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INVOLVMENT OF TH17 CELLS IN TUMOR ANGIOGENESIS INDUCED BY INTERACION BETWEEN NON-SMALL CELL LUNG CANCER CELLS AND INTERSTITIAL STROMAL CELLS

Research Project

Project/Area Number 22590869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionJosai University

Principal Investigator

NUMASAKI Muneo  城西大学, 薬学部, 教授 (50344677)

Co-Investigator(Kenkyū-buntansha) HAGIWARA Kouiti  埼玉医科大学, 医学部, 教授 (00240705)
Co-Investigator(Renkei-kenkyūsha) TAGAWA Masatoshi   (20171572)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsサイトカイン / 肺癌 / Th17 細胞 / 血管新生 / 血管新生因子 / Th17
Research Abstract

Th17 cells were isolated and culture supernatants were collected. Culture supernatants of Th17 cells were found to have the activity to induce neovascular formation, and this activity was inhibited, in part, by an anti-IL-17 antibody.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (18 results) Book (2 results) Remarks (1 results)

  • [Journal Article] A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells2012

    • Author(s)
      Fujie H、 Niu K、 Ohba M、Tomioka Y、Kitazawa H、Nagashima K、Ohrui T 、 Numasaki M
    • Journal Title

      Inflammation

      Volume: 35 Issue: 3 Pages: 1119-1131

    • DOI

      10.1007/s10753-011-9419-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Distinct Regulatory Role of Th17 Cytokines IL-17A and IL-17F in Chemokine Secretion from Lung Microvascular Endothelial Cells2012

    • Author(s)
      Fujie H, Niu K, Ohba M, Tomioka Y, Kitazawa H, Nagashima K, Ohrui T, Numasaki M
    • Journal Title

      Inflammation

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenoviruses-mediated transduction of human esophageal carcinoma cells with the interferon-lambda genes produced anti-tumor effects2011

    • Author(s)
      Li, Q., Kawamura, K., Okamoto, S., Fujie, H., Numasaki, M., Namba, M., Nagata, M., Shimada, H., Kobayashi, H. and Tagawa, M.
    • Journal Title

      Br. J. Cancer

      Volume: 105 Issue: 9 Pages: 1302-1312

    • DOI

      10.1038/bjc.2011.379

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor activity of type III interferon alone or in combination with type I interferon against human non-small cell lung cancer2011

    • Author(s)
      Fujie H、 Tanaka T、Tagawa M、 Kaijun N、 Watanabe M、 Suzuki T、 Nakayama K、 Numasaki M
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 11 Pages: 1977-1990

    • DOI

      10.1111/j.1349-7006.2011.02079.x

    • NAID

      120005518441

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system : finding new anti-inflammatory immunobiotics2011

    • Author(s)
      Fujie, H., H.Aso, Y.Suda, T.Saito, H.Kitazawa, et al
    • Journal Title

      FEMS Immunol.Med.Microbiol.

      Volume: 63 Issue: 1 Pages: 129-139

    • DOI

      10.1111/j.1574-695x.2011.00837.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 42011

    • Author(s)
      Ueda, W., H.Aso, Y.Kawai, T.Saito, H.Kitazawa, et al
    • Journal Title

      Vet.Immunol.Immunopathol.

      Volume: 143 Issue: 1-2 Pages: 148-154

    • DOI

      10.1016/j.vetimm.2011.05.026

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-1 genes produced anti-tumour effects2011

    • Author(s)
      Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, Nagata M, Shimada H, Kobayashi H, Tagawa M
    • Journal Title

      British Journal of Cancer

      Volume: 105 Pages: 1302-1312

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor activity of type III interferon alone or in combination with type I interferon against human non-small cell lung cancer2011

    • Author(s)
      Fujie H, Tanaka T, Tagawa M, Kaijun N, Watanabe M, Suzuki T, Nakayama K, Numasaki M
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 1977-1990

    • NAID

      120005518441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system : finding new anti-inflammatory immunobiotics2011

    • Author(s)
      Fujie H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y, Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H
    • Journal Title

