)
• Co-Investigator(Kenkyū-buntansha): OKAYAMA Akihiko 宮崎大学, 医学部, 教授 (70204047)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マイクロパーティクル・情報伝達物質 / 間質性肺炎 / マイクロパーティクル / 情報伝達物質 / サルコイドーシス / 炎症

Research Abstract

Interstitial pneumonia (IP) is a poor-prognosis disease and itscausative agent is still not clear. Micro particle (MP)s are small vesicles derived fromthe activated cells and known to have function like cytokines. In the present study, MPs in the bronchoalveolar lavage fluid (BALF) were measured by FACS to clarify its relationship to the pathogenesis of IP. MPs were found to be measurable in BALF of IP patients. The levels of MPs were positively correlated with total WBC counts, especially counts of lymphocytes, in BALF, not with granulocytes counts in BALF and serum LDH levels. These data suggested that MPs in BALF is not reflected the disease activity of IP and there is a possibility that MPs may have anti-inflammatory effect. Further study is necessary to include more number of patients and methodology to assess the regulatory factors in the pathogenesis of IP.

Research Products

• [Journal Article] Arthropathy with infiltrate IgG4 positive plasma cells in synovium (2012)
  • Author(s): Umekita K, Kaneko Y, Yorita K, Hashiba Y, Matuda M, Miyauchi S, Ueno S, Takajo I, Kusumoto N, Nagatomo Y, Marutsuka K, Okayama A
  • Journal Title: Rheumatology Volume: 51(3) Issue: 3 Pages: 580-582
  • DOI: 10.1093/rheumatology/ker350
  • Peer Reviewed
• [Journal Article] Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept (2011)
  • Author(s): Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
  • Journal Title: Internal Medicine Volume: 50 Issue: 11 Pages: 1245-1249
  • DOI: 10.2169/internalmedicine.50.4879
  • NAID: 130000770480
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Presentation] サルコイドーシスにおけるマイクロパーティクル発現に関する検討 (2013)
  • Author(s): 長友安弘、上野史朗、楠元紀生、川口剛、松田基弘、宮内俊一、高城一郎、梅北邦彦、岡山昭彦
  • Organizer: 第53回日本呼吸器学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2013-04-19
• [Presentation] サルコイドーシスにおけるマイクロパーティクル発現に関する検討 (2013)
  • Author(s): 長友安弘、上野史朗、楠元規生、川口剛、松田基弘、宮内俊一、高城一郎、梅北邦彦、岡山昭彦
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 関節リウマチにおける末梢血血小板由来マイクロパーティクルの臨床的意義 (2011)
  • Author(s): 梅北邦彦, 宮内俊一, 上野史朗, 高城一郎, 楠元規生, 坂口翔太, 金子裕美, 橋場弥生, 松田基弘, 久保和義, 長友安弘, 日高利彦, 岡山昭彦
  • Organizer: 第55回日本リウマチ学会総会・学術集会,第20回国際リウマチシンポジウム
  • Place of Presentation: 神戸ポートピアホテル(神戸市)
  • Year and Date: 2011-07-19
• [Presentation] 関節リウマチ患者におけるCD147陽性単球とマイクロパーティクルの臨床的意義 (2010)
  • Author(s): 梅北邦彦, 宮内俊一, 上野史朗, 橋場弥生, 松田基弘, 久保和義, 高城一郎, 甲斐泰文, 長友安弘, 日高利彦, 岡山昭彦
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-04-23