Screening of fusion genes in non-small cell lung cancer
Project/Area Number |
22590870
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Keio University |
Principal Investigator |
SOEJIMA Kenzo 慶應義塾大学, 医学部, 講師 (30236145)
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Co-Investigator(Kenkyū-buntansha) |
HAMAMOTO Junko 慶應義塾大学, 医学部, 助教 (40570239)
NAOKI Katsuhiko 慶應義塾大学, 医学部, 講師 (40265806)
TERAI Hideki 慶應義塾大学, 医学部, 特任助教 (50445293)
SATO Takashi 慶應義塾大学, 医学部, 助教 (20464836)
KAWAMURA Masafumi 慶應義塾大学, 医学部, 客員教授 (70169770)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 非小細胞肺癌 / 網羅的解析 / pathway signature解析 / fibroblast growth factor-9 / microRNA / exon array / 融合遺伝子 / FGF / 腺癌 / 扁平上皮癌 / Exon array / 染色体転座 / pathway signature / PI3K |
Research Abstract |
We performed profiling of mRNA, microRNA and DNA methylation in surgically resected 100 non-small lung cancer (NSCLC) specimens. We have identified several novel candidate molecules for the treatment of NSCLC. We also found that fibroblast growth factor-9
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2013
Author(s)
Hamamoto J, Soejima K, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Yasuda H, Hayashi Y, Sakamoto M, Takebayashi T, Betsuyaku T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The PCR-Invader method (structure-specific 5' nuclease based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens ; comparison with direct sequencing2011
Author(s)
Naoki K, Soejima K, Okamoto H, Hamamoto J, Hida N, Nakachi I, Yasuda H, Nakayama S, Yoda S, Satomi R, Ikemura S, Terai H, Sato T, Watanabe K
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Journal Title
Int J ClinOncol
Volume: 16
Pages: 335-344
NAID
Related Report
Peer Reviewed
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[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure2013
Author(s)
Terai H, Soejima K, Naoki K, Yasuda H, Satomi R, Nakayama S, Yoda S, Ikemura S, Sato T, Ishioka K, Arai D, Ohgino K, Hamamoto J, Betsuyaku T
Organizer
American Association for Cancer Research
Place of Presentation
ワシントン(アメリカ)
Related Report
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[Presentation] FGF9 overexpression promotes tumorigenic potential of non-small cell lung cancer (NSCLC) cells and is associated with poor prognosis in NSCLC2013
Author(s)
Ishioka K, Soejima K, Yasuda H, Ohgino K, Arai D, Kuroda A, Tani T, Sato T, Terai H, Ikemura S, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
Organizer
American Association for Cancer Research
Place of Presentation
ワシントン(アメリカ)
Related Report
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[Presentation] Analysis of aberrant DNA methylation and expression of corre sponding mRNA in EGFR-TKI-sensitive lung cancer cell line with long-term gefitinib exposure2011
Author(s)
H.Terai, K Soejima, K.Naoki, R.Satomi, S.Nakayama, S.Yoda, S.Ikemura, T.Sato, J.Hamamoto, K.Asano, T.Betsuyaku
Organizer
第70回日本癌学会総会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2011-10-05
Related Report
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[Presentation] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2011
Author(s)
Hamamoto J, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, SatoT, Izumi Y, Kawamura M, Nomori H, Hayashi Y, Sakamoto M, Takebayashi T, Soejima K
Organizer
American Association for Cancer Resereach
Place of Presentation
米国、オーランド
Year and Date
2011-04-06
Related Report
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[Presentation] Expression of fibroblast growth factor-9 is associated with poor prognosis of resected non-small cell lung cancer patients2011
Author(s)
Ohgino K, Soejima K, Arai D, Ishioka K, Terai H, Ikemura S, Sato T, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
Organizer
American Association for Cancer Resereach
Place of Presentation
米国、シカゴ
Year and Date
2011-04-03
Related Report
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