      FEMS immunology and medical microbiology

      Volume: 63 Pages: 129-139

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 42011

    • Author(s)
      Ueda W, Tohno M, Shimazu T, Fujie H, Aso H, Kawai Y, Numasaki M, Saito T, Kitazawa H
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: 43 Pages: 148-154

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway.2011

    • Author(s)
      Tomoyuki Shimazu, Julio Villena, Masanori Tohno, Hitomi Fujie, Takeshi Shimosato, Hisashi Aso, Yoshihito Suda, Yasushi Kawai, Tadao Saito, Seiya Makino, Shuji Ikegami, Hiroyuki Itoh, Muneo Numasaki, Haruki Kitazawa
    • Journal Title

      Infection and Immunity

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Distinct Regulatory Role of the Th17 Cytokines IL-17A and IL-17F in Chemokine Secretion from Lung Microvascular Endothelial Cells.2011

    • Author(s)
      Hitomi Fujie, Saori Ishiyama, Masatoshi Tagawa, Niu Kaijun, Haruki Kitazawa, Yoshihisa Tomioka, Muneo Numasaki.
    • Journal Title

      Inflammation

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type III interferon alone or in combination with type I interferon inhibits the growth of human non-small cell lung cancer in vitro and in vivo.2011

    • Author(s)
      Hitomi Fujie, Toshiaki Tanaka, Saori Ishiyama, Masatoshi Tagawa, Katsutoshi Nakayama, Takashi Suzuki, Muneo Numasaki.
    • Journal Title

      Cancer Science

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents2010

    • Author(s)
      Li Q、 Kawamura K、 Ma G、 Iwata F、 Numasaki M、 Suzuki N、 Shimada H、Tagawa M
    • Journal Title

      Eur. J. Cancer

      Volume: 46 Issue: 1 Pages: 180-190

    • DOI

      10.1016/j.ejca.2009.10.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Toll-like receptor-2 activating bifidobacteria strains regulate inflammatory responces in porcine intestinal epithelial cells2011

    • Author(s)
      Fujie H、Villena J、Tohno M、Morie K、Shimazu T、Aso H、Suda Y、Shimosato T、Iwabuchi N、Xiao JZ、Yaeshima T、Iwatsuki K、Numasaki M、Kawai Y、Saito T、Kitazawa H
    • Organizer
      FEMS Congress of European Microbiologists
    • Place of Presentation
      スイス
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th17サイトカインと肺癌、シンポジウム炎症と肺癌-発症、進展における共通のメカニズムを探る-2011

    • Author(s)
      沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17 cytokine family IL-17A、IL-17A/F及びIL-17Fによる気道上皮細胞のケモカイン産生の制御2011

    • Author(s)
      野口愛、沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17は、血管内皮細胞上のフラクタルカインが誘導するNK cellの活性化により腫瘍の肺転移を抑制する2011

    • Author(s)
      成井ももこ、沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Toll-like receptor-2 activating bifidobacteria strains regulate inflammatory responces in porcine intestinal epithelial cells2011

    • Author(s)
      Fujie H、Villena J、Tohno M、Morie K、Shimazu T、Aso H、Suda Y、Shimosato T、Iwabuchi N、Xiao JZ、Yaeshima T、Iwatsuki K、Numasaki M、Kawai Y、Saito T、Kitazawa H
    • Organizer
      4th FEMS Congress of European Microbiologists
    • Place of Presentation
      スイス
    • Related Report
      2012 Final Research Report
  • [Presentation] Th17 サイトカインと肺癌、シンポジウム 炎症と肺癌-発症、進展における共通のメカニズムを探る-2011

    • Author(s)
      沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-17 cytokine family IL-17A、IL-17A/F 及び IL-17F による気道上皮細胞のケモカイン産生の制御2011

    • Author(s)
      野口 愛、 沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-17 は、血管内皮細胞上のフラクタルカインが誘導するNK cell の活性化により腫瘍の肺転移を抑制する2011

    • Author(s)
      成井ももこ、沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] インターフェロンラムダ発現型アデノウイルスによる食道がんに対する抗腫瘍効果2010

    • Author(s)
      田川雅敏, 川村希代子, 岡本慎也, 楊珊, 深町利彦, 小林弘, 藤江瞳, 沼崎宗夫, 島田英昭
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪府大阪市・大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17は血管内皮細胞のフラクタルカインの発現を増強することにより腫瘍の肺転移を抑制する2010

    • Author(s)
      藤江瞳, 田川雅敏, 沼崎宗夫
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪府大阪市・大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda achieve anti-tumor effects in vivo.2010

    • Author(s)
      Msatoshi Tagawa, Quanhai Li, Kiyoko Kawamura, Shinya Okamoto, Shan Yang, Hitomi Fujie, Muneo Numasaki, Hideaki Shimada, Hiroshi Kobayashi
    • Organizer
      第16回日本遺伝子治療学会
    • Place of Presentation
      栃木県宇都宮市・栃木県総合文化センター
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda produced anti-tumor effects to human esophageal carcinoma in vivo.2010

    • Author(s)
      Masatoshi Tagawa, Quanhai Li, Kiyoko Kawamura, Shinya Okamoto, Shan Yang, Hiroshi Kobayashi, Muneo Numasaki, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada.
    • Organizer
      ASGCT 2010 Clinical Trials Training Course and 13th Annual Meeting
    • Place of Presentation
      Mariott Wardman Park Hotel, Washington, DC, USA
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] The additive cytostatic effect of Type I and Type III IFNs against human NSCLC.2010

    • Author(s)
      Hitomi Fujie, Muneo Numasaki, Hidenori Takahashi
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都府京都市・国立京都国際会館
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17 は血管内皮細胞のフラクタルカインの発現を増強することにより腫瘍の肺転移を抑制する2010

    • Author(s)
      藤江瞳、 田川雅敏、 沼崎宗夫
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] インターフェロンラムダ発現型アデノウイルスによる食道がんに対する抗腫瘍効果2010

    • Author(s)
      田川雅敏、川村希代子、岡本慎也、楊珊、深町利彦、小林弘、藤江瞳、沼崎宗夫、島田英昭
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda produced anti-tumor effects to human esophageal carcinoma in vivo2010

    • Author(s)
      Msatoshi Tagawa 、 Quanhai Li 、 Kiyoko Kawamura 、 Shinya Okamoto 、 Shan Yang 、Hiroshi Kobayashi 、Muneo Numasaki 、Yuji Tada、 Kenzo Hiroshima、 and Hideaki Shimada
    • Organizer
      ASGCT 2010 Clinical Trials Training Course and 13th Annual Meeting
    • Place of Presentation
      アメリカ
    • Related Report
      2012 Final Research Report
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda achieve anti-tumor effects in vivo2010

    • Author(s)
      Msatoshi Tagawa 、 Quanhai Li 、 Kiyoko Kawamura、 Shinya Okamoto、 Shan Yang、 Hitomi Fujie 、Muneo Numasaki 、Hideaki Shimada 、and Hiroshi Kobayashi
    • Organizer
      第16回日本遺伝子治療学会
    • Place of Presentation
      栃木
    • Related Report
      2012 Final Research Report
  • [Presentation] The additive cytostatic effect of Type I and Type IIIIFNs against human NSCLC2010

    • Author(s)
      Hitomi Fujie 、 Muneo Numasaki 、 and Hidenori Takahash
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Book] Advancements in Tumor Immunotherapy and Cancer Vaccines2012

    • Author(s)
      Hitomi Fujie, Muneo Numasaki
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Book] Type III Interferons IL-28 and IL-29: Novel Interferon Family Members with Therapeutic Potential in Cancer Therapy. In Advancements in Tumor Immunotherapy and Cancer Vaccines2011

    • Author(s)
      Fujie H 、Numasaki M
    • Publisher
      In Advancements in Tumor Immunotherapy and Cancer Vaccines
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.josai.ac.jp/~facpharm/pharma4/yk/department_of_nutritional_physiology.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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